Taylor Mercado

Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers.

PMID: Drug Des Devel Ther. 2019 ;13:1087-1098. Epub 2019 Apr 5. PMID: 31118562 Abstract Title: Lung cancer combination therapy: doxorubicin andβ-elemene co-loaded, pH-sensitive nanostructured lipid carriers. Abstract: Co-delivery of drugs to achieve the synergistic anticancer effect is a promising strategy for lung cancer therapy. The purpose of this research is to develop a doxorubicin (DOX) …

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The results show β-elemene protect the retina of diabetic rats from high glucose damage.

PMID: Int J Ophthalmol. 2019 ;12(11):1693-1698. Epub 2019 Nov 18. PMID: 31741856 Abstract Title: Inhibition ofβ-elemene on the expressions of HIF-lα, VEGF and iNOS in diabetic rats model. Abstract: AIM: To evaluate the effect ofβ-elemene on the expressions of hypoxia-inducible factor (HIF)-lα, vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in a …

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Beta-elemene enhances cisplatin-induced apoptosis in bladder cancer cells.

PMID: Oncol Lett. 2020 Jan ;19(1):291-300. Epub 2019 Nov 14. PMID: 31897141 Abstract Title: β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway. Abstract: Cisplatin-based chemotherapy is the standard regimen for patients with bladder cancer, but its effectiveness is limited by high toxicity and the development of drug resistance.β-elemene (β-ELE), a …

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Beta-elemene suppresses tumor growth of diffuse large B-cell lymphoma.

PMID: Biosci Rep. 2020 Feb 28 ;40(2). PMID: 32010942 Abstract Title: β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway. Abstract: BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is considered the most common aggressive subtype of lymphoma. A number of DLBCL patients fail to achieve a response to currently available …

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Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis.

PMID: Biochem Biophys Res Commun. 2020 Jan 29. Epub 2020 Jan 29. PMID: 32007276 Abstract Title: Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis. Abstract: The antimalarial drug Artemisinin has been reported to possess direct anti-tumor effects on various types of tumor cells. However, its anti-tumor potential has not been fully revealed, and its effects …

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MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells.

PMID: Life Sci. 2020 Feb 1 ;242:117228. Epub 2019 Dec 24. PMID: 31881227 Abstract Title: MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. Abstract: AIMS: Berberine (BBR) is reported to induce apoptosis and inhibit migration of leukemic cells, but the underlying pharmacological mechanisms have not been fully revealed. This …

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This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS.

PMID: J Integr Med. 2020 Jan 16. Epub 2020 Jan 16. PMID: 32005442 Abstract Title: Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Abstract: BACKGROUND: A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain …

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Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats.

PMID: Andrology. 2020 Feb 3. Epub 2020 Feb 3. PMID: 32012485 Abstract Title: Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NFκB pathway. Abstract: BACKGROUND: Diabetes mellitus (DM) induces impairment of male reproductive system and is considered as a key factor that could partially provide an explanation for …

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This study highlighted the benefits of berberine administration as antibiotic adjuvant in E. coli sepsis.

PMID: Nat Prod Res. 2020 Feb 3:1-6. Epub 2020 Feb 3. PMID: 32011175 Abstract Title: Potential application of berberine in the treatment ofsepsis. Abstract: Gram-negative sepsis ranks as the leading cause of death in intensive care units. Despite the development of new antibiotics, mortality from gram-negative sepsis remains high. The present study aims to investigate …

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Berberine exhibited significant antifungal activity in Candida spp.

PMID: Drug Des Devel Ther. 2020 ;14:87-101. Epub 2020 Jan 9. PMID: 32021094 Abstract Title: In vitro Antifungal Effects of Berberine Againstspp. In Planktonic and Biofilm Conditions. Abstract: Purpose: Antifungal resistance associated with the extensive use of antifungals and biofilm formation presents major clinical challenges. Thus, new therapeutic strategies for fungal infections are urgently required. …

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