PMID: Iran J Med Sci. 2020 Jan ;45(1):59-66. PMID: 32038060 Abstract Title: The Hydroalcoholic Extract of Saffron Protects PC12 Cells against Aluminum-Induced Cell Death and Oxidative Stress. Abstract: Background: Aluminum (Al) exposure is among the environmental risk factors that may involve in the pathogenesis of neurodegenerative diseases. Oxidative stress has a critical role in the …
Author Archives: Taylor Mercado
Monoterpenoid Geraniol improves anti-TB drug efficiency by interfering with lipidome and virulence of mycobacteria.
PMID: Infect Disord Drug Targets. 2019 Jun 25. Epub 2019 Jun 25. PMID: 31241021 Abstract Title: Monoterpenoid Geraniol improves anti-TB drug efficiency by interfering with lipidome and virulence of mycobacteria. Abstract: BACKGROUND: Tuberculosis (TB) remains a global infectious disorder for which efficient therapeutics are elusive. Nature is a source of novel pharmacologically active compounds with …
Geraniol nanostructured polymeric mixed micelles showed an enhanced neuro-protective effect compared to geraniol oil.
PMID: Pharmaceutics. 2020 Jan 17 ;12(1). Epub 2020 Jan 17. PMID: 31963479 Abstract Title: Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion. Abstract: Brain damage caused by cerebral ischaemia/reperfusion (I/R) can lead to handicapping. So, the present study aims to evaluate the prophylactic and therapeutic …
Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo.
PMID: Fitoterapia. 2019 Nov ;139:104394. Epub 2019 Oct 25. PMID: 31669719 Abstract Title: Geraniol targets K1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo. Abstract: Naturally occurring monoterpenes are known for their various pharmacological activities including anti-inflammation. K1.3 ion channel is a voltage-gated potassium channel and has been validated as a drug …
The cytotoxic concentration of rosmarinic acid can potentiate the effects of MG132 in hepatocellular carcinoma treatment.
PMID: Hum Exp Toxicol. 2019 Dec 26:960327119896614. Epub 2019 Dec 26. PMID: 31876192 Abstract Title: The cytotoxic concentration of rosmarinic acid increases MG132-induced cytotoxicity, proteasome inhibition, autophagy, cellular stresses, and apoptosis in HepG2 cells. Abstract: Rosmarinic acid (RA) is a natural polyphenolic compound derived from many common herbal plants. Although it is known that RA …
Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway.
PMID: Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31985119 Abstract Title: Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway. Abstract: Cisplatin (DDP) is one of the first-line chemotherapeutic agents for non-small cell lung cancer (NSCLC). However, repeated use of cisplatin in clinical practice often induces …
Rosmarinic acid and blue light combination treatment inhibits head and neck squamous cell carcinoma.
PMID: Anticancer Res. 2020 Feb ;40(2):751-758. PMID: 32014917 Abstract Title: Rosmarinic Acid/ Blue Light Combination Treatment Inhibits Head and Neck Squamous Cell Carcinoma. Abstract: BACKGROUND/AIM: This study investigated a novel combined therapy of rosmarinic acid (RA)/blue light on head and neck squamous cell carcinoma (HNSCC) cell proliferation in vitro.MATERIALS AND METHODS: HNSCC cells were exposed …
Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.
PMID: Life Sci. 2020 Feb 15 ;243:117245. Epub 2020 Jan 8. PMID: 31926253 Abstract Title: Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer. Abstract: AIM: To determine the anti-metastatic potential of combinations of two bioactive carotenoids of saffron, crocin and crocetin, on 4T1 breast cancer and …
Crocin protects cardiomyocytes against lipopolysaccharide-induced inflammation.
PMID: Pharmacol Rep. 2019 Nov ;71(6):1228-1234. Epub 2019 Jul 30. PMID: 32002862 Abstract Title: Crocin protects cardiomyocytes against LPS-Induced inflammation. Abstract: BACKGROUND: Sepsis causes organ dysfunctions via elevation of oxidative stress and inflammation. Lipopolysaccharide (LPS) is the major surface molecule of most gram-negative bacteria and routinely used as a sepsis model in investigation studies. Crocin …
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Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.
PMID: Arch Physiol Biochem. 2020 Feb 4:1-13. Epub 2020 Feb 4. PMID: 32013614 Abstract Title: Metabolic impact of saffron and crocin: an updated systematic and meta-analysis of randomised clinical trials. Abstract: The present systematic and meta-analysis study was designed to show the protective impact of saffron and crocin supplementation on hyperlipidaemia and hyperglycaemia in randomised …
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