PMID: Front Pharmacol. 2020 ;11:49. Epub 2020 Feb 7. PMID: 32116724 Abstract Title: Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. Abstract: Hyperuricemia is characterized by abnormally high level of circulating uric acid in the blood and is associated with increased risk of kidney injury. The …
Author Archives: Taylor Mercado
Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure.
PMID: Life Sci. 2020 May 15 ;249:117476. Epub 2020 Feb 28. PMID: 32119962 Abstract Title: Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. Abstract: Mangiferin is a well-known xanthone extracted from mango leaves (Mangifera indica Linn). Mangiferin is widely distributed in the bark, peel, leaf, seed, stalk, and kernel of mango and …
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Mangiferin attenuates LPS/D-GalN-induced acute liver injury by promoting HO-1 in kupffer cells.
PMID: Front Immunol. 2020 ;11:285. Epub 2020 Feb 25. PMID: 32158448 Abstract Title: Mangiferin Attenuates LPS/D-GalN-Induced Acute Liver Injury by Promoting HO-1 in Kupffer Cells. Abstract: Acute liver injury and its terminal phase, hepatic failure, trigger a series of complications, including hepatic encephalopathy, systematic inflammatory response syndrome, and multiorgan failure, with relatively high morbidity and …
Mangiferin relieves lipopolysaccharide-induced injury by up-regulating miR-181a via targeting PTEN in ATDC5 cells.
PMID: Front Pharmacol. 2020 ;11:137. Epub 2020 Mar 5. PMID: 32210798 Abstract Title: Mangiferin Relieves Lipopolysaccharide-Induced Injury by Up-Regulating miR-181aTargeting PTEN in ATDC5 Cells. Abstract: Background: Mangiferin (MF) was reported to possess anti-inflammatory activity. This investigation tried to probe into the underlying mechanism of MF in osteoarthritis.Methods: ATDC5 cells were pretreated with series concentrations of …
Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.
PMID: Pharmacol Res. 2020 Apr 27 ;157:104845. Epub 2020 Apr 27. PMID: 32353588 Abstract Title: Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate. Abstract: Cardiac injury is followed by fibrosis, characterized by myofibroblast activation. Excessive deposition of extracellular matrix (ECM) impairs the plasticity of myocardium and results in myocardial systolic and diastolic …
Tomatidine may be a promising drug for osteoporosis.
PMID: Med Sci Monit. 2020 Apr 17 ;26:e923996. Epub 2020 Apr 17. PMID: 32300098 Abstract Title: Tomatidine Alleviates Osteoporosis by Downregulation of p53. Abstract: BACKGROUND As a common metabolic disorder, osteoporosis is characterized by decreasing bone mass density and increased possibility of fragility fracture. The incidence of senile osteoporosis increases year by year. There is …
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Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo.
PMID: Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 13. Epub 2020 Mar 13. PMID: 32173393 Abstract Title: Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo. Abstract: OBJECTIVE: The aim of this study was to evaluate the chemopreventive activity of Malaysian jungle Tualang honey (TH) after oral carcinogenesis induced with …
Propolis extract has bioactivity on the wall and cell membrane of Candida albicans.
PMID: J Ethnopharmacol. 2020 Jun 28 ;256:112791. Epub 2020 Mar 28. PMID: 32234352 Abstract Title: Propolis extract has bioactivity on the wall and cell membrane of Candida albicans. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The use of natural products such as propolis extract (PE) is a promising alternative when topically administered to replace conventional antifungals, mostly due to …
Protective effect and mechanism of action of rosmarinic acid on radiation-induced parotid gland injury.
PMID: Dose Response. 2020 Jan-Mar;18(1):1559325820907782. Epub 2020 Feb 20. PMID: 32127788 Abstract Title: Protective Effect and Mechanism of Action of Rosmarinic Acid on Radiation-Induced Parotid Gland Injury in Rats. Abstract: The parotid glands are damaged by oxidative stress and a series of pathophysiological changes after irradiation. Rosmarinic acid (RA) is a natural antioxidant that provides …
Topical application of wogonin provides a novel treatment of knee osteoarthritis.
PMID: Front Physiol. 2020 ;11:80. Epub 2020 Feb 18. PMID: 32132930 Abstract Title: Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis. Abstract: Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant(colloquially known as skullcap), has previously been …
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