PMID: Oncol Rep. 2014 Feb ;31(2):755-62. Epub 2013 Dec 16. PMID: 24337492 Abstract Title: Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. Abstract: Licochalcone A (Lico-A) is a natural phenol licorice compound with multiple bioactivities, including anti-inflammatory, anti-microbial, anti-fungal and osteogenesis-inducing properties. In the present study, we …
Author Archives: Taylor Mercado
Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells.
PMID: PLoS One. 2014 ;9(1):e86537. Epub 2014 Jan 22. PMID: 24466137 Abstract Title: Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-κB mediated urokinase plasminogen activator expression. Abstract: Hepatocellular cell carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide and in Taiwan. Chemoprevention of cancer …
Licochalcone A as a potent antitumor agent suppresses growth of human oral cancer SCC-25 cells in vitro via caspase-3 dependent pathways.
PMID: Tumour Biol. 2014 Jul ;35(7):6549-55. Epub 2014 Apr 2. PMID: 24691971 Abstract Title: Licochalcone A as a potent antitumor agent suppresses growth of human oral cancer SCC-25 cells in vitro via caspase-3 dependent pathways. Abstract: The majority of anticancer drugs are of natural origin. However, it is unknown whether licochalcone A is cytotoxic towards …
Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases.
PMID: Tumour Biol. 2014 Aug ;35(8):7467-74. Epub 2014 May 1. PMID: 24789273 Abstract Title: Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases. Abstract: Licochalcone A, a major phenolic constituent of the licorice species Glycyrrhiza inflata, has been proven to possess various biological benefits including anti-cancer activity. However, the detailed effects and …
Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root.
PMID: Nutr Res Pract. 2014 Jun ;8(3):257-66. Epub 2014 May 15. PMID: 24944769 Abstract Title: Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root. Abstract: BACKGROUND/OBJECTIVE: Licorice has been shown to possess cancer chemopreventive effects. However, glycyrrhizin, a major component in licorice, was found to interfere with steroid metabolism and cause edema …
Licochalcone A inhibits the migration and invasion of human lung cancer cells.
PMID: Tumour Biol. 2014 Dec ;35(12):12139-49. Epub 2014 Aug 23. PMID: 25149157 Abstract Title: Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression. Abstract: Licochalcone A (LicA), a major phenolic constituent of Glycyrrhiza inflata, has been reported to exhibit anti-tumor, …
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Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo.
PMID: Exp Dermatol. 2015 Jan ;24(1):42-7. Epub 2014 Dec 8. PMID: 25381913 Abstract Title: Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo. Abstract: The retrochalcone licochalcone A (LicA) has previously been shown to possess antimicrobial and anti-inflammatory properties. In this study, we focused on pathways responsible …
Licochalcone-A sensitizes human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP.
PMID: Hepatogastroenterology. 2014 Jul-Aug;61(133):1229-34. PMID: 25436288 Abstract Title: Licochalcone-A sensitizes human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP. Abstract: BACKGROUND/AIMS: Esophageal carcinoma is one of the most aggressive human cancers, and novel treatment modality is required. Although expressing adequate levels of functional tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR4/DR5, significant …
These data suggest that licochalcone-A has potential chemopreventive effects.
PMID: Food Chem Toxicol. 2015 Mar ;77:34-43. Epub 2015 Jan 5. PMID: 25572524 Abstract Title: Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells. Abstract: We investigated Licochalcone-A (Lico-A)-induced apoptosis and the pathway underlying its activity in a pharyngeal squamous carcinoma FaDu cell …
Continue reading “These data suggest that licochalcone-A has potential chemopreventive effects.”
Licochalcone A may be a potential bioactive material to control human malignant pleural mesothelioma cells by apoptosis.
PMID: Int J Oncol. 2015 Mar ;46(3):1385-92. Epub 2015 Jan 13. PMID: 25586190 Abstract Title: Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway. Abstract: Licochalcone A (LCA) is a natural product derived from the roots of Glycyrrhiza inflata exhibiting a wide range of bioactivities …
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