Author Archives: Taylor Mercado

PMID:  Sci Rep. 2015 May 18 ;5:10336. Epub 2015 May 18. PMID: 25981581 Abstract Title:  Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Abstract:  Both phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis …

Continue reading “Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis.”

PMID:  Oncotarget. 2015 Oct 6 ;6(30):28851-66. PMID: 26311737 Abstract Title:  Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells. Abstract:  The use of dietary bioactive compounds in chemoprevention can potentially reverse, suppress, or even prevent cancer progression. However, the effects of licochalcone A (LicA) on …

Continue reading “These findings demonstrate the chemotherapeutic potential of licochalcone A for treatment of human cervical cancer.”

PMID:  Inflammation. 2016 Apr ;39(2):569-74. PMID: 26552405 Abstract Title:  Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation. Abstract:  Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), has been reported to have anti-inflammatory activity. However, the protective effects of Lico A on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) remains …

Continue reading “Licochalcone A attenuates lipopolysaccharide-induced acute kidney injury by inhibiting NF-κB activation.”

PMID:  Planta Med. 2019 Nov ;85(16):1203-1215. Epub 2019 Sep 20. PMID: 31539918 Abstract Title:  Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Abstract:  , a triterpene-rich medicinal herb, is traditionally used to treat various types of diseases including neurological, dermatological, and metabolic diseases. A few articles have previously reviewed a broad range …

Continue reading “A review of the cardiovascular protective effects of Centella asiatica and its triterpenes.”

PMID:  Mol Med Rep. 2016 Jul ;14(1):911-9. Epub 2016 May 24. PMID: 27221781 Abstract Title:  Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels. Abstract:  Licochalcone A (LCA) has been reported to significantly inhibit cell proliferation, increase reactive oxygen species (ROS) levels, and induce apoptosis of T24 human bladder cancer cells via …

Continue reading “Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels.”

PMID:  Biomed Pharmacother. 2017 Jan ;85:425-433. Epub 2016 Nov 27. PMID: 27903423 Abstract Title:  Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Abstract:  Chalcones are precursors of flavonoids that exhibit structural heterogeneity and potential antitumor activity. The objective of this study was to characterize …

Continue reading “Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest.”

PMID:  J Ethnopharmacol. 2017 Feb 23 ;198:331-337. Epub 2017 Jan 19. PMID: 28111219 Abstract Title:  Antioxidative and anticancer properties of Licochalcone A from licorice. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Licochalcone A (LCA) is a characteristic chalcone that is found in licorice, which is a traditional medicinal plant. In traditional medicine, LCA possesses many potential biological activities, including …

Continue reading “Antioxidative and anticancer properties of licochalcone A from licorice.”

PMID:  Oncol Lett. 2017 Mar ;13(3):1695-1701. Epub 2017 Jan 18. PMID: 28454311 Abstract Title:  Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells. Abstract:  Licochalcone A (LCA) is a flavonoid extracted from licorice root that has antiparasitic, antibacterial and antitumor properties. Previous studies have revealed that LCA may …

Continue reading “Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells.”

PMID:  J Cell Biochem. 2017 12 ;118(12):4652-4663. Epub 2017 Jun 12. PMID: 28498645 Abstract Title:  Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells. Abstract:  Licochalcone A (LCA), isolated from the root of Glycyrrhiza inflata, are known to have medicinal effect such as anti-oxidant, anti-bacterial, anti-viral, and anti-cancer. Though, …

Continue reading “Licochalcone A suppresses specificity protein 1 as a novel target in human breast cancer cells.”

PMID:  FEBS Open Bio. 2017 06 ;7(6):835-844. Epub 2017 May 8. PMID: 28593138 Abstract Title:  Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction. Abstract:  Glioblastoma multiforme is the most malignant primary intrinsic brain tumor. Glioma stem cells (GSCs) are associated with chemoradiotherapy resistance and the recurrence of glioblastomas after conventional …

Continue reading “Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.”