Taylor Mercado

Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs.

PMID: Environ Sci Pollut Res Int. 2020 Feb 8. Epub 2020 Feb 8. PMID: 32036533 Abstract Title: Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs. Abstract: Due to industrial and urban sewage, the metal contaminations in aquatic and terrestrial environments are increasing day by day, especially …

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Vitamin C and thiamine is associated with increased survival in septic ICU patients.

PMID: J Trauma Acute Care Surg. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32039973 Abstract Title: Vitamin C and Thiamine Are Associated with Lower Mortality in Sepsis. Abstract: INTRODUCTION: The efficacy of vitamin C (VitC) and thiamine (THMN) in patients admitted to the intensive care unit (ICU) with sepsis is unclear. The purpose of …

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Atomic force microscopy technique used for assessment of the anti-arthritic effect of licochalcone A via suppressing NF-κB activation.

PMID: Biomed Pharmacother. 2018 Jul ;103:1592-1601. Epub 2018 May 7. PMID: 29864947 Abstract Title: Atomic force microscopy technique used for assessment of the anti-arthritic effect of licochalcone A via suppressing NF-κB activation. Abstract: Atomic force microscopy (AFM) is appropriately applied to the examination of hard surfaces and soft samples with extremely high resolution and ultrasensitive …

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Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis.

PMID: Phytomedicine. 2020 Jan ;66:153108. Epub 2019 Oct 4. PMID: 31790896 Abstract Title: Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis. Abstract: BACKGROUND: Liquiritigenin (LQ), an aglycone of liquiritin in licorice, has demonstrated antioxidant, anti-inflammatory and anti-tumor activities. Previously, LQ was found to inhibit liver fibrosis progression.PURPOSE: Phosphatase and tensin homolog …

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Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury.

PMID: Biochem Biophys Res Commun. 2018 11 17 ;506(1):161-168. Epub 2018 Oct 16. PMID: 30340829 Abstract Title: Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-κB pathways. Abstract: PURPOSE: Hypertensive renal injury plays important role in the pathogenesis of end-stage nephropathy and the need …

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Isoliquiritigenin attenuates monocrotaline-induced pulmonary hypertension.

PMID: Evid Based Complement Alternat Med. 2019 ;2019:4568198. Epub 2019 May 26. PMID: 31239860 Abstract Title: Isoliquiritigenin Attenuates Monocrotaline-Induced Pulmonary Hypertension via Inhibition of the Inflammatory Response and PASMCs Proliferation. Abstract: Pulmonary hypertension (PH) is a progressive and serious disease, where exacerbated inflammatory response plays a critical role. Isoliquiritigenin (ISL), an important flavonoid isolated from …

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Isoliquiritigenin could be a promising agent for preventing hepatocellular carcinoma tumorigenesis and metastasis.

PMID: Biosci Rep. 2020 01 31 ;40(1). PMID: 31840737 Abstract Title: Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway. Abstract: The overall survival rate of patients with hepatocellular carcinoma (HCC) has remained unchanged over the last several decades. Therefore, novel drugs and therapies are required for …

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A review of the anti-inflammatory, anticancer, antibacterial properties of four kinds of licorice flavonoids isolated from licorice.

PMID: Curr Med Chem. 2018 Sep 30. Epub 2018 Sep 30. PMID: 30277142 Abstract Title: A Review: The Anti-inflammatory, Anticancer, Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice. Abstract: Plants have always been an important source of medicines for humans, and licorice is a very significant herb in the development of humans. …

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Lico A causes ER stress and apoptosis via up-regulating miR-144-3p in human lung cancer cell line H292.

PMID: Front Pharmacol. 2018 ;9:837. Epub 2018 Jul 31. PMID: 30108506 Abstract Title: Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292. Abstract: During our study on the bioactivities of natural flavonoids, we found that the total flavonoids (TFs) and the main constituent of it, licochalcone A …

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Licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential.

PMID: Molecules. 2018 Aug 13 ;23(8). Epub 2018 Aug 13. PMID: 30104527 Abstract Title: Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines. Abstract: In the present investigation,-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We …

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