PMID: Environ Toxicol. 2018 Dec ;33(12):1237-1244. Epub 2018 Sep 6. PMID: 30187994 Abstract Title: Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Abstract: To improve the clinical outcome of tumor chemotherapy, more effective combination treatments against tumor metastasis and recurrence …
Author Archives: Taylor Mercado
Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice.
PMID: Mol Cell Neurosci. 2018 12 ;93:1-9. Epub 2018 Sep 22. PMID: 30253196 Abstract Title: Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function inβ-amyloid overexpressing mice. Abstract: Centella asiatica is a medicinal plant used to enhance memory. We have previously shown that a water extract of Centella asiatica (CAW) attenuatesβ-amyloid (Aβ)-induced …
These results provide new insight into the anti-fibrotic mechanism of asiatic acid.
PMID: Acta Pharmacol Sin. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31705123 Abstract Title: Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Abstract: Renal fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Recently, asiatic acid (AA), a …
Asiatic acid may be an effective plant-based cancer chemotherapeutic agent.
PMID: Anticancer Agents Med Chem. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823705 Abstract Title: Anti-Cancer Effects of Asiatic Acid, A Triterpene From Centilla Asiatica L: A Literature Review. Abstract: BACKGROUND: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a …
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Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing.
PMID: BMC Complement Altern Med. 2019 Aug 14 ;19(1):213. Epub 2019 Aug 14. PMID: 31412845 Abstract Title: Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits. Abstract: BACKGROUND: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in …
Centella asiatica extract attenuates inflammation and improve insulin sensitivity.
PMID: Drug Discov Ther. 2019 ;13(5):261-267. PMID: 31723097 Abstract Title: Centella asiatica (L.) extract attenuates inflammation and improve insulin sensitivity in a coculture of lipopolysaccharide (LPS)-induced 3T3-L1 adipocytes and RAW 264.7 macrophages. Abstract: Insulin resistance in obese condition is related to chronic low-grade inflammation which leads to insulin signaling impairment. Centella asiatica (L.) is an …
Centella Asiatica improves memory and promotes antioxidative signalling in 5XFAD mice.
PMID: Antioxidants (Basel). 2019 Dec 8 ;8(12). Epub 2019 Dec 8. PMID: 31817977 Abstract Title: Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice. Abstract: (CA) herb is a traditional medicine, long reputed to provide cognitive benefits. We have reported that CA water extract (CAW) treatment improves cognitive function of aged Alzheimer's disease (AD) model …
Asiatic acid-induced apoptosis in human cisplatin-resistant nasopharyngeal carcinoma.
PMID: Biomolecules. 2020 Jan 25 ;10(2). Epub 2020 Jan 25. PMID: 31991751 Abstract Title: Asiatic Acid, Extracted fromand Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells. Abstract: Nasopharyngeal carcinoma (NPC) is an important issue in Asia because of its unique geographical and ethnic distribution. Cisplatin-based regimens are commonly …
Gotu kola ethanol extract up-regulates hippocampal brain-derived neurotrophic factor which could be useful in memory disorders.
PMID: Iran J Basic Med Sci. 2019 Oct ;22(10):1218-1224. PMID: 31998466 Abstract Title: (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Abstract: Objectives: Impairment of hippocampus function as a center for memory processing occurs …
C. asiatica L. can affect brain functions by increasing Bdnf expression and by enhancing the cognitive performance.
PMID: Nutrients. 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013132 Abstract Title: L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Abstract: A wide range of people in the world use natural remedies as primary approaches against illnesses. Accordingly, understanding the mechanisms of action of phytochemicals has become of …
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