Author Archives: Taylor Mercado

PMID:  Biomed Pharmacother. 2019 Jan ;109:1120-1125. Epub 2018 Nov 6. PMID: 30551362 Abstract Title:  Chrysin attenuates inflammatory and metabolic disorder indices in aged male rat. Abstract:  Advanced age is a major risk factor for metabolic disorders. Accelerated inflammatory processes with increased age can contribute to the pathogenesis of metabolic disturbances. Chrysin is a natural flavonoid …

Continue reading “Chrysin attenuates inflammatory and metabolic disorder indices in aged male rat.”

PMID:  Biomed Pharmacother. 2019 Jan ;109:2387-2395. Epub 2018 Nov 30. PMID: 30551498 Abstract Title:  Chrysin (5,7-dihydroxyflavone) exerts anxiolytic-like effects through GABAreceptors in a surgical menopause model in rats. Abstract:  The present study investigated the effects of the flavonoid chrysin (5,7-dihydroxyflavone) on anxiety-like behavior in rats in a model of surgical menopause and evaluated the participation …

Continue reading “Chrysin exerts anxiolytic-like effects through GABAA receptors in a surgical menopause model.”

PMID:  Environ Toxicol. 2019 Apr ;34(4):434-442. Epub 2018 Dec 22. PMID: 30578657 Abstract Title:  Chrysin inhibit human melanoma A375.S2 cell migration and invasion via affecting MAPK signaling and NF-κB signaling pathway in vitro. Abstract:  Numerous evidences have shown that chrysin induced cytotoxic effects via induced cell cycle arrest and induction of cell apoptosis in human …

Continue reading “Chrysin inhibit human melanoma A375.S2 cell migration and invasion.”

PMID:  Anticancer Res. 2019 Feb ;39(2):695-701. PMID: 30711947 Abstract Title:  Chrysin-induced ERK1/2 Phosphorylation Enhances the Sensitivity of Human Hepatocellular Carcinoma Cells to Sorafenib. Abstract:  BACKGROUND/AIM: Sorafenib is now standard treatment for advanced hepatocellular carcinoma (HCC). However, therapeutic efficacy is not as good as was predicted. Many efforts are being made to improve HCC sensitivity to …

Continue reading “Chrysin-induced ERK1/2 phosphorylation enhances the sensitivity of human hepatocellular carcinoma cells to sorafenib.”

PMID:  Brain Behav Immun. 2019 07 ;79:228-235. Epub 2019 Feb 7. PMID: 30738841 Abstract Title:  A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway. Abstract:  Neuroinflammation is now recognized to be a feature of many neurological disorders. More accumulated evidences suggested chrysin which was contained in honey, …

Continue reading “A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway.”

PMID:  Drug Chem Toxicol. 2020 Feb 3:1-7. Epub 2020 Feb 3. PMID: 32013615 Abstract Title:  Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. Abstract:  Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) …

Continue reading “A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.”

PMID:  Chem Biol Interact. 2019 Apr 1 ;302:123-134. Epub 2019 Feb 19. PMID: 30794797 Abstract Title:  Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes. Abstract:  Paracetamol (N-acetyl-para amino phenol) is the most commonly used analgesic and antipyretic around the world. Its causes hepatotoxicity and …

Continue reading “Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol.”

PMID:  Biomed Pharmacother. 2019 Apr ;112:108619. Epub 2019 Feb 20. PMID: 30797156 Abstract Title:  Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis. Abstract:  Global cerebral ischemia is a leading cause of mortality worldwide. Several biomechanisms play a role in the pathology of cerebral ischemia reperfusion damage, such as …

Continue reading “Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis.”

PMID:  J Biochem Mol Toxicol. 2019 Feb 22:e22313. Epub 2019 Feb 22. PMID: 30801880 Abstract Title:  The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. Abstract:  Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is …

Continue reading “These results showed that CH exhibited an ameliorative effect against cyclophosphamide-induced brain, heart, liver, testis, and kidney toxicity.”

PMID:  Exp Ther Med. 2019 Mar ;17(3):2256-2262. Epub 2019 Jan 21. PMID: 30867710 Abstract Title:  Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Abstract:  Renal ischemia reperfusion (IR) is a major cause of acute kidney injury with no effective treatment. Chrysin is an anti-inflammatory, anti-oxidant and anti-cancer agent. However, …

Continue reading “Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation.”