Taylor Mercado

P-coumaric acid may be a promising candidate for the treatment of osteoarthritis.

PMID: Inflammation. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823179 Abstract Title: p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes. Abstract: Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by cartilage degradation. p-Coumaric acid (PCA), a dietary phenolic compound, has exerted anti-inflammatory and anti-oxidative activities in various diseases. …

Continue reading “P-coumaric acid may be a promising candidate for the treatment of osteoarthritis.”

Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion.

PMID: Nefrologia. 2019 Dec 28. Epub 2019 Dec 28. PMID: 31892486 Abstract Title: Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion. Abstract: BACKGROUND AND AIMS: Renal ischemia-reperfusion occurs in some clinical conditions such as kidney surgery that can leads to acute renal failure. The aim …

Continue reading “Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion.”

Ferulic acid exhibited protective effects against osteoporosis.

PMID: Biomed Pharmacother. 2019 Dec ;120:109205. Epub 2019 Oct 18. PMID: 31634777 Abstract Title: Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-κB in neonatal rats with glucocorticoid-induced osteoporosis. Abstract: Osteoporosis is a chronic disease whose symptoms include a reduction in bone strength, osteopenia, and damage to the bone microstructure. Ferulic …

Continue reading “Ferulic acid exhibited protective effects against osteoporosis.”

These findings provide a basis for the understanding of the antidiabetic potential of ferulic acid and resveratrol combination.

PMID: Phytother Res. 2019 Dec 4. Epub 2019 Dec 4. PMID: 31802562 Abstract Title: Amelioration of insulin resistance using the additive effect of ferulic acid and resveratrol on vesicle trafficking for skeletal muscle glucose metabolism. Abstract: Dysregulation of vesicle trafficking in muscle is one of the factors responsible for the pathogenesis of insulin resistance (IR). …

Continue reading “These findings provide a basis for the understanding of the antidiabetic potential of ferulic acid and resveratrol combination.”

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity.

PMID: Sci Rep. 2020 Jan 23 ;10(1):1063. Epub 2020 Jan 23. PMID: 31974389 Abstract Title: The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity. Abstract: Platinum-based agents, such as cisplatin, form the mainstay of currently used chemotherapeutic regimens for several malignancies; however, the main limitations are chemoresistance and ototoxic side …

Continue reading “The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity.”

Ferulic acid induces apoptosis of cervical carcinoma cells.

PMID: Med Sci Monit. 2020 Jan 27 ;26:e920095. Epub 2020 Jan 27. PMID: 31983729 Abstract Title: Ferulic Acid Induces Apoptosis of HeLa and Caski Cervical Carcinoma Cells by Down-Regulating the Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling Pathway. Abstract: BACKGROUND Ferulic acid is an antioxidant phenolic compound derived from plants, which has effects on cancer cells. This study …

Continue reading “Ferulic acid induces apoptosis of cervical carcinoma cells.”

The present study suggested that chrysin may be useful for the management of depressant-like effects induced by chronic stress.

PMID: Cardiovasc Hematol Disord Drug Targets. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31237217 Abstract Title: The effects of chrysin on serum corticosterone levels and brain oxidative injury induced by immobilization in rat. Abstract: The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like …

Continue reading “The present study suggested that chrysin may be useful for the management of depressant-like effects induced by chronic stress.”

Chrysin might be a potential therapeutic agent for cerebral ischemia.

PMID: Neurochem Int. 2019 10 ;129:104496. Epub 2019 Jun 25. PMID: 31247243 Abstract Title: Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway. Abstract: In this study, the effects of chrysin on cerebral ischemia by establishing middle cerebral artery occlusion (MCAO) in rat were investigated. In vivo experiments, the rats were …

Continue reading “Chrysin might be a potential therapeutic agent for cerebral ischemia.”

Effects of chrysin on the apoptosis in oral squamous carcinoma KB cell line and the underlying mechanisms.

PMID: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 May 28 ;44(5):522-527. PMID: 31303615 Abstract Title: [Effects of chrysin on the apoptosis in oral squamous carcinoma KB cell line and the underlying mechanisms]. Abstract: To investigate the effect of chrysin on apoptosis of oral squamous carcinoma KB cell line and the possible mechanisms, …

Continue reading “Effects of chrysin on the apoptosis in oral squamous carcinoma KB cell line and the underlying mechanisms.”

Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats.

PMID: Food Funct. 2019 Aug 1 ;10(8):4566-4576. Epub 2019 Jul 17. PMID: 31314039 Abstract Title: Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats. Abstract: Intake of fructose-containing sugars is epidemiological and experimentally linked to metabolic syndrome (MS). We recently verified that the dietary polyphenol chrysin was able to …

Continue reading “Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats.”