PMID: Neurosci Lett. 2019 Sep 14 ;709:134382. Epub 2019 Jul 17. PMID: 31325581 Abstract Title: Chrysin restores MPTP induced neuroinflammation, oxidative stress and neurotrophic factors in an acute Parkinson's disease mouse model. Abstract: Parkinson disease occurs due to the depletion of dopaminergic neurons in brain resulting in decreased dopamine level and abnormal protein aggregation. Chrysin …
Author Archives: Taylor Mercado
Chrysin ameliorates nonalcoholic fatty liver disease in rats.
PMID: Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec ;392(12):1617-1628. Epub 2019 Aug 1. PMID: 31372694 Abstract Title: Chrysin ameliorates nonalcoholic fatty liver disease in rats. Abstract: Nonalcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of the metabolic syndrome. It begins with the accumulation of fat in the liver (simple steatosis), which if untreated …
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The results indicate the possibility of applying ethanol extracts from Polish propolis to protect food against microbiological spoilage.
PMID: Molecules. 2019 Aug 15 ;24(16). Epub 2019 Aug 15. PMID: 31443325 Abstract Title: Growth Biocontrol of Foodborne Pathogens and Spoilage Microorganisms of Food by Polish Propolis Extracts. Abstract: Propolis is a natural mixture produced by bees from plant resin substances. This study focuses on the general characteristics of five samples of Polish extract propolis …
European propolis is highly active against trypanosomatids including Crithidia fasciculata.
PMID: Sci Rep. 2019 Aug 6 ;9(1):11364. Epub 2019 Aug 6. PMID: 31388043 Abstract Title: European propolis is highly active against trypanosomatids including Crithidia fasciculata. Abstract: Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana. The extracts were …
Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice.
PMID: J Neuroimmunol. 2019 Oct 15 ;335:577007. Epub 2019 Jul 16. PMID: 31376787 Abstract Title: Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice. Abstract: We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 …
Chrysin possesses strong antihypertensive and antioxidant properties in L-NAME induced hypertensive rats.
PMID: Indian J Clin Biochem. 2019 Jul ;34(3):288-295. Epub 2018 Jun 14. PMID: 31391718 Abstract Title: Chrysin Pretreatment Improves Angiotensin System, cGMP Concentration in L-NAME Induced Hypertensive Rats. Abstract: N-nitro-l-arginine methyl ester (L-NAME) is a non-specific nitric oxide (NO) synthase inhibitor, commonly used for the induction of NO-deficient hypertension. The objective of the present study …
chrysin may be useful as an adjuvant chemotherapy in lung squamous cell carcinoma.
PMID: Sci Rep. 2019 Sep 24 ;9(1):13753. Epub 2019 Sep 24. PMID: 31551535 Abstract Title: Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Abstract: The aberrant expression of claudins (CLDNs), which are tight junctional proteins, is seen in …
Chrysin has a protective effect against cyclophosphamide -induced hepatorenal toxicity.
PMID: Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31620822 Abstract Title: Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Abstract: Cyclophosphamide (CYP) is a chemotherapeutic agent used in the treatment of autoimmune disorders and malignant diseases. However, its usage is …
Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.
PMID: Chem Res Toxicol. 2019 Nov 18 ;32(11):2329-2337. Epub 2019 Nov 1. PMID: 31625388 Abstract Title: Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat. Abstract: Acetaminophen is a commonly used analgesic drug that induces hepatotoxicity at high doses and produces the acetaminophen metabolite-acetyl–benzoquinone imine (NAPQI) through oxidase isoenzyme system. The antioxidant and anti-inflammatory activity …
Chrysin and docetaxel loaded biodegradable micelle for combination chemotherapy of cancer stem cell.
PMID: Pharm Res. 2019 Oct 23 ;36(12):165. Epub 2019 Oct 23. PMID: 31646391 Abstract Title: Chrysin and Docetaxel Loaded Biodegradable Micelle for Combination Chemotherapy of Cancer Stem Cell. Abstract: PURPOSE: Cancer stem cells (CSCs) have been suggested to represent the main cause of tumour progression, metastasis and drug resistance. Therefore, these cells can be an …
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