PMID: Korean J Physiol Pharmacol. 2018 Sep ;22(5):525-538. Epub 2018 Aug 27. PMID: 30181699 Abstract Title: Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder. Abstract: Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the …
Author Archives: Taylor Mercado
These results suggest ligustrazine has therapeutic potential for arthritis.
PMID: Arch Pharm Res. 2019 Sep ;42(9):824-831. Epub 2018 Nov 17. PMID: 30448958 Abstract Title: Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways. Abstract: Inflammation responses and oxidative stress are closely involved in the pathogenesis of arthritis. Ligustrazine (Lig), a natural four methyl which is …
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Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet
PMID: Mol Med Rep. 2019 Apr ;19(4):2561-2568. Epub 2019 Feb 1. PMID: 30720104 Abstract Title: Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. Abstract: The present study aimed to assess the protective effects of tetramethylpyrazine (TMP) on the livers of mice fed a high fat diet. The mice were divided into …
Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes.
PMID: J Cell Physiol. 2019 Feb 15. Epub 2019 Feb 15. PMID: 30770559 Abstract Title: Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a. Abstract: Inadequate oxygen supply is probably one of the most important pathophysiological mechanisms of cardiomyocyte damage in ischemic heart disease. Tetramethylpyrazine (TMP, also known as ligustrazine) is the …
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Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway.
PMID: Psychopharmacology (Berl). 2019 Jul ;236(7):2173-2185. Epub 2019 Mar 7. PMID: 30847567 Abstract Title: Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice. Abstract: Depression is a common but serious mental illness; meanwhile, it is also an inflammatory disorder. Toll-like receptor 4 (TLR4), as the pattern recognition receptor, has been shown to play …
Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia.
PMID: Cell Mol Biol Lett. 2019 ;24:17. Epub 2019 Feb 26. PMID: 30858867 Abstract Title: Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway. Abstract: Objective: We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO).Materials and …
Tetramethylpyrazine nitrone reduces oxidative stress to alleviate cerebral vasospasm in experimental subarachnoid hemorrhage models.
PMID: Neuromolecular Med. 2019 Sep ;21(3):262-274. Epub 2019 May 27. PMID: 31134485 Abstract Title: Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models. Abstract: Cerebral vasospasm is one of the deleterious complications after subarachnoid hemorrhage (SAH), leading to delayed cerebral ischemia and permanent neurological deficits or even death. Free radicals …
Tetramethylpyrazine attenuates the endotheliotoxicity and the mitochondrial dysfunction by doxorubicin.
PMID: Oxid Med Cell Longev. 2019 ;2019:5820415. Epub 2019 Dec 3. PMID: 31885804 Abstract Title: Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin14-3-3/Bcl-2. Abstract: Doxorubicin (Dox) with cardiotoxicity and endotheliotoxicity limits its clinical application for cancer. The toxicitic mechanism involves excess ROS generation. 14-3-3s have the protective effects on various injured tissues and …
Tetramethylpyrazine is a promising treatment of pulmonary hypertension.
PMID: Br J Pharmacol. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31976548 Abstract Title: Tetramethylpyrazine, a Promising Drug for Treatment of Pulmonary Hypertension. Abstract: RATIONALE: Tetramethylpyrazine (TMP) is a compound isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto. TMP can also be chemosynthesized in pharmacy and has long history …
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Tetramethylpyrazine reverses high-glucose induced hypoxic effects.
PMID: Nutr Metab (Lond). 2020 ;17:12. Epub 2020 Jan 31. PMID: 32021640 Abstract Title: Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis. Abstract: Background: Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our …
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