Taylor Mercado

Lupeol inhibits migration and invasion of colorectal cancer cells.

PMID: Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 6. Epub 2020 Feb 6. PMID: 32025757 Abstract Title: Lupeol inhibits migration and invasion of colorectal cancer cells by suppressing RhoA-ROCK1 signaling pathway. Abstract: Metastasis is the main cause of death in colorectal cancer (CRC) patients. However, current treatment options for CRC metastasis are very limited. Lupeol, a …

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Ligustrazine prevents intervertebral disc degeneration.

PMID: Biomed Res Int. 2019 ;2019:5601734. Epub 2019 Dec 2. PMID: 31886227 Abstract Title: Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFActivation in Nucleus Pulposus Cells. Abstract: Objectives: Aberrant transforming growth factor(TGF) activation is detrimental to both nucleus pulposus (NP) cells and cartilage endplates (CEPs), which can lead to intervertebral disc degeneration (IDD). …

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Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.

PMID: Int J Mol Med. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31985025 Abstract Title: Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation. Abstract: Ligustrazine has been used to alleviate clinical acute kidney injury (AKI); however, the underlying molecular mechanisms are poorly understood. In order to further elucidate the molecular mechanism underlying …

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U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis.

PMID: Acta Cir Bras. 2019 Mar 18 ;34(3):e201900305. Epub 2019 Mar 18. PMID: 30892391 Abstract Title: Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats1. Abstract: PURPOSE: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).METHODS: …

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Endolichenic fungus, Aspergillus quandricinctus of Usnea longissima inhibits quorum sensing and biofilm formation of Pseudomonas aeruginosa PAO1.

PMID: Microb Pathog. 2019 Dec 17 ;140:103933. Epub 2019 Dec 17. PMID: 31862392 Abstract Title: Endolichenic fungus, Aspergillus quandricinctus of Usnea longissima inhibits quorum sensing and biofilm formation of Pseudomonas aeruginosa PAO1. Abstract: Lichens are composite organisms, comprising of a fungus (mycobiont) and a blue-green alga (photobiont). Along with the mycobiont, numerous non-obligate microfungi live …

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Inhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach.

PMID: An Acad Bras Cienc. 2019 ;91(3):e20180994. Epub 2019 Oct 7. PMID: 31596391 Abstract Title: Inhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach. Abstract: Herbal medicines are efficient to reduce side effects in the fight against glioblastoma, which plays a critical role within brain cancer species. The recent studies designated for …

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Lichen secondary metabolite physciosporin decreases the stemness potential of colorectal cancer cells.

PMID: Biomolecules. 2019 Nov 28 ;9(12). Epub 2019 Nov 28. PMID: 31795147 Abstract Title: Lichen Secondary Metabolite Physciosporin Decreases the Stemness Potential of Colorectal Cancer Cells. Abstract: Secondary metabolites of lichens are promising bioresources for candidate anti-cancer drugs. Accordingly, several approaches have been proposed for screening these molecules for novel anti-cancer lead compounds. In this …

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Anticancer potential of lichens’ secondary metabolites.

PMID: Biomolecules. 2020 Jan 5 ;10(1). Epub 2020 Jan 5. PMID: 31948092 Abstract Title: Anticancer Potential of Lichens' Secondary Metabolites. Abstract: Lichens produce different classes of phenolic compounds, including anthraquinones, xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed effective biological activities such as antioxidant, antiviral, antibiotics, antifungal, and anticancer. Although no clinical study …

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Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.

PMID: J Exp Clin Cancer Res. 2018 Oct 29 ;37(1):260. Epub 2018 Oct 29. PMID: 30373628 Abstract Title: Lentinan inhibits tumor angiogenesis via interferonγ and in a T cell independent manner. Abstract: BACKGROUND: Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy.METHODS: Lentinan (LNT) …

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Lentinan-based chemo-immunotherapy is a promising strategy for anti-tumor via enhancing the proliferation of cytotoxic T cells.

PMID: Pathol Oncol Res. 2018 Nov 20. Epub 2018 Nov 20. PMID: 30460541 Abstract Title: Immunomodulatory Effect of Lentinan on Aberrant T Subsets and Cytokines Profile in Non-small Cell Lung Cancer Patients. Abstract: As a purified active component from traditional Chinese medicine, lentinan administration can be applied as beneficial chemo-immunotherapy for anti-tumor. In this study, …

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