PMID: J Cell Mol Med. 2019 02 ;23(2):750-760. Epub 2018 Nov 24. PMID: 30472806 Abstract Title: Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer. Abstract: In this study, we investigated the therapeutic potential of lentinan in mouse models of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Lentinan decreased the disease activity …
Author Archives: Taylor Mercado
Lentinan administration relieves gut barrier dysfunction induced by rotavirus.
PMID: Food Funct. 2019 Apr 17 ;10(4):2094-2101. PMID: 30916667 Abstract Title: Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model. Abstract: Rotavirus (RV) is a pathogen that induces severe diarrhea in infants and young animals. Shiitake mushroom is a traditional food, which can improve physiological function, including gut health. Lentinan …
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Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China.
PMID: Prog Mol Biol Transl Sci. 2019 ;163:297-328. Epub 2019 Apr 4. PMID: 31030752 Abstract Title: Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Abstract: Lentinula edodes has been used to improve general health for thousands of years in Asia. It is the second largest …
Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes.
PMID: J Cosmet Dermatol. 2020 Feb ;19(2):502-507. Epub 2019 May 28. PMID: 31135098 Abstract Title: Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. Abstract: BACKGROUND: Benzo(a)pyrene, a major environmental pollutant, is known to accelerate skin aging through oxidative stress, increase the production of inflammatory mediators, and cause skin cancer. …
Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1.
PMID: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3938-3946. PMID: 31581847 Abstract Title: Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1. Abstract: Myocardial ischemia is a serious disease which threatens human's life. Lentinan (LEN) possesses multiple biological properties: anticancer, antibacterial, antiviral and antioxidant effects. Our study investigated the effects of LEN on hypoxia-stimulated cardiomyocytes …
Effects of Eriobotrya japonica water extract on alcoholic and nonalcoholic fatty liver impairment.
PMID: J Med Food. 2019 Dec ;22(12):1262-1270. PMID: 31834842 Abstract Title: Effects ofWater Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. Abstract: The aim of this study was to investigate the potential protective effects of the hot water extract of(EJW) on EtOH- or free fatty acid (FFA)-induced fatty liver injury. HepG2/2E1 cells were exposed to …
Dietary lactoferrin supplementation prevents memory impairment and reduces amyloid-β generation.
PMID: J Alzheimers Dis. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31985470 Abstract Title: Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in J20 Mice. Abstract: Lactoferrin (LF) is present in senile plaques and neurofibrillary tangles in the brains of Alzheimer's disease (AD) patients and amyloid-β protein precursor transgenic (AβPP-Tg) mice. LF …
Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells.
PMID: Biol Open. 2017 Oct 15 ;6(10):1416-1422. Epub 2017 Oct 15. PMID: 28838965 Abstract Title: Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress. Abstract: Bufalin has been used to treat cancer for several years. However, the molecular mechanisms for its anti-tumor function are not fully understood. …
Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma.
PMID: Oncotarget. 2017 Sep 8 ;8(38):63311-63323. Epub 2017 Jun 28. PMID: 28968991 Abstract Title: Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma: preparation, characterization, pharmacokinetics and tissue distribution. Abstract: OBJECTIVE: To prepare and evaluate the liver-targeted drug delivery system of Bufalin with higher liver uptake and stronger antitumor activity against hepatocellular …
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase
PMID: Sci Rep. 2018 03 1 ;8(1):3891. Epub 2018 Mar 1. PMID: 29497076 Abstract Title: Bufalin suppresses hepatocarcinogenesis by targetingβ-catenin/TCF signaling via cell cycle-related kinase. Abstract: Hepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors, of which treatment options are limited especially in advanced stage. Bufalin, the major digoxin-like component of the traditional …
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