PMID: Oncol Res. 2019 Mar 29 ;27(4):475-486. Epub 2018 May 24. PMID: 29793559 Abstract Title: Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide. Abstract: Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. …
Author Archives: Taylor Mercado
Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells .
PMID: Oncol Lett. 2018 Jun ;15(6):9339-9346. Epub 2018 Apr 18. PMID: 29805658 Abstract Title: Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway. Abstract: The present study examined whether bufalin could induce human esophageal carcinoma ECA109 cells apoptosis via inhibiting the activation of mechanistic target of rapamycin …
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Bufalin inhibits gastric cancer invasion and metastasis.
PMID: Oncotarget. 2018 May 4 ;9(34):23320-23333. Epub 2018 Jan 11. PMID: 29805736 Abstract Title: Bufalin inhibits gastric cancer invasion and metastasis by down-regulating Wnt/ASCL2 expression. Abstract: Achaete-scute-like 2 (ASCL2) is a transcription factor containing a basic helix-loop-helix (bHLH) domain and is a downstream target of Wnt signaling in intestinal stem cells. Bufalin is the primary …
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Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.
PMID: Oncol Lett. 2018 May ;15(5):8019-8026. Epub 2018 Mar 23. PMID: 29849804 Abstract Title: Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells. Abstract: 5-fluorouracil (5-FU) has been used in the treatment of colorectal cancer for>50 years. However, drug resistance remains an obstacle in the application of 5-FU-based chemotherapy. Bufalin, a type of steroid …
Bufalin inhibits glycolysis-induced cell growth and proliferation in ovarian cancer.
PMID: Am J Cancer Res. 2018 ;8(7):1288-1296. Epub 2018 Jul 1. PMID: 30094101 Abstract Title: Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrinβ2/FAK signaling pathway in ovarian cancer. Abstract: Bufalin is the major digoxin-like component of the traditional Chinese medicine Chansu and has obvious anti-tumor effect in major malignancies, but the …
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells.
PMID: Biochem Biophys Res Commun. 2018 09 10 ;503(3):2124-2131. Epub 2018 Aug 6. PMID: 30100060 Abstract Title: Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway. Abstract: OBJECTIVE: This study aimed to evaluate functions of APOBEC3F gene in biological process of hepatocellular carcinoma …
The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann–Pick C1-Like 1
PMID: Int J Mol Sci. 2019 Oct 6 ;20(19). Epub 2019 Oct 6. PMID: 31590417 Abstract Title: The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann-Pick C1-Like 1. Abstract: The Niemann-Pick C1-like 1 (NPC1L1) protein is a cholesterol transporter that is expressed in the small intestine. This report describes the …
Luteolin could be a promising candidate molecule for atherosclerosis.
PMID: Drug Des Devel Ther. 2019 ;13:3899-3911. Epub 2019 Nov 18. PMID: 31819365 Abstract Title: Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response. Abstract: Background: Inflammatory factors play a crucial role throughout the development and progression of atherosclerosis, which has been considered as a chronic vascular inflammatory disease. Luteolin, …
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Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitis
PMID: Mol Brain. 2019 Dec 26 ;12(1):114. Epub 2019 Dec 26. PMID: 31878979 Abstract Title: Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitis. Abstract: Anxiety related disorders commonly occur in association with major depressive disorder (MDD) in individuals suffering from peripheral inflammation, with a higher prevalence among IBS patients. We …
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Bufalin induced apoptosis of bladder carcinoma cells through the inactivation of Na+K+-ATPase
PMID: Oncol Lett. 2018 Sep ;16(3):3826-3832. Epub 2018 Jul 12. PMID: 30127995 Abstract Title: Bufalin induced apoptosis of bladder carcinoma cells through the inactivation of Na+K+-ATPase. Abstract: Bufalin has been demonstrated to possess a wide range of pharmacological effects. Among these is its antitumour effect, which has been confirmed in multiple organs or tissues and …
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