Taylor Mercado

Bufalin suppresses the proliferation and metastasis of renal cell carcinoma.

PMID: Oncol Lett. 2018 Sep ;16(3):3867-3873. Epub 2018 Jul 10. PMID: 30128000 Abstract Title: Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway. Abstract: Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of …

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This data suggest potential applications of bufalin in therapy of prostate cancer in patients.

PMID: Mol Cancer Ther. 2018 11 ;17(11):2341-2352. Epub 2018 Aug 30. PMID: 30166403 Abstract Title: Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin. Abstract: Bufalin is a major cardiotonic compound in the traditional Chinese medicine, Chansu, prepared from toad skin secretions. Cell culture studies have suggested an anticancer …

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Bufalin enhances immune responses in leukemic mice.

PMID: In Vivo. 2018 Sep-Oct;32(5):1129-1136. PMID: 30150435 Abstract Title: Bufalin Enhances Immune Responses in Leukemic Mice Through Enhancing Phagocytosis of Macrophage. Abstract: BACKGROUND/AIM: Bufalin, bufadienolide present in Chan Su, has been shown to induce cancer cell apoptosis in many human cancer cells, including human leukemia cells, but its effects on immune responses are unknown.MATERIALS AND …

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Bufalin induces apoptotic cell death in human nasopharyngeal carcinoma cells.

PMID: Am J Chin Med. 2019 ;47(1):237-257. Epub 2019 Jan 7. PMID: 30612454 Abstract Title: Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways. Abstract: The aim of this study was to investigate the effects of bufalin on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro. Bufalin is …

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Bufalin engages in RIP1-dependent and ROS-dependent programmed necroptosis in breast cancer cells.

PMID: Anticancer Drugs. 2019 Aug ;30(7):e0770. PMID: 30829654 Abstract Title: Bufalin engages in RIP1-dependent and ROS-dependent programmed necroptosis in breast cancer cells by targeting the RIP1/RIP3/PGAM5 pathway. Abstract: Breast cancer causes high mortality among females worldwide. Bufalin has recently been shown to trigger tumor cell death, although the mechanism of cytotoxicity remains unclear. The cytotoxicity …

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Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats.

PMID: Arch Physiol Biochem. 2019 Sep 9:1-8. Epub 2019 Sep 9. PMID: 31496286 Abstract Title: Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats. Abstract: Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin on erythrocyte membrane …

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Crocus sativus extract containing polyphenols modulates oxidative stress and inflammatory response against anti-tuberculosis drugs-induced liver injury.

PMID: Plants (Basel). 2020 Jan 30 ;9(2). Epub 2020 Jan 30. PMID: 32019201 Abstract Title: L. Extract Containing Polyphenols Modulates Oxidative Stress and Inflammatory Response against Anti-Tuberculosis Drugs-Induced Liver Injury. Abstract: The purpose of this study is to analyze the polyphenolic rich extract ofL. petals (CSP) in modulating liver oxidative stress and inflammatory response status …

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Polyphenols in Alzheimer’s disease and in the gut-brain axis.

PMID: Microorganisms. 2020 Jan 31 ;8(2). Epub 2020 Jan 31. PMID: 32023969 Abstract Title: Polyphenols in Alzheimer's Disease and in the Gut-Brain Axis. Abstract: Polyphenolic antioxidants, including dietary plant lignans, modulate the gut-brain axis, which involves transformation of these polyphenolic compounds into physiologically active and neuroprotector compounds (called human lignans) through gut bacterial metabolism. These …

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These data support beneficial hypocholesterolemic and vascular effects of the daily consumption of proanthocyanidins-rich apples.

PMID: Am J Clin Nutr. 2020 Feb 1 ;111(2):307-318. PMID: 31840162 Abstract Title: Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial. Abstract: BACKGROUND: Apples are rich in bioactive polyphenols and fiber. Evidence suggests that consumption of apples or their bioactive components is associated …

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Young apple polyphenols as natural α-glucosidase inhibitors.

PMID: Bioorg Chem. 2020 Jan 28 ;96:103625. Epub 2020 Jan 28. PMID: 32028059 Abstract Title: Young apple polyphenols as naturalα-glucosidase inhibitors: In vitro and in silico studies. Abstract: In this study, the inhibitory activity of young apple polyphenols (YAP) onα-glucosidase was investigated. Composition and inhibition analyses suggested that tannic acid (TA), (-)-epicatechin (EC) and phlorizin …

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