PMID: Saudi J Biol Sci. 2020 Jan ;27(1):163-172. Epub 2019 Jun 19. PMID: 31889831 Abstract Title: Phytochemical profiling, antioxidant and HepG2 cancer cells' antiproliferation potential in the kernels of apricot cultivars. Abstract: Phytochemical composition, in vitro antioxidant and antiproliferative activity against HepG2 cells were studied in the kernels of apricot cultivars grown in the northern …
Author Archives: Taylor Mercado
Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma-induced liver toxicity.
PMID: Environ Sci Pollut Res Int. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31916166 Abstract Title: Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma-induced liver toxicity. Abstract: Vitamin B17 (VB17), also known as amygdalin and laetrile, is a type of carbohydrate occurring naturally in many plants, such as apricot kernels which have …
Bitter apricot ethanolic extract induces apoptosis in pancreatic cancer cells.
PMID: Mol Biol Rep. 2020 Feb 5. Epub 2020 Feb 5. PMID: 32026321 Abstract Title: Bitter apricot ethanolic extract induces apoptosis through increasing expression of Bax/Bcl-2 ratio and caspase-3 in PANC-1 pancreatic cancer cells. Abstract: Pancreatic cancer is the fourth common cause of cancer death. Surgery and chemotherapy are the common treatment strategies for pancreatic …
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Amygdalin is a natural anti-cancer agent which can be used for the treatment of hepatocellular carcinoma.
PMID: Anticancer Agents Med Chem. 2020 Jan 19. Epub 2020 Jan 19. PMID: 31958042 Abstract Title: Anticancer effect of Amygdalin (vitamin B17) on hepatocellular carcinoma cell line(HepG2) in the presence and absence of Zinc. Abstract: BACKGROUND: Amygdalin (Vitamin B-17) is a naturally occurring vitamin found in the seeds of the fruits of Prunus Rosacea family …
Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells.
PMID: Int J Biol Macromol. 2020 Jan 28 ;149:600-608. Epub 2020 Jan 28. PMID: 32004612 Abstract Title: Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells. Abstract: Fucoidan is a fucose-rich polysaccharide that has gained attention for its various anticancer properties. However, the effect and underlying mechanism of …
Urolithin A may exert neuroprotective effects and may aid in preventing D-gal-induced brain aging.
PMID: Neurotherapeutics. 2019 Oct ;16(4):1269-1282. PMID: 31420820 Abstract Title: Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. Abstract: Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs …
Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin.
PMID: J Ethnopharmacol. 2020 Mar 25 ;250:112479. Epub 2019 Dec 14. PMID: 31846746 Abstract Title: Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT/mTOR signaling pathway. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Urolithin A (UroA), the main intestinal microflora metabolite of ellagic acid of berries, …
The use of dietary urolithin A in cancer prevention or as adjuvant therapy is promising.
PMID: Mol Nutr Food Res. 2020 Jan 24:e1900390. Epub 2020 Jan 24. PMID: 31976617 Abstract Title: Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells. Abstract: SCOPE: Urolithin A (UA) is a gut-derived metabolite from ellagic acid found in pomegranates, berries and nuts can down-regulate cell proliferation and migration. Cell proliferation and …
Fisetin may improve the mitochondrial enzyme activity, thereby preventing the pathogenesis of Parkinson’s disease.
PMID: J Diet Suppl. 2020 Jan 29:1-15. Epub 2020 Jan 29. PMID: 31992104 Abstract Title: Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson's Disease. Abstract: Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD), particularly the inhibition of mitochondrial complex-I. This study aimed to …
Luteolin attenuates diabetic nephropathy through suppressing inflammatory response and oxidative stress.
PMID: Exp Clin Endocrinol Diabetes. 2020 Jan 2. Epub 2020 Jan 2. PMID: 31896157 Abstract Title: Luteolin Attenuates Diabetic Nephropathy through Suppressing Inflammatory Response and Oxidative Stress by Inhibiting STAT3 Pathway. Abstract: BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). DN has many pathological changes, but tubular injury is considered …
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