Author Archives: Taylor Mercado

PMID:  J Gene Med. 2020 Feb 6:e3169. Epub 2020 Feb 6. PMID: 32028542 Abstract Title:  Oleanolic acid mitigates interleukin-1β-induced chondrocyte dysfunction by regulating miR-148-3p-modulated FGF2 expression. Abstract:  BACKGROUND: microRNAs (miRs)-mediated post-transcriptional repression has been reported in the process of chondrocyte dysfunction. The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid …

Continue reading “Oleanolic acid mitigates interleukin-1β-induced chondrocyte dysfunction.”

PMID:  IUBMB Life. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31840927 Abstract Title:  Preventive effect of ursolic acid derivative on particulate matter 2.5-induced chronic obstructive pulmonary disease involves suppression of lung inflammation. Abstract:  Respiratory diseases like chronic obstructive pulmonary disease (COPD) are associated with the presence of particulate matter 2.5 (PM2.5) in the air. …

Continue reading “Preventive effect of ursolic acid derivative on particulate matter 2.5-induced chronic obstructive pulmonary disease.”

PMID:  Int J Mol Sci. 2019 Sep 23 ;20(19). Epub 2019 Sep 23. PMID: 31547587 Abstract Title:  Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer. Abstract:  The Hippo pathway is often dysregulated in many carcinomas, which results in various stages of tumor progression. Ursolic acid (UA), a natural compound …

Continue reading “Ursolic acid can be used as a potential chemopreventive and therapeutic agent for gastric cancer.”

PMID:  Int J Mol Sci. 2020 Jan 13 ;21(2). Epub 2020 Jan 13. PMID: 31941116 Abstract Title:  Licochalcone A InhibitsandGene Expression and Hypoxic Growth of Human Tumor Cell Lines. Abstract:  Hypoxic cellular proliferation is a common feature of tumor cells and is associated with tumor progression. Therefore, the inhibition of hypoxic cellular proliferation is expected …

Continue reading “Licochalcone A has therapeutic potential for malignant tumors including neuroblastoma and colorectal cancer.”

Can CBD cause liver damage?  If you watch the news you may have seen reports that CBD can cause liver damage.  This was very concerning to me, since I truly believe in the healing powers that CBD can provide.  So, I started doing some digging to find out why these news reports were popping up …

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PMID:  Inflammation. 2017 Dec ;40(6):1894-1902. PMID: 28756519 Abstract Title:  Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes. Abstract:  Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), has been reported to have anti-inflammatory activity. In this study, we evaluated the anti-inflammatory effects of Lico A on IL-1β-stimulated human osteoarthritis chondrocytes …

Continue reading “Licochalcone A showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signalling pathway.”

PMID:  Int J Mol Sci. 2017 Aug 12 ;18(8). Epub 2017 Aug 12. PMID: 28805696 Abstract Title:  Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress. Abstract:  Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis …

Continue reading “Licochalcone A inhibits the proliferation of human lung cancer cell lines A549 and H460.”

PMID:  Int J Mol Sci. 2017 Sep 22 ;18(10). Epub 2017 Sep 22. PMID: 28937602 Abstract Title:  Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson's Disease Models. Abstract:  The neuroprotective effects of Licochalcone A (Lico.A), a flavonoid isolated from the herb licorice, in Parkinson's disease (PD) have …

Continue reading “These results demonstrate for the first time that the neuroprotective effects of licochalcone A.”

PMID:  Cell Physiol Biochem. 2017 ;43(3):937-944. Epub 2017 Sep 29. PMID: 28957807 Abstract Title:  Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes. Abstract:  BACKGROUND: Osteoarthritis (OA) is a joint disease in which cartilage degradation is the central pathological change. In this study, we investigated the anti-osteoarthritic effects …

Continue reading “Licochalcone A may have therapeutic effects in osteoarthritis.”

PMID:  Biomed Pharmacother. 2017 Dec ;96:64-71. Epub 2017 Nov 24. PMID: 28965009 Abstract Title:  Licochalcone A induces morphological and biochemical alterations in Schistosoma mansoni adult worms. Abstract:  This paper is the first report on the in vitro effects of licochalcone A, a chalcone isolated from Glycyrrhiza inflate Batalin (Leguminosae), on Schistosoma mansoni adult worms. In …

Continue reading “Licochalcone A induces morphological and biochemical alterations in Schistosoma mansoni adult worms.”