PMID: Neuropharmacology. 2018 03 15 ;131:440-452. Epub 2017 Oct 28. PMID: 29111385 Abstract Title: JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid. Abstract: The mitogen-activated protein kinase family (MAPK) is an important group of enzymes involved in cellular responses to diverse external stimuli. One of the members …
Author Archives: Taylor Mercado
Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.
PMID: Free Radic Biol Med. 2018 02 1 ;115:471-483. Epub 2017 Dec 9. PMID: 29233793 Abstract Title: Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. Abstract: Licochalcone A (LCA) is derived from glycyrrhizae radix with antimicrobial, antitumor and anti-inflammatory activities. However, the anti-arthritic function of LCA and underlying …
Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
PMID: Oncol Rep. 2018 Mar ;39(3):1181-1190. Epub 2017 Dec 14. PMID: 29286170 Abstract Title: Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway. Abstract: Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose …
Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells
PMID: Oncol Lett. 2018 Feb ;15(2):1869-1873. Epub 2017 Nov 21. PMID: 29399197 Abstract Title: Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells. Abstract: Previous studies have demonstrated that Licochalcone A possesses anti-inflammatory, anticancer, anti-bacterial, anti-malarial and anti-parasitic activities. In the present study the potential anticancer effects of Licochalcone A …
Licochalcone A is effective in alleviating dextran sulphate sodium-induced colitis in mice.
PMID: Biomed Pharmacother. 2018 Jun ;102:922-929. Epub 2018 Apr 5. PMID: 29710547 Abstract Title: NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice. Abstract: Licochalcone A (Lico A) is a characteristic chalcone isolated from licorice root which is widely recognized in traditional Chinese medicine …
Antimicrobial effect of Licochalcone A and Epigallocatechin-3-gallate against Salmonella Typhimurium isolated from poultry flocks.
PMID: Iran J Microbiol. 2018 Feb ;10(1):51-58. PMID: 29922419 Abstract Title: Antimicrobial effect of Licochalcone A and Epigallocatechin-3-gallate againstTyphimurium isolated from poultry flocks. Abstract: Background and Objectives: Salmonellosis due to multi-drug resistantTyphimurium with biofilm formation ability is a serious public health threat worldwide. Studies have shown that medicinal plants inhibit the growth of bacterial species. …
Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning.
PMID: Biochem Biophys Res Commun. 2018 09 10 ;503(3):2117-2123. Epub 2018 Aug 7. PMID: 30093114 Abstract Title: Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning. Abstract: The main function of brown adipose tissue is to dissipate surplus caloric intake into heat energy by thermogenesis, increasing energy expenditure. Inducible brown adipocytes …
Licochalcone A might be a potential medical therapy for small abdominal aortic aneurysm.
PMID: J Cell Physiol. 2019 May ;234(5):7560-7568. Epub 2018 Nov 11. PMID: 30417353 Abstract Title: Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling. Abstract: Licochalcone A (LA), a chalcone derived from liquorice, exhibits multiple biological activities, including anti-oxidation and anti-inflammation. This study aimed to investigate the role and …
Licochalcone A protects the blood–milk barrier integrity and relieves the inflammatory response in LPS-induced mastitis.
PMID: Front Immunol. 2019 ;10:287. Epub 2019 Feb 25. PMID: 30858849 Abstract Title: Licochalcone A Protects the Blood-Milk Barrier Integrity and Relieves the Inflammatory Response in LPS-Induced Mastitis. Abstract: Mastitis is an acute clinical inflammatory response. The occurrence and development of mastitis seriously disturb women's physical and mental health. Licochalcone A, a phenolic compound in, …
Enrichment of total flavones and licochalcone A from licorice residues and its hypoglycemic activity.
PMID: J Chromatogr B Analyt Technol Biomed Life Sci. 2019 May 1 ;1114-1115:134-145. Epub 2019 Jan 31. PMID: 30878379 Abstract Title: Enrichment of total flavones and licochalcone A from licorice residues and its hypoglycemic activity. Abstract: Industrial processing of glycyrrhizic leads to a lot of residues which are usually threw away randomly or used as …
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