PMID: Chin J Integr Med. 2019 Sep ;25(9):691-695. Epub 2019 Oct 24. PMID: 31650487 Abstract Title: Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis. Abstract: OBJECTIVE: To determine the changes in serum levels of inflammatory biomarkers and antioxidant levels among the …
Author Archives: Taylor Mercado
New applications of oleanolic acid and its derivatives as cardioprotective agents.
PMID: Curr Pharm Des. 2019 ;25(35):3740-3750. PMID: 31692428 Abstract Title: New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives. Abstract: Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five …
Oleanolic acid improves diabetes-induced haematological changes caused by hyperglycaemia and attenuates the progression of cardiovascular complications.
PMID: J Diabetes Res. 2019 ;2019:6753541. Epub 2019 Nov 19. PMID: 31828165 Abstract Title: The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers. Abstract: Background: Sustained hyperglycaemia leads to the development of haematological alterations which, if left untreated, is associated with cardiovascular complications. Insulin is the mainstay drug in type …
Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea.
PMID: Food Funct. 2020 Jan 29 ;11(1):1122-1132. PMID: 31825448 Abstract Title: Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway. Abstract: Salmonella typhimurium (S.T) is a common cause of acute, self-limiting food-borne diarrhea with severe intestinal inflammation and intestinal barrier damage. Oleanolic acid (OA), …
Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells.
PMID: Drug Deliv. 2020 Dec ;27(1):191-199. PMID: 31924110 Abstract Title: Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance. Abstract: Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of …
Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis
PMID: Biomed Pharmacother. 2020 Mar ;123:109752. Epub 2020 Jan 8. PMID: 31924596 Abstract Title: Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs. Abstract: Spinal cord injury (SCI) is reported as a devastating disease, leading to tissue loss and neurologic dysfunction. However, there is …
Phyllanthus amarus protects against spatial memory impairment induced by lipopolysaccharide in mice.
PMID: Bioinformation. 2019 ;15(8):535-541. Epub 2019 Aug 31. PMID: 31719762 Abstract Title: Phyllanthus amarus protects against spatial memory impairment induced by lipopolysaccharide in mice. Abstract: Phyllanthus amarus Schumach. and Thonn. is a wide spread medicinal herb with various traditional uses. It is well documented for its antioxidant, anti-inflammatory, and hepatoprotective activities. Therefore, it is of …
Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma.
PMID: J Cancer. 2019 ;10(23):5820-5831. Epub 2019 Oct 6. PMID: 31737119 Abstract Title: Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma. Abstract: Ursolic acid (UA) is widely found in many dietary plants, which has been proved to be effective in cancer therapy. But unfortunately its hydrophobic property limits its clinical application. …
Ursolic acid improves intestinal damage and bacterial dysbiosis in liver fibrosis mice.
PMID: Front Pharmacol. 2019 ;10:1321. Epub 2019 Nov 1. PMID: 31736766 Abstract Title: Ursolic Acid Improves Intestinal Damage and Bacterial Dysbiosis in Liver Fibrosis Mice. Abstract: Liver fibrosis is a reversible process of extracellular matrix deposition or scar formation after liver injury. Intestinal damage and bacterial dysbiosis are important concomitant intestinal changes in liver fibrosis …
Antibacterial and antibiofilm activity of ursolic acid against carbapenem-resistant Enterobacter cloacae.
PMID: J Biosci Bioeng. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31813671 Abstract Title: Antibacterial and antibiofilm activity of ursolic acid against carbapenem-resistant Enterobacter cloacae. Abstract: Recent studies demonstrate that ursolic acid (UA) presents potent antimicrobial activity against a few microorganisms, however, the underlying mechanisms remain elusive. Moreover, little is known about the effect …
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