PMID: J Med Food. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31747348 Abstract Title: Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression. Abstract: Excess of visceral adipose tissue (VAT) characteristic of obesity leads to a proinflammatory state disrupting the insulin signaling pathway, triggering insulin …
Author Archives: Taylor Mercado
Ursolic acid treatment alleviates diabetic kidney injury.
PMID: Diabetes Metab Syndr Obes. 2019 ;12:2597-2608. Epub 2019 Dec 9. PMID: 31849504 Abstract Title: Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway. Abstract: Purpose: This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein …
Continue reading “Ursolic acid treatment alleviates diabetic kidney injury.”
Ursolic acid could attenuate the stemness and chemoresistance of non-small cell lung cancer cells.
PMID: Environ Toxicol. 2019 Dec 19. Epub 2019 Dec 19. PMID: 31855318 Abstract Title: The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells. Abstract: Although the inhibitory roles of ursolic acid (UA) have been established in various tumors, its effects on the stemness of …
Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy.
PMID: J Control Release. 2020 Jan 8 ;320:168-178. Epub 2020 Jan 8. PMID: 31926193 Abstract Title: Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy. Abstract: Ursolic acid (UA) is a potent triterpenoid compound found in plants and fruits with activities modulating key cell signaling pathways involving …
Ellagic acid protects Caco-2 cell monolayers against inflammation-induced permeabilization.
PMID: Free Radic Biol Med. 2020 Jan 23. Epub 2020 Jan 23. PMID: 31981623 Abstract Title: Ellagic acid protects Caco-2 cell monolayers against inflammation-induced permeabilization. Abstract: Chronic intestinal inflammation involves a cycle of oxidative stress, activation of redox sensitive transcription factors, and barrier permeabilization. The latter can lead to systemic inflammation and its associated co-morbidities. …
Phyllanthus amarus exerts various anticancer and anti-inflammatory activities.
PMID: Inflammopharmacology. 2020 Feb ;28(1):1-18. Epub 2019 Dec 2. PMID: 31792765 Abstract Title: Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer. Abstract: The causal and functional connection between inflammation and cancer has become a subject of much research interest. Modulation …
Continue reading “Phyllanthus amarus exerts various anticancer and anti-inflammatory activities.”
Effect of Andrographis paniculata and Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity.
PMID: Drug Chem Toxicol. 2020 Jan 3:1-10. Epub 2020 Jan 3. PMID: 31899970 Abstract Title: Effect ofandleaf extracts on selected biochemical indices inmodel of neurotoxicity. Abstract: Aluminum (Al)-induced toxicity in fruit fly (is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the …
Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis.
PMID: J Bodyw Mov Ther. 2020 Jan ;24(1):15-18. Epub 2019 May 4. PMID: 31987536 Abstract Title: Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial. Abstract: OBJECTIVE: This study examined the effects of treatment with Phyllanthus amarus nanoparticle gel applied by phonophoresis (PP) and ultrasound therapy …
Matricaria chamomilla extract ameliorated hypothyroidism associated with polycystic ovary syndrome.
PMID: Biomolecules. 2020 Jan 5 ;10(1). Epub 2020 Jan 5. PMID: 31948119 Abstract Title: Bothand Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism. Abstract: There is increasing proof that polycystic ovary syndrome (PCOS) is associated with the increased frequency of thyroid disturbances. Chamomile (L.) …
These findings extend the novel functions of chamomile in the improvement of glycemic and lipid profiles and oxidative stress in diabetes mellitus.
PMID: Complement Ther Med. 2020 Jan ;48:102284. Epub 2019 Dec 17. PMID: 31987240 Abstract Title: Chamomile (Matricaria recutita L.) and diabetes mellitus, current knowledge and the way forward: A systematic review. Abstract: Chamomile, as a rich source of phenolic compounds and terpenoids, seems to be an effective approach in the management of chronic conditions such …
Health Time 