PMID: Biochem Biophys Res Commun. 2019 Dec 10 ;520(3):580-585. Epub 2019 Oct 14. PMID: 31623833 Abstract Title: Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia. Abstract: BACKGROUND: Diabetes is a strong risk factor of peripheral arterial disease (PAD), and also leads to impaired perfusion recovery in the ischemic limb, which eventually results in poor …
Author Archives: Taylor Mercado
Tanshinone ⅡA inhibits homocysteine-induced proliferation of vascular smooth muscle cells.
PMID: Biochem Biophys Res Commun. 2020 Jan 29 ;522(1):157-163. Epub 2019 Nov 19. PMID: 31757424 Abstract Title: TanshinoneⅡA inhibits homocysteine-induced proliferation of vascular smooth muscle cells via miR-145/CD40 signaling. Abstract: Tanshinone IIA (Tan IIA), isolated from the traditional Chinese herb Danshen, exhibits broad cardiovascular protective effects. However, the effect of Tan IIA on Homocysteine (Hcy)-induced …
Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer.
PMID: Int J Mol Sci. 2019 Dec 30 ;21(1). Epub 2019 Dec 30. PMID: 31905926 Abstract Title: Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer. Abstract: The role of metastasis-related genes in cisplatin (CDDP) chemoresistance in gastric cancer is poorly understood. Here, we examined the expression of four metastasis-related genes (namely,,,,) in 39 …
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Tanshinone IIA reverses oxaliplatin resistance in human colorectal cancer.
PMID: Onco Targets Ther. 2019 ;12:9725-9734. Epub 2019 Nov 14. PMID: 32009805 Abstract Title: Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway. Abstract: Background: Oxaliplatin (OXA)-based chemotherapy is generally used to treat human cancers, whereas OXA resistance is a main obstacle for the treatment of colorectal cancer (CRC). …
Continue reading “Tanshinone IIA reverses oxaliplatin resistance in human colorectal cancer.”
Tanshinone IIA improves depression-like behavior in mice.
PMID: Neuroscience. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32014436 Abstract Title: Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Abstract: Depression is a serious global affective disorder and one of the most common neurological diseases. Tanshinone IIA (TSA) is the mainly active constituent of Salvia miltiorrhiza and has …
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Astaxanthin treatment stimulated mitochondrial biogenesis and significantly ameliorated insulin resistance.
PMID: J Cachexia Sarcopenia Muscle. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32003547 Abstract Title: Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway. Abstract: BACKGROUND: Skeletal muscle is mainly responsible for insulin-stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), …
Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis.
PMID: Pharmacol Rep. 2020 Feb ;72(1):104-114. Epub 2019 Dec 19. PMID: 32016833 Abstract Title: Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Abstract: BACKGROUND: Astaxanthin (ATX), a natural xanthophyll carotenoid, has shown to exert significant protective effects against various diseases via its antioxidant and anti-inflammatory properties. However, its potential role …
Humulus japonicus stimulates thermogenesis and ameliorates oxidative stress in mouse adipocytes.
PMID: J Mol Endocrinol. 2019 Jul 1 ;63(1):1-9. PMID: 30978698 Abstract Title: Humulus japonicus stimulates thermogenesis and ameliorates oxidative stress in mouse adipocytes. Abstract: An aqueous extract of Humulus japonicus (AH) has been documented to ameliorate hypertension and non-alcoholic fatty liver disease (NAFLD). Here, we investigated the effects of an aqueous extract of AH on …
Humulus japonicus extract ameliorates collagen‑induced arthritis.
PMID: Int J Mol Med. 2020 Feb ;45(2):417-428. Epub 2019 Dec 3. PMID: 31894253 Abstract Title: Humulus japonicus extract ameliorates collagen‑induced arthritis in mice through regulation of overall articular inflammation. Abstract: Humulus japonicus (HJ) is a widely used herbal medicine in Asia with anti‑oxidative, anti‑microbial, and anti‑inflammatory effects. We investigated the potential therapeutic effects of …
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Turmeric May Improve Heart-Related Symptoms of Type 2 Diabetes
A study finds that Curcuma longa, more popularly known as turmeric, can alleviate certain symptoms of Type 2 diabetes, namely arterial stiffness and endothelial dysfunction
Health Time 