PMID: Oxid Med Cell Longev. 2019 ;2019:3643715. Epub 2019 Dec 13. PMID: 31915505 Abstract Title: The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression. Abstract: Background: Metastasis and invasion are the main causes of mortality in gastric cancer. To improve the treatment of gastric …
Author Archives: Taylor Mercado
Potential protective role of rutin and alpha-lipoic acid against cisplatin-induced nephrotoxicity.
PMID: Pak J Biol Sci. 2019 Jan ;22(8):361-371. PMID: 31930824 Abstract Title: Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats. Abstract: BACKGROUND AND OBJECTIVE: Cisplatin-induced nephrotoxicity is a serious complication that restricts its utilization in cancer treatment. Rutin and alpha-lipoic acid have antioxidant effectiveness, anti-inflammatory efficacy and prevent oxidative stress. …
Effect of α-lipoic acid on spatial memory and structural integrity of developing hippocampal neurons in rats subjected to sodium arsenite exposure.
PMID: Environ Toxicol Pharmacol. 2020 Jan 7 ;75:103323. Epub 2020 Jan 7. PMID: 31935550 Abstract Title: Effect ofα-lipoic acid on spatial memory and structural integrity of developing hippocampal neurons in rats subjected to sodium arsenite exposure. Abstract: BACKGROUND: Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various …
Improving the concentration of lutein in the retina could protect retinal pigment epithelium from diabetes-associated damage.
PMID: J Cell Commun Signal. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31820335 Abstract Title: Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE-19) cells. Abstract: Diabetic retinopathy (DR) is a major cause of acquired blindness among working adults. The retinal pigment epithelium …
The ginsenoside metabolite 20(S)-Protopanaxatriol inhibits inflammation-mediated inflammasome activation.
PMID: J Ethnopharmacol. 2020 Jan 10 ;251:112564. Epub 2020 Jan 10. PMID: 31926987 Abstract Title: Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng C.A. Meyer (Araliaceae), has been used in traditional medicine for preventive and therapeutic purposes in Asian countries. One of the active ginsenoside metabolites, 20(S)-Protopanaxatriol …
A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.
PMID: Evid Based Complement Alternat Med. 2019 ;2019:2417418. Epub 2019 Dec 17. PMID: 31929811 Abstract Title: Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review. Abstract: Objective: In China, ginsenoside Rg3 is often used in combination with chemotherapy to treat digestive system cancer. We here performed …
A critical regulation of Th17 cell responses and autoimmune neuro-inflammation by ginsenoside Rg3.
PMID: Biomolecules. 2020 Jan 10 ;10(1). Epub 2020 Jan 10. PMID: 31936879 Abstract Title: A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3. Abstract: Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in diverse autoimmune diseases, and thus, targeting Th17 cells could be beneficial for the treatment of …
Improving Alzheimer’s disease by altering gut microbiota in tree shrews with ginsenoside Rg1.
PMID: FEMS Microbiol Lett. 2020 Jan 17. Epub 2020 Jan 17. PMID: 31950993 Abstract Title: Improving Alzheimer's disease by altering Gut Microbiota in tree shrews with ginsenoside Rg1. Abstract: Ginsenoside Rg1 (GRg1) has neuroprotective effects on Alzheimer's disease (AD). The occurrence and progression of AD are closely related to gut microbiota. Few studies have learned …
Ginsenoside protects against AKI via activation of HIF 1α and VEGF A in the kidney brain axis.
PMID: Int J Mol Med. 2020 Jan 15. Epub 2020 Jan 15. PMID: 31985021 Abstract Title: Ginsenoside protects against AKI via activation of HIF‑1α and VEGF‑A in the kidney‑brain axis. Abstract: Acute kidney injury (AKI) is characterized by abrupt kidney dysfunction. It results in remote organ dysfunction, including the brain. The underlying mechanism of the …
Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury.
PMID: Biomed Pharmacother. 2020 Jan 28 ;125:109913. Epub 2020 Jan 28. PMID: 32006902 Abstract Title: Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury through mTOR signal pathway. Abstract: OBJECTIVE: Ginsenoside Rb1 (GRb1) is known to play an effective protection on myocardial infarction, yet its therapeutic mechanism on myocardial ischemia/reperfusion (I/R) injury has …
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