PMID: Adv Neurobiol. 2020 ;24:615-646. PMID: 32006377 Abstract Title: Dietary Phytochemicals as Neurotherapeutics for Autism Spectrum Disorder: Plausible Mechanism and Evidence. Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with symptoms ranging from lack of social interaction and communication deficits to rigid, repetitive, and stereotypic behavior. It has also been associated with comorbidities …
Author Archives: Taylor Mercado
Bauerane inhibited the proliferation of A549 lung cancer cells in vitro and induced cell apoptosis and cell cycle arrest in a dose-dependent manner.
PMID: Med Sci Monit. 2020 Feb 1 ;26:e919558. Epub 2020 Feb 1. PMID: 32005795 Abstract Title: Bauerane Induces S-Phase Cell Cycle Arrest, Apoptosis, and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway. Abstract: BACKGROUND Bauerane is a triterpenoid …
Inhibitory effects of myricetin on lipopolysaccharide-induced neuroinflammation.
PMID: Brain Sci. 2020 Jan 6 ;10(1). Epub 2020 Jan 6. PMID: 31935983 Abstract Title: Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation. Abstract: Microglial activation elicits an immune response by producing proinflammatory modulators and cytokines that cause neurodegeneration. Therefore, a plausible strategy to prevent neurodegeneration is to inhibit neuroinflammation caused by microglial activation. Myricetin, a …
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Myricetin has antiproliferative effects on endometriosis through cell cycle regulation.
PMID: J Nutr Biochem. 2019 Dec 23 ;78:108328. Epub 2019 Dec 23. PMID: 31952013 Abstract Title: Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo. Abstract: Endometriosis is a benign gynecological condition prevalent among reproductive-aged women. Although active research and studies have been carried out to discover new drugs, surgery and …
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.
PMID: Bioorg Med Chem Lett. 2012 Jun 15 ;22(12):4049-54. Epub 2012 Apr 25. PMID: 22578462 Abstract Title: Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Abstract: Severe acute respiratory syndrome (SARS) is an infectious disease with a strong potential for transmission upon close personal contact and is caused …
Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis.
PMID: Exp Physiol. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32003913 Abstract Title: Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. Abstract: NEW FINDINGS: What is the central question of this study? Prolonged stress exposure induces detrimental changes in the brain structure, and increases the …
This review attempts to provide a summary of the main molecular mechanisms involved in flavonoid radio-protective effects.
PMID: Adv Pharm Bull. 2020 Jan ;10(1):13-19. Epub 2019 Dec 11. PMID: 32002357 Abstract Title: An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects. Abstract: Considering the remarkable application of radiotherapy in the treatment and diagnosis of various diseases and even nuclear war, it is important to protect healthy tissues and people at risk …
Effective inhibition of MERS-CoV infection by resveratrol
PMID: BMC Infect Dis. 2017 02 13 ;17(1):144. Epub 2017 Feb 13. PMID: 28193191 Abstract Title: Effective inhibition of MERS-CoV infection by resveratrol. Abstract: BACKGROUND: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines …
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Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate.
PMID: Evid Based Complement Alternat Med. 2005 06 ;2(2):209-215. Epub 2005 Apr 7. PMID: 15937562 Abstract Title: Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3). Abstract: SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS). The virally encoded 3C-like protease (3CL(Pro)) has been presumed critical for the viral replication of SARS-CoV in …
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Our data reveal the novel metabolic pathways modulated by black raspberries phytochemicals that can be targeted during the chemoprevention of oral cancer.
PMID: Metabolites. 2019 Jul 11 ;9(7). Epub 2019 Jul 11. PMID: 31336728 Abstract Title: Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention. Abstract: Oral cancer is a public health problem with an incidence of almost 50,000 and a mortality of 10,000 each year in the USA alone. …
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