Author Archives: Taylor Mercado

PMID:  Mol Med Rep. 2020 Feb ;21(2):641-648. Epub 2019 Dec 17. PMID: 31974615 Abstract Title:  Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response. Abstract:  Crocetin, a natural compound, has been demonstrated to exhibit beneficial effects in cardiovascular diseases. Previous studies demonstrated that crocetin reduced ischemia/reperfusion (I/R) injury by attenuating cytotoxicity …

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PMID:  Neural Regen Res. 2020 Aug ;15(8):1408-1416. PMID: 31997799 Abstract Title:  Beneficial effects of saffron (L.) in ocular pathologies, particularly neurodegenerative retinal diseases. Abstract:  Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as …

Continue reading “Beneficial effects of saffron in ocular pathologies, particularly neurodegenerative retinal diseases.”

PMID:  Environ Sci Pollut Res Int. 2020 Jan 22. Epub 2020 Jan 22. PMID: 31965510 Abstract Title:  Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues. Abstract:  Chlorpyrifos is an organophosphate pesticide whose exposure leads to inhibition of acetylcholinesterase (AChE) enzyme and induces oxidative stress, inflammation, and neurotoxicity. The current …

Continue reading “Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues.”

PMID:  Cancers (Basel). 2020 Jan 22 ;12(2). Epub 2020 Jan 22. PMID: 31979093 Abstract Title:  Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin. Abstract:  Resistance to chemotherapy and radiation therapy is considered a major therapeutic barrier in breast cancer. Cancer stem cells (CSCs) play …

Continue reading “Phenethyl isothiocyanate suppresses stemness in the chemo- and radio-resistant triple-negative breast cancer cells.”

PMID:  Eur J Med Chem. 2020 Feb 1 ;187:111951. Epub 2019 Dec 4. PMID: 31821990 Abstract Title:  Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance. Abstract:  Gynaecological disorders, such as cervical, ovarian, and endometrial cancers are the second most prevalent cancer types in women worldwide. Therapeutic approaches for gynaecological cancers …

Continue reading “Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance.”

PMID:  J BUON. 2019 Sep-Oct;24(5):1870-1875. PMID: 31786849 Abstract Title:  Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway. Abstract:  PURPOSE: Berbamine is a plant-derived alkaloid with amazing and wide diversity of pharmacological properties which range from antimicrobial and anticancer. Nonetheless, the …

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PMID:  Onco Targets Ther. 2019 ;12:11437-11451. Epub 2019 Dec 24. PMID: 31920333 Abstract Title:  Berbamine Enhances the Efficacy of Gefitinib by Suppressing STAT3 Signaling in Pancreatic Cancer Cells. Abstract:  Background: Small molecular inhibitors such as gefitinib (Gefi), which target EGF receptor (EGFR), are considered to be a viable pathway for the selective inhibition of pancreatic …

Continue reading “Berbamine enhances the efficacy of gefitinib by suppressing STAT3 signalling in pancreatic cancer cells.”

PMID:  Environ Sci Pollut Res Int. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31845254 Abstract Title:  Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat. Abstract:  Paraquat (PQ) is a herbicide agent commonly used in agricultural applications. Hepatotoxicity is among clinical complications associated with PQ intoxication. Oxidative stress and its subsequent events are …

Continue reading “Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat.”

PMID:  Appl Microbiol Biotechnol. 2020 Feb ;104(4):1737-1749. Epub 2019 Dec 23. PMID: 31867696 Abstract Title:  Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats. Abstract:  Intestinal flora imbalance is one of the potential pathogenesis of inflammatory bowel diseases, and the study aims to discover the effect of …

Continue reading “Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats.”

PMID:  Biochem Pharmacol. 2019 Dec 23 ;174:113776. Epub 2019 Dec 23. PMID: 31874145 Abstract Title:  Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis. Abstract:  Lipid metabolism is a significant section of energy homeostasis, and it affects the development of various cancers. Previous studies have revealed that berberine has strong anticancer …

Continue reading “Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis.”