PMID: Biomed Pharmacother. 2019 Dec 23 ;123:109794. Epub 2019 Dec 23. PMID: 31874443 Abstract Title: Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells. Abstract: Renal cell carcinoma (RCC) consists of the most lethal common urological cancer and the clinical practice has shown that resistant RCC to commons therapies …
Author Archives: Taylor Mercado
Berberine ameliorates doxorubicin-induced cardiotoxicity.
PMID: Oxid Med Cell Longev. 2019 ;2019:2150394. Epub 2019 Dec 6. PMID: 31885776 Abstract Title: Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway. Abstract: Doxorubicin- (DOX-) induced cardiotoxicity is associated with oxidative stress and cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status and determines cell susceptibility to apoptosis. This study is aimed …
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Berberine significantly inhibits atherosclerotic disease development by regulating lipid homeostasis and suppressing macrophage foam cell formation.
PMID: J Cardiovasc Pharmacol. 2020 Jan ;75(1):45-53. PMID: 31895879 Abstract Title: Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway. Abstract: Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived …
Combined use of astragalus polysaccharide and berberine attenuates insulin resistance.
PMID: Front Pharmacol. 2019 ;10:1508. Epub 2019 Dec 23. PMID: 31920677 Abstract Title: Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 CellsRegulation of the Gluconeogenesis Signaling Pathway. Abstract: Insulin resistance (IR) is likely to induce metabolic syndrome and type 2 diabetes mellitus (T2DM). Gluconeogenesis (GNG) is a complex metabolic process that …
Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.
PMID: Lancet Gastroenterol Hepatol. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31926918 Abstract Title: Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. Abstract: BACKGROUND: Chemoprevention of colorectal adenoma and colorectal cancer remains an important public health goal. The present study aimed to investigate the clinical …
Preventive and therapeutic roles of berberine in gastrointestinal cancers.
PMID: Biomed Res Int. 2019 ;2019:6831520. Epub 2019 Dec 28. PMID: 31950049 Abstract Title: Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers. Abstract: Berberine (BBR) is an isoquinoline alkaloid isolated from various types of plants, including those from the Berberidaceae, Ranunculaceae, and Papaveraceae families. It has long been used in traditional Chinese medicine for …
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Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.
PMID: Chem Biol Interact. 2020 Jan 20 ;317:108947. Epub 2020 Jan 20. PMID: 31968208 Abstract Title: Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases. Abstract: Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and …
Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic mice
PMID: Oxid Med Cell Longev. 2020 ;2020:6210526. Epub 2020 Jan 3. PMID: 31976031 Abstract Title: Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice. Abstract: Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main cause of persistent hyperglycemia in type 2 diabetes. Berberine (Zhang et al., 2010) has been …
Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells.
PMID: Life Sci. 2020 Jan 22 ;244:117346. Epub 2020 Jan 22. PMID: 31978448 Abstract Title: Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. Abstract: AIM: Emerging studies have shown that application of low concentration of bioactive phytomolecules can confer anti-proliferative effects on tumour …
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Berberine impairs the survival of triple negative breast cancer cells.
PMID: Molecules. 2020 Jan 24 ;25(3). Epub 2020 Jan 24. PMID: 31991634 Abstract Title: Berberine Impairs the Survival of Triple Negative Breast Cancer Cells: Cellular and Molecular Analyses. Abstract: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Non-available targeted therapy for TNBC represents its biggest treatment challenge. Thus, finding new promising effective …
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