Author Archives: Taylor Mercado

PMID:  PPAR Res. 2019 ;2019:2601408. Epub 2019 Dec 17. PMID: 31933619 Abstract Title:  Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-in Mice. Abstract:  Background: Oxidative stress, inflammation and cardiac apoptosis were closely involved in doxorubicin (DOX)-induced cardiac injury. Piperine has been reported to suppress inflammatory response and pyroptosis in macrophages. However, whether piperine could protect the …

Continue reading “Piperine alleviates doxorubicin-induced cardiotoxicity.”

PMID:  J BUON. 2019 Nov-Dec;24(6):2316-2321. PMID: 31983100 Abstract Title:  Piperine alkaloid induces anticancer and apoptotic effects in cisplatin resistant ovarian carcinoma by inducing G2/M phase cell cycle arrest, caspase activation and inhibition of cell migration and PI3K/Akt/GSK3β signalling pathway. Abstract:  PURPOSE: Ovarian cancer is one the prevalent cancers in women and is responsible for 5% …

Continue reading “Piperine alkaloid induces anticancer and apoptotic effects in cisplatin resistant ovarian carcinoma.”

PMID:  Front Pharmacol. 2019 ;10:289. Epub 2019 Apr 26. PMID: 31105555 Abstract Title:  ARoot Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling. Abstract:  , commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle …

Continue reading “A Symphytum officinale root extract exerts anti-inflammatory properties by affecting two distinct steps of NF-κB signalling.”

PMID:  Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan 21:158635. Epub 2020 Jan 21. PMID: 31978554 Abstract Title:  The role ofβ-carotene and vitamin A in atherogenesis: Evidences from pre-clinical and clinical studies. Abstract:  Atherosclerotic cardiovascular disease (ASCVD) is the principal contributor to myocardial infarction, the leading cause of death worldwide. Epidemiological and mechanistic studies …

Continue reading “The role of β-carotene and vitamin A in atherogenesis: Evidences from pre-clinical and clinical studies.”

PMID:  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Jul ;35(7):625-630. PMID: 31537248 Abstract Title:  [Folic acid relieves rat cardiomyocyte injury induced by homocystein through DNA methylation]. Abstract:  Objective To investigate the effect of homocysteine (Hcy) on the cardiomyocytes cultured in vitro, and to analyze the role of folic acid in DNA …

Continue reading “Folic acid relieves rat cardiomyocyte injury induced by homocystein through DNA methylation.”

PMID:  Environ Pollut. 2019 Dec ;255(Pt 3):113331. Epub 2019 Oct 8. PMID: 31614245 Abstract Title:  PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Abstract:  We previously found that folic acid (FA) attenuated cardiac defects in zebrafish embryos exposed to extractable organic matter (EOM) from PM2.5, …

Continue reading “PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid.”

PMID:  Neurotox Res. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31721048 Abstract Title:  Folic Acid Protects Rat Cerebellum Against Oxidative Damage Caused by Homocysteine: the Expression of Bcl-2, Bax, and Caspase-3 Apoptotic Genes. Abstract:  There is evidence that oxidative stress involves in homocysteine-induced pathogenesis. Considering the antioxidative properties of folic acid and its involvement …

Continue reading “Folic acid can protect cerebellum against homocysteine-mediated neurotoxicity.”

PMID:  Biosci Rep. 2019 Nov 29 ;39(11). PMID: 31670376 Abstract Title:  Homocysteine and psoriasis. Abstract:  Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). …

Continue reading “Homocysteine can be a potential therapeutic target for the treatment of psoriasis.”

PMID:  Aging (Albany NY). 2019 Nov 22 ;11(22):10356-10373. Epub 2019 Nov 22. PMID: 31757935 Abstract Title:  Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism. Abstract:  The occurrence of telomere attrition in brain may cause senescence and death of neurons, leading to cognitive decline. Folic acid …

Continue reading “Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.”

PMID:  BMC Neurosci. 2020 Jan 15 ;21(1):1. Epub 2020 Jan 15. PMID: 31941442 Abstract Title:  Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress. Abstract:  BACKGROUND: Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, …

Continue reading “Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress”