Author Archives: Taylor Mercado

PMID:  Gut Microbes. 2020 May 6:1-14. Epub 2020 May 6. PMID: 32372706 Abstract Title:  Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes. Abstract:  The understanding of the effects of compounds on the gut microbiome is limited. In particular, it is unclear whether structurally similar compounds would have similar …

Continue reading “Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes.”

PMID:  Complement Ther Clin Pract. 2020 May ;39:101113. Epub 2020 Feb 1. PMID: 32379652 Abstract Title:  The effect of berberine supplementation on obesity indices: A dose- response meta-analysis and systematic review of randomized controlled trials. Abstract:  BACKGROUND: and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent …

Continue reading “The results of the current study support the use of berberine supplementation for the improvement of obesity indices.”

PMID:  Oxid Med Cell Longev. 2020 ;2020:2963020. Epub 2020 Mar 9. PMID: 32215171 Abstract Title:  Red Beetroot Extract Abrogates Chlorpyrifos-Induced Cortical Damage in Rats. Abstract:  Organophosphorus insecticides including chlorpyrifos (CPF) are mainly used for agriculture, household, and military purposes; their application is associated with various adverse reactions in animals and humans. This study was conducted …

Continue reading “Red beetroot extract abrogates chlorpyrifos-induced cortical damage.”

PMID:  J Physiol. 2020 May 5. Epub 2020 May 5. PMID: 32368787 Abstract Title:  Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOSmice: importance of nitrate-independent effects. Abstract:  KEY POINTS: Maternal hypertension is associated with increased rates of pregnancy pathologies, including fetal growth restriction, due at least in part to reductions in …

Continue reading “Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOS-/- mice”

PMID:  Biofactors. 2017 Jul 8 ;43(4):567-576. Epub 2017 May 16. PMID: 28509396 Abstract Title:  Anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin-sensitized rat. Abstract:  BACKGROUND: Anti-inflammatory and antioxidant properties of curcumin have been shown. In this study, anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in sensitized rat were evaluated.METHODS: Six groups of rats including …

Continue reading “Anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin-sensitized rat.”

PMID:  BMC Vet Res. 2020 Feb 5 ;16(1):44. Epub 2020 Feb 5. PMID: 32024502 Abstract Title:  Betulinic acid shows anticancer activity against equine melanoma cells and permeates isolated equine skin in vitro. Abstract:  BACKGROUND: Equine malignant melanoma (EMM) is a frequently occurring dermoepidermal tumor in grey horses. Currently available therapies are either challenging or inefficient. …

Continue reading “Betulinic acid shows anticancer activity against equine melanoma cells and permeates isolated equine skin in vitro.”

PMID:  J Biomed Nanotechnol. 2020 Feb 1 ;16(2):235-251. PMID: 32252884 Abstract Title:  The Antitumor Activity of Betulinic Acid-Loaded Nanoliposomes Against Colorectal Cancerandvia Glycolytic and Glutaminolytic Pathways. Abstract:  The purpose of this study is to develop betulinic acid loaded nanoliposomes to improve the chemotherapy effect of colorectal cancer. The cellular uptake and anti-tumor effects of betulinic …

Continue reading “The antitumor activity of betulinic acid-loaded nanoliposomes against colorectal cancer.”

PMID:  Cell Biochem Funct. 2020 Apr 13. Epub 2020 Apr 13. PMID: 32283563 Abstract Title:  Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress. Abstract:  Gastric cancer (GC) is one of the most prevalent types of malignancies. Betulinic acid (BA) is a natural pentacyclic triterpene with a …

Continue reading “Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.”

PMID:  Cancers (Basel). 2020 Apr 15 ;12(4). Epub 2020 Apr 15. PMID: 32326583 Abstract Title:  Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma. Abstract:  Patients with glioblastoma are at high risk of local recurrences after initial treatment with standard therapy, and recurrent tumor cells appear to be …

Continue reading “Betulinic acid-mediated tuning of PERK/CHOP signalling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma.”

PMID:  Mol Nutr Food Res. 2020 Apr 6:e1901315. Epub 2020 Apr 6. PMID: 32250024 Abstract Title:  Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress-Induced Intestinal Environment Imbalance and Lipopolysaccharide-Induced Liver Injury in HFD-Fed Rats by Regulating the Nrf2/HO-1/NQO1 and MAPK Pathways. Abstract:  SCOPE: This study investigates the modulatory effects of Lonicera caerulea L. polyphenols (LCPs) on …

Continue reading “Lonicera caerulea L. polyphenols alleviate oxidative stress-induced intestinal environment imbalance and lipopolysaccharide-induced liver injury.”