Author Archives: Taylor Mercado

PMID:  Andrologia. 2020 May ;52(4):e13554. Epub 2020 Mar 6. PMID: 32141651 Abstract Title:  Lycium barbarum polysaccharide protects against ethanol-induced spermiotoxicity and testicular degeneration in Immp2lmice. Abstract:  Studies have indicated that high levels of ethanol exposure impaired spermatogenesis in mice. However, the effects of chronic and low-dose alcohol consumption on susceptible populations remain unclear. The previous …

Continue reading “Lycium barbarum polysaccharide protects against ethanol-induced spermiotoxicity and testicular degeneration in Immp2l+/- mice.”

PMID:  J Pharm Biomed Anal. 2020 Feb 29 ;185:113219. Epub 2020 Feb 29. PMID: 32145536 Abstract Title:  Effects of extraction methods on immunology activity and chemical profiles of Lycium barbarum polysaccharides. Abstract:  It has been proven that polysaccharides have bioactivities and are beneficial to cure many diseases. Lycium barbarum fruit is widely used as a …

Continue reading “Effects of extraction methods on immunology activity and chemical profiles of Lycium barbarum polysaccharides.”

PMID:  Molecules. 2020 Mar 16 ;25(6). Epub 2020 Mar 16. PMID: 32188121 Abstract Title:  Immunomodulatory Effects ofPolysaccharide Extract and Its Uptake Behaviors at the Cellular Level. Abstract:  L. is a widely used functional food and medicinal herb in Asian countries.polysaccharides (LBP) are considered as one of the major medicinal components offruit and exhibits a wide …

Continue reading “These results demonstrate the immunomodulatory effects of L. barbarium polysaccharides and its effective uptake by macrophages and intestine.”

PMID:  J Food Biochem. 2020 Mar 26:e13215. Epub 2020 Mar 26. PMID: 32215941 Abstract Title:  Immunostimulating activity of Lycium chinense Miller root extract through enhancing cytokine and chemokine production and phagocytic capacity of macrophages. Abstract:  Whereas the fruits and a small portion of root bark of Lycium trees are commonly marketed in Korea as traditional …

Continue reading “Immunostimulating activity of Lycium chinense Miller root extract through enhancing cytokine and chemokine production and phagocytic capacity of macrophages.”

PMID:  Food Funct. 2020 Apr 30 ;11(4):3741-3748. PMID: 32314770 Abstract Title:  Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells. Abstract:  Impairment of the intestinal barrier often occurs in inflammatory bowel diseases, and pro-inflammatory factors play a vital role in the pathogenesis of intestinal diseases. In our …

Continue reading “Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells.”

PMID:  Front Endocrinol (Lausanne). 2020 ;11:164. Epub 2020 Apr 17. PMID: 32362869 Abstract Title:  Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats. Abstract:  The objective of this study was to investigate the protective effects ofpolysaccharides (LBP) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats. Compared to the control group, blood glucose levels were …

Continue reading “Lycium barbarum polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats.”

PMID:  Sci Rep. 2019 02 19 ;9(1):2301. Epub 2019 Feb 19. PMID: 30783194 Abstract Title:  Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expression. Abstract:  Autoimmune uveitis is a sight-threatening disease mainly caused by dysregulation of immunity. We investigated the …

Continue reading “Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation.”

PMID:  J Inflamm Res. 2019 ;12:231-239. Epub 2019 Aug 29. PMID: 31695470 Abstract Title:  Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. Abstract:  Background: Polyphenol catechins from green tea, particularly (-)-epigallocatechin-3-gallate (EGCG), exhibits numerous beneficial health effects, although the mechanisms remain unclear.Methods: In this study, the mechanism of …

Continue reading “Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators”

PMID:  Nutrients. 2020 Apr 10 ;12(4). Epub 2020 Apr 10. PMID: 32290071 Abstract Title:  Green Tea Polyphenol EGCG Attenuates MDSCs-mediated Immunosuppression through Canonical and Non-Canonical Pathways in a 4T1 Murine Breast Cancer Model. Abstract:  Several studies in the past decades have reported anti-tumor activity of the bioactive compounds extracted from tea leaves, with a focus …

Continue reading “These results provide new insight into the mechanism of EGCG-associated key pathways/genes in MDSCs in the murine breast tumor model.”

PMID:  Am J Respir Cell Mol Biol. 2020 May 6. Epub 2020 May 6. PMID: 32374624 Abstract Title:  Novel Therapy of Bicarbonate, Glutathione and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport. Abstract:  Defective airway mucus clearance is a defining characteristic of CF lung disease, and improvements to current mucolytic strategies are needed. Novel approaches targeting …

Continue reading “Novel therapy of bicarbonate, glutathione and ascorbic acid improves cystic fibrosis mucus transport.”