PMID: Cancer Res. 2019 Dec 15 ;79(24):6079-6083. Epub 2019 Oct 28. PMID: 31658978 Abstract Title: E-Cigarettes: Unstandardized, Under-Regulated, Understudied, and Unknown Health and Cancer Risks. Abstract: E-cigarettes have the ability to deliver nicotine in a manner that is similar to, and, theoretically, safer than, combusted tobacco. However, these devices are extremely heterogeneous and regulation has …
Author Archives: Taylor Mercado
Unusual cadinane-type sesquiterpene glycosides with α-glucosidase inhibitory activities from the fruit of Cornus officinalis.
PMID: Bioorg Chem. 2019 02 ;82:1-5. Epub 2018 Sep 20. PMID: 30267969 Abstract Title: Unusual cadinane-type sesquiterpene glycosides withα-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc. Abstract: Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E (1-5) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. …
New iridoid derivatives from the fruits of Cornus officinalis and their neuroprotective activities.
PMID: Molecules. 2019 Feb 11 ;24(3). Epub 2019 Feb 11. PMID: 30754635 Abstract Title: New Iridoid Derivatives from the Fruits ofand Their Neuroprotective Activities. Abstract: Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet …
Compositional analysis and biological characterization of Cornus officinalis on human 1.1B4 pancreatic β cells.
PMID: Mol Cell Endocrinol. 2019 08 20 ;494:110491. Epub 2019 Jun 27. PMID: 31255730 Abstract Title: Compositional analysis and biological characterization of Cornus officinalis on human 1.1B4 pancreaticβ cells. Abstract: Type 1 diabetes (T1D) is an autoimmune disease resulting from the loss of pancreaticβ cells and subsequent insulin production. Novel interventional therapies are urgently needed …
Neuroprotective effects of Cornus officinalis on stress-induced hippocampal deficits.
PMID: Antioxidants (Basel). 2019 Dec 26 ;9(1). Epub 2019 Dec 26. PMID: 31888114 Abstract Title: Neuroprotective Effects ofon Stress-Induced Hippocampal Deficits in Rats and HO-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Abstract: Oxidative stress plays a vital role in neurodegenerative diseases.(CC) has a wide range of pharmacological activities (e.g., antioxidant, neuroprotective, and anti-inflammatory). The present study …
Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple-negative breast cancer.
PMID: Oncol Lett. 2019 Jun ;17(6):5261-5266. Epub 2019 Mar 21. PMID: 31186742 Abstract Title: Growth inhibitory efficacy ofin a cell culture model for triple-negative breast cancer. Abstract: Triple-negative breast cancer (TNBC) lacks the expressions of estrogen receptor-α, progesterone receptor and human epidermal growth factor receptor-2. The treatment options for TNBC include anthracyclin/taxol based conventional chemotherapy …
Comparative study of crude and wine-processing Corni Fructus on chemical composition and antidiabetic effects.
PMID: Evid Based Complement Alternat Med. 2019 ;2019:3986964. Epub 2019 Dec 2. PMID: 31885645 Abstract Title: Comparative Study of Crude and Wine-Processingon Chemical Composition and Antidiabetic Effects. Abstract: Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects …
No animal models have been adequately standardized and validated to predict the risk of allergy and autoimmunity associated with vaccines.
PMID: Toxicology. 2002 May 15 ;174(1):45-51. PMID: 11972991 Abstract Title: Vaccines: predicting the risk of allergy and autoimmunity. Abstract: The field of vaccines is markedly evolving with the introduction and development of many new concepts and formulations, as well as new indications. Based on the current clinical experience, vaccines can be considered safe in most …
Preliminary testing of cancer vaccines caused mice to develop vitiligo.
PMID: Cancer Res. 2004 Feb 15 ;64(4):1509-14. PMID: 14973051 Abstract Title: Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin. Abstract: A major concern for cancer vaccines targeting self-tumor antigens is the risk of autoimmune sequelae. Although antitumor immunity correlates with autoimmune disease in some preclinical models, the mechanism(s) linking antitumor immunity …
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This review argues that vaccination does have autoimmune side effects and can even trigger a full-blown autoimmune disease.
PMID: Isr Med Assoc J. 2004 Jul ;6(7):430-2. PMID: 15274537 Abstract Title: Vaccination may be associated with autoimmune diseases. Abstract: [n/a] read more
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