PMID: Am J Physiol. 1991 Apr ;260(4 Pt 1):E537-43. PMID: 2018119 Abstract Title: Transferrin enhances the antiproliferative effect of aluminum on osteoblast-like cells. Abstract: Aluminum (Al) retention in the body can cause metabolic bone disease. This disorder is characterized by reductions in the number of osteoblasts, a feature that suggests a disturbance in bone cell …
Continue reading “Transferrin enhances the osteotoxic effects of aluminum.”
PMID: J Inorg Biochem. 2001 Nov ;87(1-2):9-14. PMID: 11709207 Abstract Title: Aluminium toxicity and iron homeostasis. Abstract: In an animal model of aluminum overload, (aluminium gluconate), the increases in tissue aluminium content were paralleled by elevations of tissue iron in the kidney, liver heart and spleen as well as in various brain regions, frontal, temporal …
PMID: Biochem J. 1990 Dec 1 ;272(2):377-82. PMID: 2268267 Abstract Title: Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia K562 cells. Abstract: Incubation of human erythroleukaemia K562 cells with Al-transferrin inhibited iron uptake from 59Fe-transferrin by about 80%. The inhibition was greater than that produced by a similar quantity of Fe-transferrin. …
PMID: J Biochem. 1998 Jan ;123(1):42-6. PMID: 9504407 Abstract Title: Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells. Abstract: We previously demonstrated that cultured human fibroblasts internalize iron via transferrin-independent iron uptake (Tf-IU), redox, and receptor-mediated endocytosis uptake systems [Oshiro, S., Nakajima, H., Markello, T., Krasnewich, D., Bernardini, …
Continue reading “Aluminum accumulates in the brain and affects iron metabolism.”
PMID: Cell Immunol. 2016 Jun-Jul;304-305:35-43. Epub 2016 May 14. PMID: 27212461 Abstract Title: Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood. Abstract: The recent increase in cases of whooping cough among teenagers in the US suggests that the acellular Bordetella pertussis vaccine (aP) …
PMID: J Agric Food Chem. 2018 Dec 19 ;66(50):13173-13182. Epub 2018 Dec 5. PMID: 30474364 Abstract Title: The Dose-Response Effect of Lycopene on Cerebral Vessel and Neuron Impairment Induced by Hyperlipidemia. Abstract: To study the dose-response effect of lycopene on vessel and neuron damage in the brain against hyperlipidemia, rats were fed with hypercholesterolemic feed …
PMID: Adv Nutr. 2019 01 1 ;10(1):19-29. PMID: 30475939 Abstract Title: Lycopene and Metabolic Syndrome: A Systematic Review of the Literature. Abstract: Cardiometabolic risk factors increase the likelihood of cardiovascular disease development by 2-fold. Lycopene, a potent lipophilic antioxidant, may be able to mediate oxidative stress, a mechanism underpinning metabolic syndrome (MetS) and its risk …
PMID: Int J Obes (Lond). 2019 09 ;43(9):1735-1746. Epub 2018 Dec 11. PMID: 30538283 Abstract Title: Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis. Abstract: BACKGROUND/OBJECTIVES: The aim of the current study was to investigate the inhibitory effect of lycopene (LYC), a major carotenoid present in tomato, …
PMID: Biomed Pharmacother. 2019 Jan ;109:2070-2077. Epub 2018 Nov 26. PMID: 30551463 Abstract Title: Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats. Abstract: Diabetes is a series of metabolic diseases, which characteristics is hyperglycemia caused by the interruption of insulin action. Lycopene is an antioxidant which has potential anti-diabetic activity but …
Continue reading “Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats.”
PMID: Biomed Pharmacother. 2019 Mar ;111:791-801. Epub 2019 Jan 4. PMID: 30616078 Abstract Title: A review for the pharmacological effect of lycopene in central nervous system disorders. Abstract: Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes, papayas, and watermelons. Previous studies have shown that lycopene can exert prophylactic and/or therapeutic effects in …
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