PMID: In Vivo. 2020 Mar-Apr;34(2):631-638. PMID: 32111763 Abstract Title: Astragaloside IV Induces Apoptosis, G-Phase Arrest and Inhibits Anti-apoptotic Signaling in Hepatocellular Carcinoma. Abstract: BACKGROUND/AIM: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and the third leading cause of cancer death worldwide. Although multiple chemotherapies options are available for HCC, chemo-induced toxicity is inevitable …
Author Archives: Taylor Mercado
Astragaloside IV may be a potential candidate agent for treating glioma andother central nervous system tumors.
PMID: Biosci Biotechnol Biochem. 2020 Mar 10:1-8. Epub 2020 Mar 10. PMID: 32154763 Abstract Title: Astragaloside IV suppresses transforming growth factor-β1-induced epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in glioma U251 cells. Abstract: Astragaloside IV (AS#IV) has previously demonstrated antitumoractivity. We investigated the effect and mechanisms of AS#IV in relation to epithelial-mesenchymal transition (EMT), viainterference …
Astragaloside -IV prevents dopaminergic neurodegeneration in Parkinson’s disease.
PMID: J Neuroinflammation. 2020 Apr 6 ;17(1):105. Epub 2020 Apr 6. PMID: 32252767 Abstract Title: Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease. Abstract: BACKGROUND: Senescent astrocytes have been implicated in the aging brain and neurodegenerative disorders, including Parkinson's disease (PD). Astragaloside IV (AS-IV) is an antioxidant derivative from a traditional Chinese herbal medicine …
Continue reading “Astragaloside -IV prevents dopaminergic neurodegeneration in Parkinson’s disease.”
Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.
PMID: Eur J Pharm Sci. 2020 May 30 ;148:105325. Epub 2020 Apr 4. PMID: 32259679 Abstract Title: Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2. Abstract: Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased …
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.
PMID: Cell Biochem Funct. 2020 Apr 19. Epub 2020 Apr 19. PMID: 32306464 Abstract Title: Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Cahomeostasis. Abstract: Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can …
Astragaloside IV stimulates hippocampal neurogenesis after stroke.
PMID: Front Pharmacol. 2020 ;11:421. Epub 2020 Apr 3. PMID: 32317974 Abstract Title: Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 ExpressionWnt Pathway. Abstract: Background: Stroke remains a leading cause of adult disability and the demand for stroke rehabilitation services is growing, and Astragaloside IV (As IV), a …
Continue reading “Astragaloside IV stimulates hippocampal neurogenesis after stroke.”
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.
PMID: Pharmacol Res. 2020 Apr 24:104831. Epub 2020 Apr 24. PMID: 32339782 Abstract Title: Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy. Abstract: Diabetic nephropathy (DN), a common complication of diabetes mellitus, is the main cause of end-stage nephropathy, and thus developing novel strategies for reversing DN remains urgent. Astragaloside IV (AS-IV), …
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
PMID: J Extracell Vesicles. 2020 ;9(1):1716513. Epub 2020 Jan 22. PMID: 32082513 Abstract Title: Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles. Abstract: Hepatitis A virus (HAV), a classic nonenveloped virus, has recently been found to be released mainly in the form …
Serum exosomal transfer of miR-483-3p might be involved in the inflammatory pathogenesis of H5N1 influenza virus infection.
PMID: Front Microbiol. 2020 ;11:144. Epub 2020 Feb 11. PMID: 32117163 Abstract Title: High Levels of miR-483-3p Are Present in Serum Exosomes Upon Infection of Mice With Highly Pathogenic Avian Influenza Virus. Abstract: Exosomes, the extracellular vesicles that contain functional proteins and RNAs, regulate cell-cell communication. Recently, our group reported that levels of various microRNAs …
Mycobacterium tuberculosis reactivates HIV-1 via exosome-mediated resetting of cellular redox potential and bioenergetics.
PMID: mBio. 2020 Mar 3 ;11(2). Epub 2020 Mar 3. PMID: 32127457 Abstract Title: Mycobacterium tuberculosis Reactivates HIV-1 via Exosome-Mediated Resetting of Cellular Redox Potential and Bioenergetics. Abstract: The synergy betweenand human immunodeficiency virus-1 (HIV-1) interferes with therapy and facilitates the pathogenesis of both human pathogens. Fundamental mechanisms by whichexacerbates HIV-1 infection are not clear. …
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