PMID: Cancer Manag Res. 2020 ;12:1713-1723. Epub 2020 Mar 9. PMID: 32210612 Abstract Title: Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways. Abstract: Purpose: Fucoidan is a natural bioactive product with broad therapeutic applications. Hepatocellular carcinoma (HCC) is a common malignancy of the liver associated with …
Author Archives: Taylor Mercado
Six Natural Substances to Alleviate Periodontal Disease
Studies have shown that natural compounds such as green tea and kiwi fruit can help alleviate the symptoms of periodontal and gum disease
Fucoidan induces apoptosis of HT-29 cells.
PMID: Mar Drugs. 2020 Apr 20 ;18(4). Epub 2020 Apr 20. PMID: 32326052 Abstract Title: Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway. Abstract: Fucoidan has a variety of pharmacological activities, but the understanding of the mechanism of fucoidan-induced apoptosis of colorectal cancer cells remains limited. The results of …
Continue reading “Fucoidan induces apoptosis of HT-29 cells.”
Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer.
PMID: Mol Med. 2020 Apr 8 ;26(1):28. Epub 2020 Apr 8. PMID: 32268876 Abstract Title: Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer. Abstract: BACKGROUND: The development of paclitaxel-resistance led to the tumor relapse and treatment failure of non-small cell lung cancer. Shikonin has been demonstrated to show anti-cancer …
Shikonin is a promising candidate for treatment of postmenopausal osteoporosis.
PMID: Biomed Pharmacother. 2020 Jun ;126:110067. Epub 2020 Apr 6. PMID: 32272431 Abstract Title: Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways. Abstract: BACKGROUND: Postmenopausal osteoporosis results from estrogen withdrawal and is characterized mainly by bone resorption. Shikonin is a bioactive constitute of Chinese traditional herb which plays a role in …
Continue reading “Shikonin is a promising candidate for treatment of postmenopausal osteoporosis.”
Shikonin could be a promising antioxidant candidate for age-associated neurodegenerative diseases.
PMID: Int Immunopharmacol. 2020 Apr 9 ;83:106491. Epub 2020 Apr 9. PMID: 32279045 Abstract Title: Shikonin ameliorates D-galactose-induced oxidative stress and cognitive impairment in mice via the MAPK and nuclear factor-κB signaling pathway. Abstract: Oxidative stress acts as the major causative factor for various age-associated neurodegenerative diseases, triggering cognitive and memory impairments. In the present …
Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells.
PMID: Anticancer Drugs. 2020 Apr 8. Epub 2020 Apr 8. PMID: 32282369 Abstract Title: Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the phosphatidylinositol 3 kinase/AKT signal pathway. Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor which is commonly found in East Asia and Africa. The present clinical treatment of NPC …
Shikonin attenuated a high fat diet-induced nonalcoholic fatty liver disease.
PMID: Nutrients. 2020 Apr 17 ;12(4). Epub 2020 Apr 17. PMID: 32316687 Abstract Title: Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation. Abstract: Shikonin, a natural plant pigment, is known to have anti-obesity activity and to improve insulin sensitivity. This study aimed to examine the effect of shikonin on …
Continue reading “Shikonin attenuated a high fat diet-induced nonalcoholic fatty liver disease.”
Benefits of Chlorogenic Acids Found in Coffee
Intake of coffee and other foods that contain chlorogenic acids has an inverse association with a number of chronic diseases
Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma.
PMID: J Asthma. 2017 May ;54(4):335-340. Epub 2016 Aug 15. PMID: 27715343 Abstract Title: Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma. Abstract: OBJECTIVES: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported …
Health Time 