Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults.

PMID:  Cureus. 2019 Dec 25 ;11(12):e6466. Epub 2019 Dec 25. PMID: 32021735 Abstract Title:  Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Abstract:  Background Stress, anxiety and impeded sleep are a frequent feature of life in modern societies. Across socio-economic strata, stress, anxiety and ineffective sleep …

Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer.

PMID:  J Ethnopharmacol. 2020 Jun 12 ;255:112759. Epub 2020 Mar 12. PMID: 32173425 Abstract Title:  Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (L.) Dunal (WS) is one of the moststudied Rasayana botanicals used in Ayurveda practice for its immunomodulatory, anti-aging, adaptogenic, and rejuvenating effects. The botanical is …

W. somnifera extract offers some potential advantages as a safe and effective adjunctive therapy to SSRIs in generalized anxiety disorder.

PMID:  Curr Clin Pharmacol. 2020 Apr 13. Epub 2020 Apr 13. PMID: 32282308 Abstract Title:  Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Abstract:  BACKGROUND: Anxiety disorders are the most universal psychiatric problems in the general population. Due to their chronic nature, these diseases are …

Ashwagandha supplementation might improve the VO2max in athlete and non-athlete people.

PMID:  Nutrients. 2020 Apr 17 ;12(4). Epub 2020 Apr 17. PMID: 32316411 Abstract Title:  Effects of Ashwagandha () on VO: A Systematic Review and Meta-Analysis. Abstract:  The purpose of this study was to systematically review the scientific literature about the effects of supplementation with Ashwagandha () on maximum oxygen consumption (VO), as well as to …

Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation.

PMID:  Int J Physiol Pathophysiol Pharmacol. 2018 ;10(2):70-82. Epub 2018 Apr 20. PMID: 29755640 Abstract Title:  Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation. Abstract:  Aging is associated with several biological, physiological, cellular and histological changes. In the present study, we investigated the effect of aging on different signaling …

Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice.

PMID:  Food Nutr Res. 2020 ;64. Epub 2020 Feb 4. PMID: 32110174 Abstract Title:  Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice. Abstract:  Background: Recent evidence indicates that the inhibition of hepatocyte apoptosis is possible to develop a potential therapeutic strategy for nonalcoholic fatty liver disease (NAFLD). Our previous …

Immunomodulatory activity of curcumin-entrapped poly d,l-lactic-co-glycolic acid nanoparticles in mice.

PMID:  Integr Med Res. 2018 Jun ;7(2):168-175. Epub 2018 Feb 20. PMID: 29989030 Abstract Title:  Immunomodulatory activity of curcumin-entrapped poly d,l-lactic–glycolic acid nanoparticles in mice. Abstract:  Background: Studies have shown that curcumin fromhas a wide range of medicinal and immunomodulatory properties. These activities have, however, been hindered by its low bioavailability. Meanwhile, incorporation of nanoparticles …

Melatonin treatment could be a novel therapeutic strategy for diabetic retinopathy.

PMID:  J Cell Physiol. 2020 Apr 23. Epub 2020 Apr 23. PMID: 32324260 Abstract Title:  Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. Abstract:  Diabetic retinopathy (DR) is the most common ocular complication caused by diabetes mellitus and is the main cause of visual impairment …

These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence.

PMID:  J Photochem Photobiol B. 2018 Sep ;186:69-80. Epub 2018 Jul 9. PMID: 30015062 Abstract Title:  Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways. Abstract:  The awareness of the interrelationship between immunosenescence and constant light exposure can provide new insights into the consequences …

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