PMID: Steroids. 2019 10 ;150:108447. Epub 2019 Jul 11. PMID: 31302113 Abstract Title: 24R,25-dihydroxyvitamin Dmodulates tumorigenicity in breast cancer in an estrogen receptor-dependent manner. Abstract: Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D], …
Author Archives: Taylor Mercado
Biologically active 1,25-dihydroxyvitamin D3 protects against experimental sepsis.
PMID: Int J Mol Med. 2019 Sep ;44(3):1151-1160. Epub 2019 Jul 5. PMID: 31524226 Abstract Title: Biologically active 1,25-dihydroxyvitamin D3 protects against experimental sepsis by negatively regulating the Toll-like receptor 4/myeloid differentiation primary response gene 88/Toll-IL-1 resistance Abstract: The hormonally active form of vitamin D (VD), 1,25‑dihydroxyvitamin D3, has been reported to be a key …
These results demonstrated that 1,25(OH)2D3 may enhance adriamycin-induced apoptosis.
PMID: Mol Med Rep. 2019 Sep ;20(3):2641-2648. Epub 2019 Jul 25. PMID: 31524258 Abstract Title: 1,25‑Dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species. Abstract: Anaplastic thyroid cancer (ATC) is a very aggressive malignancy that is resistant to various types of chemotherapy in …
The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)2D3
PMID: J Neuroimmunol. 2020 Jan 15 ;338:577079. Epub 2019 Oct 31. PMID: 31731230 Abstract Title: The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)D. Abstract: Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role …
1α, 25 Dihydroxyvitamin D (1,25(OH)2D) inhibits the T cell suppressive function of myeloid derived suppressor cells (MDSC).
PMID: J Steroid Biochem Mol Biol. 2020 Apr ;198:105557. Epub 2019 Nov 26. PMID: 31783150 Abstract Title: 1α, 25 Dihydroxyvitamin D (1,25(OH)D) inhibits the T cell suppressive function of myeloid derived suppressor cells (MDSC). Abstract: Myeloid derived suppressor cells (MDSC) suppress the ability of cytotoxic T cells to attack and clear tumor cells from the …
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
PMID: Aging Cell. 2020 02 ;19(2):e13095. Epub 2019 Dec 26. PMID: 31880094 Abstract Title: 1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. Abstract: To determine whether 1,25-dihydroxyvitamin D (1,25(OH)D) can exert an anti-osteoporosis role through anti-aging mechanisms, we analyzed the bone phenotype of mice with 1,25(OH)D deficiency due to deletion of …
1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence.
PMID: Am J Transl Res. 2020 ;12(2):507-518. Epub 2020 Feb 15. PMID: 32194899 Abstract Title: 1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence. Abstract: We investigated the role of insufficiency of the active form of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)D] in age-related bone loss. We employed mice with heterozygous …
Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation
PMID: Sci Rep. 2020 Apr 16 ;10(1):6550. Epub 2020 Apr 16. PMID: 32300237 Abstract Title: Vitamin C supports conversion of humanγδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation. Abstract: Humanγδ T cells are potent cytotoxic effector cells, produce a variety of cytokines, and can acquire regulatory activity. Induction of FOXP3, the key transcription …
NAC has a therapeutic effect on hepatotoxicity in children being treated with chemotherapeutic agents.
PMID: Ir J Med Sci. 2020 Apr 1. Epub 2020 Apr 1. PMID: 32239424 Abstract Title: Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury. Abstract: BACKGROUND: N-acetylcysteine (NAC) may be useful in the management of chemotherapy-induced liver injury.AIMS: The present study evaluates the possible therapeutic effects of NAC on chemotherapy-induced hepatotoxicity.METHODS: A total of 102 …
Safranal alleviates dextran sulfate sodium-induced colitis and suppresses macrophage-mediated inflammation.
PMID: Front Pharmacol. 2019 ;10:1281. Epub 2019 Nov 1. PMID: 31736758 Abstract Title: Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Abstract: (saffron) is widely used in China, Iran, and India for dyeing and as a food additive and medicinal plant. Safranal, as one of the main constituents of saffron, is responsible for …
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