PMID: J Nerv Ment Dis. 2020 Apr ;208(4):269-276. PMID: 32221179 Abstract Title: Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis. Abstract: BACKGROUND: Herbal remedies are becoming increasingly popular for the treatment of depression. Recently, accumulating evidences reveal a positive effect of saffron (Crocus sativus …
Author Archives: Taylor Mercado
Safranal is thought to be used as an effective combination in controlling metabolic complications caused by olanzapine.
PMID: Iran J Basic Med Sci. 2019 Dec ;22(12):1476-1482. PMID: 32133067 Abstract Title: Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic) induced metabolic disorders in rat. Abstract: Objectives: Olanzapine, an atypical antipsychotic, causes weight gain and metabolic disorders in humans. Safranal, one of the active components of(saffron), has been shown to …
N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism.
PMID: Nutr Neurosci. 2020 Apr 7:1-15. Epub 2020 Apr 7. PMID: 32264788 Abstract Title: N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism in adult male rats. Abstract: Hyperthyroidism is associated with impairment in the neurotransmission and severe tissue damage in the brain. The present study explored the potential deleterious effects of experimentally-induced hyperthyroidism …
Suppression effect of N-acetylcysteine on bone loss in ovariectomized mice.
PMID: Am J Transl Res. 2020 ;12(3):731-742. Epub 2020 Mar 15. PMID: 32269708 Abstract Title: Suppression effect of N-acetylcysteine on bone loss in ovariectomized mice. Abstract: Oxidative stress can trigger DNA damage response and activation of cellular senescence. Accumulating studies have demonstrated that senescent cells can produce senescence-associated secretory phenotype that leads to increased bone …
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Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling.
PMID: BMC Mol Cell Biol. 2020 Mar 27 ;21(1):20. Epub 2020 Mar 27. PMID: 32220226 Abstract Title: Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling. Abstract: BACKGROUND: Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a …
Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells.
PMID: Biosci Rep. 2020 Apr 30 ;40(4). PMID: 32232409 Abstract Title: Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway. Abstract: Cervical cancer is the fourth most common cancer in women globally. Lack of effective pharmacotherapies for cervical cancer mainly attributed to an elusive understanding of the …
Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer.
PMID: Oncol Rep. 2020 Feb 12. Epub 2020 Feb 12. PMID: 32323837 Abstract Title: Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer. Abstract: Tumor angiogenesis is an important factor which precipitates recurrence and metastasis of colorectal cancer (CRC). Angiogenesis is also a significant feature which accompanies invasion and metastasis …
Tanshinone IIA protects against acute pancreatitis in mice by inhibiting oxidative stress via the Nrf2/ROS pathway.
PMID: Oxid Med Cell Longev. 2020 ;2020:5390482. Epub 2020 Apr 8. PMID: 32322336 Abstract Title: Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway. Abstract: Background: Danshen (Bunge) and its main active component Tanshinone IIA (TSA) are clinically used in China. However, the effects of TSA on acute …
Combined antioxidant therapy with N-acetylcysteine reduces headaches and migraines in adult migraineurs.
PMID: Pain Pract. 2020 Apr 19. Epub 2020 Apr 19. PMID: 32306462 Abstract Title: Reduction in Migraine and Headache Frequency and Intensity with Combined Antioxidant Prophylaxis (N-acetylcysteine, Vitamin E and Vitamin C: NEC): A Randomized Sham-Controlled Pilot Study. Abstract: OBJECTIVE: To investigate the preventive effects of a combined antioxidant drug known as NEC (N-acetylcysteine, Vitamin …
PHLPP2 is a novel biomarker and epigenetic target for the treatment of vitamin C in pancreatic cancer.
PMID: Int J Oncol. 2020 Feb 25. Epub 2020 Feb 25. PMID: 32319585 Abstract Title: PHLPP2 is a novel biomarker and epigenetic target for the treatment of vitamin C in pancreatic cancer. Abstract: Epigenetic dysregulations are closely associated with the development of pancreatic ductal adenocarcinoma (PDAC), which is one of the most aggressive malignancies and …
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