Depressed levels of glutathione peroxidase are observed in patients with various skin disorders which are restored by selenium and vitamin E treatment.

PMID:  Acta Derm Venereol. 1982 ;62(3):211-4. PMID: 6179360 Abstract Title:  Blood glutathione-peroxidase levels in skin diseases: effect of selenium and vitamin E treatment. Abstract:  Blood glutathione-peroxidase (GSH-Px) was determined in 61 healthy subjects and 506 patients with various skin disorders. Depressed levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and …

The results of the current study indicate that isotretinoin treatment induces oxidative stress and liver damage by decreasing plasma vitamin E and increasing erythrocytes GSH-Px, GSH and liver enzyme values.

PMID:  Cell Biochem Funct. 2012 Oct ;30(7):552-7. Epub 2012 Apr 20. PMID: 22517509 Abstract Title:  Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Abstract:  Acne vulgaris is the one of the most common skin diseases. Although isotretinoin (13-cis-retinoic acid) is an effective and well-tolerated medication, it has …

A twice daily regimen of lactoferrin with vitamin E and zinc significantly reduced acne lesions in people with mild to moderate acne vulgaris.

PMID:  Int J Dermatol. 2017 Jun ;56(6):686-690. Epub 2017 Mar 30. PMID: 28369875 Abstract Title:  A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Abstract:  Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and …

Yarrow inhibits melanin production, suggesting it may be beneficial for hyperpigmentation disorders.

PMID:  PLoS One. 2014 ;9(4):e95186. Epub 2014 Apr 17. PMID: 24743745 Abstract Title:  The melanogenesis alteration effects of Achillea millefolium L. essential oil and linalyl acetate: involvement of oxidative stress and the JNK and ERK signaling pathways in melanoma cells. Abstract:  The mitogen-activated protein kinase (MAPK) family, including extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase …

This paper discusses the bioactivity of medicinal plant extracts and their use as wound closure inducing agents.

PMID:  Int J Toxicol. 2016 11 ;35(3 suppl):5S-15S. PMID: 27913788 Abstract Title:  Safety Assessment of Achillea millefolium as Used in Cosmetics. Abstract:  Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents-miscellaneous, skin-conditioning agents-humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their …

This study demonstrates that yarrow increases the proliferation and stimulation of dermal fibroblasts, suggesting it may have wound healing properties.

PMID:  Med Arch. 2015 Aug ;69(4):212-7. Epub 2015 Aug 4. PMID: 26543303 Abstract Title:  In Vitro Evaluation of Achillea Millefolium on the Production and Stimulation of Human Skin Fibroblast Cells (HFS-PI-16). Abstract:  AIM: In the present study, we aimed the effects of the hydroalcoholic extract of Achillea millefolium (HEAML) on human skin fibroblast cells (HSF-PI-16) …

Yarrow promotes skin resurfacing and improves the appearance of wrinkles and pores.

PMID:  Int J Cosmet Sci. 2011 Dec ;33(6):535-42. Epub 2011 Jun 29. PMID: 21711463 Abstract Title:  Surface rejuvenating effect of Achillea millefolium extract. Abstract:  Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides including adrenocorticotrophic hormone (ACTH) andβ-endorphin. POMC-derived peptides have been shown to be synthesized in human epidermis where they modulate numerous …

Yarrow demonstrated significant anti-inflammatory activity when applied topically.

PMID:  J Ethnopharmacol. 2017 Mar 6 ;199:138-148. Epub 2017 Feb 3. PMID: 28163113 Abstract Title:  The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in …

The complex role of vitamin D in autoimmune diseases.

PMID:  Scand J Immunol. 2008 Sep ;68(3):261-9. Epub 2008 May 29. PMID: 18510590 Abstract Title:  The complex role of vitamin D in autoimmune diseases. Abstract:  Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin …

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms.

PMID:  Pulm Pharmacol Ther. 2015 Jun ;32:60-74. Epub 2015 Feb 28. PMID: 25732539 Abstract Title:  Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Abstract:  Vitamin D deficiency (VDD) is highly prevalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and …

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