PMID: Proc Natl Acad Sci U S A. 2003 Jun 10 ;100(12):7360-5. Epub 2003 May 27. PMID: 12771381 Abstract Title: Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Abstract: Mice deficient in the epidermal water/glycerol transporter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and impaired barrier …
Author Archives: Taylor Mercado
Riboflavin deficiency impairs NADPH oxidase 2 priming and defense against Listeria monocytogenes.
PMID: Eur J Immunol. 2014 Mar ;44(3):728-41. Epub 2013 Dec 27. PMID: 24272050 Abstract Title: Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Abstract: Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which …
Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo.
PMID: J Invest Dermatol. 2003 May ;120(5):835-41. PMID: 12713590 Abstract Title: Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. Abstract: Human skin is exposed to solar ultraviolet radiation. Ultraviolet radiation damages human skin and results in an old and wrinkled appearance, called photoaging. We have previously …
Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-γ-mediated immune activation.
PMID: Br J Nutr. 2014 Oct 14 ;112(7):1065-72. Epub 2014 Aug 8. PMID: 25105221 Abstract Title: Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-γ-mediated immune activation in the community-based Hordaland Health Study. Abstract: Vitamins B2 and B6 are cofactors in the kynurenine pathway. Many of the kynurenines are neuroactive compounds …
Topical N-acetylcysteine accelerates wound healing in vitro and in vivo via the PKC/Stat3 pathway.
PMID: Int J Mol Sci. 2014 May 2 ;15(5):7563-78. Epub 2014 May 2. PMID: 24798751 Abstract Title: Topical N-acetylcysteine accelerates wound healing in vitro and in vivo via the PKC/Stat3 pathway. Abstract: N-Acetylcysteine (Nac) is an antioxidant administered in both oral and injectable forms. In this study, we used Nac topically to treat burn wounds …
N-acetylcysteine is as effective as dexpanthenol in wound healing.
PMID: Int Surg. 2015 Apr ;100(4):656-61. Epub 2015 Jan 13. PMID: 25583306 Abstract Title: Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Abstract: In this study, we aimed to compare the effects of dexpanthenol and N-acetylcysteine on wound healing. The wound healing process is a multifaceted sequence of activities associated with tissue …
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Antiproliferative effects of thymoquinone in MCF-7 breast and HepG2 liver cancer cells: possible role of ceramide and ER stress.
PMID: Nutr Cancer. 2020 Apr 14:1-13. Epub 2020 Apr 14. PMID: 32286088 Abstract Title: Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress. Abstract: We aimed to investigate the impact of thymoquinone (TQ), on sphingolipid metabolites, ER stress and apoptotic pathways in MCF-7 and HepG2 …
The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions.
PMID: J Clin Aesthet Dermatol. 2019 May ;12(5):20-26. Epub 2019 May 1. PMID: 31320973 Abstract Title: The Potential Uses of N-acetylcysteine in Dermatology: A Review. Abstract: In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions.The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders.The …
This review suggests that a novel seaweed oligosaccharide-zinc complex ameliorates the symptoms of acne.
PMID: J Cosmet Sci. 2013 May-Jun;64(3):219-26. PMID: 23752036 Abstract Title: A novel topical ingredient derived from seaweed significantly reduces symptoms of acne vulgaris: a general literature review. Abstract: Currently, benzoyl peroxide, antibiotics, and retinoids are the mainstay topical treatments for acne vulgaris. However, potential benefits may be offered by natural, marine-derived ingredients, such as those …
Effect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet’s disease.
PMID: Avicenna J Phytomed. 2020 Mar-Apr;10(2):181-189. PMID: 32257890 Abstract Title: Effect ofoil extracts on inflammatory and oxidative stress markers in Behcet's disease: A randomized, double-blind, placebo-controlled clinical trial. Abstract: Objective: Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Oxidative stress and inflammation have …
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