PMID: Nature. 2019 Sep ;573(7773):271-275. Epub 2019 Sep 4. PMID: 31485074 Abstract Title: Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Abstract: Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals. …
Author Archives: Taylor Mercado
Cucurbitacin B exerts antiaging effects in yeast by regulating autophagy and oxidative stress.
PMID: Oxid Med Cell Longev. 2019 ;2019:4517091. Epub 2019 Jun 2. PMID: 31281576 Abstract Title: Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress. Abstract: The budding yeasthas been used as a model organism for the basic mechanism of aging, which provides useful assay systems for measuring both replicative and chronological …
Ascorbic acid mitigates the deleterious effects of nicotine on tendon stem cells.
PMID: Connect Tissue Res. 2019 Sep 5:1-11. Epub 2019 Sep 5. PMID: 31488012 Abstract Title: Ascorbic acid mitigates the deleterious effects of nicotine on tendon stem cells. Abstract: : Nicotine causes tendon degeneration, whereas ascorbic acid imparts beneficial effects on tendon cells. Tendon stem cells (TSCs) play a vital role in maintaining tissue integrity and …
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High dose vitamin c may inhibit proliferation of breast cancer cells both in vitro and in vivo through reducing glycolysis and protein synthesis.
PMID: Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 May 25 ;48(3):296-302. PMID: 31496162 Abstract Title: [High dose vitamin C inhibits proliferation of breast cancer cells through reducing glycolysis and protein synthesis]. Abstract: OBJECTIVE: To investigate the effects of high dose vitamin C (VC) on proliferation of breast cancer cells and to explore its …
Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer.
PMID: Epigenetics. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31505989 Abstract Title: Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells. Abstract: Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) lead to metabolic alterations and a sustained formation of 2-hydroxyglutarate (2-HG). …
Late gadolinium enhancement in cardiac amyloidosis: attributable both to interstitial amyloid deposition and subendocardial fibrosis caused by ischemia.
PMID: Heart Vessels. 2016 Jun ;31(6):990-5. Epub 2015 Mar 21. PMID: 25794983 Abstract Title: Late gadolinium enhancement in cardiac amyloidosis: attributable both to interstitial amyloid deposition and subendocardial fibrosis caused by ischemia. Abstract: Gadolinium contrast agents used for late gadolinium enhancement (LGE) distribute in the extracellular space. Global diffuse myocardial LGE pronounced in the subendocardial …
Gadolinium deposition disease: Initial description of a disease that has been around for a while.
PMID: Magn Reson Imaging. 2016 Dec ;34(10):1383-1390. Epub 2016 Aug 13. PMID: 27530966 Abstract Title: Gadolinium deposition disease: Initial description of a disease that has been around for a while. Abstract: PURPOSE: To describe the clinical manifestations of presumed gadolinium toxicity in patients with normal renal function.MATERIALS AND METHODS: Participants were recruited from two online …
Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function.
PMID: Toxicol Lett. 2019 Feb ;301:157-167. Epub 2018 Nov 23. PMID: 30476537 Abstract Title: Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function exposed to Gd-based contrast agents. Abstract: Gadolinium deposition in tissue is linked to nephrogenic systemic fibrosis (NSF): a rare disorder occurring in patients with severe chronic kidney disease …
A structured survey on adverse events occurring within 24 hours after intravenous exposure to gadodiamide or gadoterate meglumine.
PMID: Invest Radiol. 2019 04 ;54(4):191-197. PMID: 30379729 Abstract Title: A Structured Survey on Adverse Events Occurring Within 24 Hours After Intravenous Exposure to Gadodiamide or Gadoterate Meglumine: A Controlled Prospective Comparison Study. Abstract: OBJECTIVE: This study compares the incidence of new-onset symptoms within 24 hours after enhanced magnetic resonance imaging (eMRI) with intravenous administration …
Cumulative gadodiamide administration leads to brain gadolinium deposition in early multiple sclerosis.
PMID: Neurology. 2019 Aug 6 ;93(6):e611-e623. Epub 2019 Jul 8. PMID: 31285398 Abstract Title: Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS. Abstract: OBJECTIVE: Frequent administration of gadolinium-based contrast agents in multiple sclerosis (MS) may increase signal intensity (SI) unenhanced T1-weighted imaging MRI throughout the brain. We evaluated the association between lifetime …
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