PMID: 

Mol Cell Probes. 2019 Aug ;46:101419. Epub 2019 Jul 4. PMID: 31279748

Abstract Title: 

Effects of lycopene on ovarian cancer cell line SKOV3 in vitro: Suppressed proliferation and enhanced apoptosis.

Abstract: 

AIMS: This study aims to investigate the influences of lycopene on ovarian cancer cells SKOV3 in vitro and the corresponding mechanism.METHODS: SKOV3 cultures were divided into four groups and treated with lycopene at 0 (the control group), 1 × 10, 1 × 10and 1 × 10 mol/L respectively. The proliferation rate of SKOV3 cells was determined using MTT colorimetric assay, and the apoptosis rate of SKOV3 cells was measured using flow cytometry. Western blotting was used to detect the expressions of Bax and Bcl-2.RESULTS: When compared with the control group, the proliferation rates of SKOV3 cells in the three lycopene groups were significantly lower (P 

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PMID: 

Int J Vitam Nutr Res. 2019 Jul 15:1-21. Epub 2019 Jul 15. PMID: 31303127

Abstract Title: 

Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice.

Abstract: 

The present study revealed the effects of Lycopene enriched tomato extract (LycT) on chemically induced skin cancer in mice. Skin tumors were induced by topical application of 7,12-Dimethylbenz(a)anthracene (DMBA) [500 nmol/100 ul of acetone, twice a week for two weeks] and 12-O-tetradecanoyl phorbol-13-acetate (TPA) [1.7 nmol/100 ul of acetone, twice a week for eighteen weeks] and LycT (5 mg/kg b.w.) was administered orally. Male Balb/c mice were divided into four groups (n = 15 per group): control, DMBA/TPA, LycT and LycT + DMBA/TPA. The chemopreventive response of LycT to skin tumorigenesis was evident by inhibition in tumor incidence, number, size, burden and volume in LycT + DMBA/TPA group when compared to DMBA/TPA group. This was associated with inhibition of cell proliferation in LycT + DMBA/TPA group as observed by the decrease in epidermal morphometric parameters and mRNA and protein expression of proliferating cell nuclear antigen when compared to DMBA/TPA group (p ≤ 0.05). LycT decreased (p ≤ 0.05) the mRNA and protein expression of angiogenic genes (vascular endothelial growth factor, angiopoietin-2, basic fibroblast growth factor) in LycT + DMBA/TPA group, suggesting its anti-angiogenic effects. The increase (p ≤ 0.05) in protein expression of connexin-32 and 43 in LycT + DMBA/TPA group suggests improved inter cellular communication when compared to DMBA/TPA group. Histochemical studies demonstrated that the components of extracellular matrix (fibrous proteins and mucopolysaccharides) were also modulated during skin carcinogenesis and its chemoprevention by LycT. The decrease in cell proliferation parameters and expression of angiogenesis associated genes, modulation of ECM components and increase in expression of connexins suggest that LycT improved multiple dysregulated processes during chemoprevention of skin cancer.

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PMID: 

Braz J Cardiovasc Surg. 2019 Jul 31. Epub 2019 Jul 31. PMID: 31364342

Abstract Title: 

Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats.

Abstract: 

OBJECTIVE: To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.METHODS: In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.RESULTS: Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P

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PMID: 

Antioxidants (Basel). 2019 Aug 5 ;8(8). Epub 2019 Aug 5. PMID: 31387231

Abstract Title: 

Lycopene Modulates Pathophysiological Processes of Non-Alcoholic Fatty Liver Disease in Obese Rats.

Abstract: 

: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on NAFLD related to the obesity induced by a hypercaloric diet.: Wistar rats were distributed in two groups: Control (Co,= 12) and hypercaloric (Ob,= 12). After 20 weeks, the animals were redistributed into the control group (Co,= 6), control group supplemented with lycopene (Co+Ly,= 6), obese group (Ob,= 6), and obese group supplemented with lycopene (Ob+Ly,= 6). Ob groups also received water + sucrose (25%). Animals received lycopene solution (10 mg/kg/day) or vehicle (corn oil) via gavage for 10 weeks.: Animals which consumed the hypercaloric diet had higher adiposity index, increased fasting blood glucose, hepatic and blood triglycerides, and also presented in the liver macro and microvesicular steatosis, besides elevated levels of tumor necrosis factor-α (TNF-α). Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-α, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity.: Lycopene shows therapeutic potential to NAFLD.

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PMID: 

Mol Nutr Food Res. 2019 Aug 13:e1900602. Epub 2019 Aug 13. PMID: 31408586

Abstract Title: 

Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages.

Abstract: 

SCOPE: Adipose tissue macrophage (ATM) recruitment and polarization are pivotal in the development of insulin resistance. However, treatment modalities targeting ATMs remain limited. We examined the effects of lycopene, an antioxidant carotenoid compound, on adipose tissue inflammation and insulin resistance in high fat (HF) diet-induced obese mice.METHODS AND RESULTS: C57BL/6J mice were fed a HF diet or a HF diet containing lycopene (HF+LY) for 8 weeks. Lycopene attenuated HF diet-induced glucose intolerance and hyperinsulinemia. Compared with HF mice, HF+LY mice exhibited attenuated adipocyte hypertrophy and macrophage infiltration in epididymal white adipose tissue (eWAT) and hepatic steatosis and inflammation. Flow cytometry analysis of ATMs demonstrated that lycopene attenuated the increased number of ATMs in HF diet-fed mice. In addition, HF+LY mice had 23% fewer M1-polarized ATMs and 60% more M2-polarized ATMs than HF mice, resulting in the predominance of M2 over M1 in the ATM population. M2-dominant polarization was also seen in hepatic macrophages in HF+LY mice. Moreover, lycopene promoted IL-4-induced M2 polarization by increasing the phosphorylation levels of STAT6 and Akt in Raw 264.7 macrophages.CONCLUSIONS: Lycopene facilitated M2-dominant polarization in ATM, thereby attenuating HF diet-induced inflammation and insulin resistance in eWAT and the liver. This article is protected by copyright. All rights reserved.

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PMID: 

Nutrients. 2019 Jul 12 ;11(7). Epub 2019 Jul 12. PMID: 31336992

Abstract Title: 

Honey Supplementation and Exercise: A Systematic Review.

Abstract: 

Honey is a natural substance formed primarily of carbohydrates (~80%) which also contains a number of other compounds purported to confer health benefits when consumed. Due to its carbohydrate composition (low glycaemic index, mostly fructose and glucose), honey may theoretically exert positive effects when consumed before, during or after exercise. This review therefore appraised research examining the effects of honey consumption in combination with exercise in humans. Online database (PubMed, MEDLINE, SPORTDiscus) searches were performed, yielding 273 results. Following duplicate removal and application of exclusion criteria, nine articles were reviewed. Large methodological differences existed in terms of exercise stimulus, population, and the nutritional interventions examined. All nine studies reported biochemical variables, with four examining the effects of honey on exercise performance, whilst five described perceptual responses. Acute supplementation around a single exercise session appeared to elicit similar performance, perceptual, and immunological responses compared with other carbohydrate sources, although some performance benefit has been observed relative to carbohydrate-free comparators. When consumed over a number of weeks, honey may dampen immunological perturbations arising from exercise and possibly improve markers of bone formation. More well-controlled research is required to better understand the role for honey in a food-first approach to exercise nutrition.

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PMID: 

Nutrients. 2019 Aug 9 ;11(8). Epub 2019 Aug 9. PMID: 31405041

Abstract Title: 

Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children.

Abstract: 

Research has investigated 25-hydroxyvitamin D (25(OH)D) levels in the Atopic Dermatitis (AD) population, as well as changes in AD severity after vitamin D (VitD) supplementation. We performed an up-to-date systematic review and meta-analysis of these findings. Electronic searches of MEDLINE, EMBASE and COCHRANE up to February 2018 were performed. Observational studies comparing 25(OH)D between AD patients and controls, as well as trials documenting baseline serum 25(OH)D levels and clinical severity by either SCORAD/EASI scores, were included. Of the 1085 articles retrieved, sixteen were included. A meta-analysis of eleven studies of AD patients vs. healthy controls (HC) found a mean difference of -14 nmol/L (95% CI -25 to -2) for all studies and -16 nmol/L (95% CI -31 to -1) for the paediatric studies alone. A meta-analysis of three VitD supplementation trials found lower SCORAD by -11 points (95% CI -13 to -9,

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PMID: 

BMJ. 2019 08 12 ;366:l4673. Epub 2019 Aug 12. PMID: 31405892

Abstract Title: 

Association between vitamin D supplementation and mortality: systematic review and meta-analysis.

Abstract: 

OBJECTIVE: To investigate whether vitamin D supplementation is associated with lower mortality in adults.DESIGN: Systematic review and meta-analysis of randomised controlled trials.DATA SOURCES: Medline, Embase, and the Cochrane Central Register from their inception to 26 December 2018.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials comparing vitamin D supplementation with a placebo or no treatment for mortality were included. Independent data extraction was conducted and study quality assessed. A meta-analysis was carried out by using fixed effects and random effects models to calculate risk ratio of death in the group receiving vitamin D supplementation and the control group.MAIN OUTCOME MEASURES: All cause mortality.RESULTS: 52 trials with a total of 75 454 participants were identified. Vitamin D supplementation was not associated with all cause mortality (risk ratio 0.98, 95% confidence interval 0.95 to 1.02, I=0%), cardiovascular mortality (0.98, 0.88 to 1.08, 0%), or non-cancer, non-cardiovascular mortality (1.05, 0.93 to 1.18, 0%). Vitamin D supplementation statistically significantly reduced the risk of cancer death (0.84, 0.74 to 0.95, 0%). In subgroup analyses, all cause mortality was significantly lower in trials with vitamin Dsupplementation than in trials with vitamin Dsupplementation (P for interaction=0.04); neither vitamin Dnor vitamin Dwas associated with a statistically significant reduction in all cause mortality.CONCLUSIONS: Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment. Vitamin D supplementation reduced the risk of cancer death by 16%. Additional large clinical studies are needed to determine whether vitamin Dsupplementation is associated with lower all cause mortality.STUDY REGISTRATION: PROSPERO registration number CRD42018117823.

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PMID: 

Nutr Rev. 2019 Aug 13. Epub 2019 Aug 13. PMID: 31407792

Abstract Title: 

Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis.

Abstract: 

CONTEXT: Vitamin D deficiency is highly prevalent across the world. The existing evidence suggests vitamin D may have beneficial effects on serum lipid profiles and thus cardiovascular health.OBJECTIVE: The objective of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on serum lipid profiles.DATA SOURCE: Original randomized controlled trials (RCTs) examining the effect of vitamin D supplementation on serum lipid profiles and published before July 2018 were identified by searching online databases, including PubMed, Google Scholar, and ScienceDirect, using a combination of relevant keywords.DATA EXTRACTION: Data on study characteristics, effect size, measure of variation, type of vitamin D supplementation, and duration of follow-up were extracted by the author.DATA ANALYSIS: PRISMA guidelines for systematic reviews were followed. Random effects (DerSimonian and Laird [D-V)] models were used to pool standardized mean differences in total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides between the active and the placebo arms of RCT studies. Between-study heterogeneities were assessed using Cochrane Q and I2, and publication bias was assessed using Begg's test, Egger's test, and funnel plot.RESULTS: A total of 41 RCTs comprising 3434 participants (n = 1699 in the vitamin D supplementation arm and n = 1735 in the placebo arm) were identified and included in the meta-analysis. Approximately 63.4% of study participants were women, with 14 studies conducted entirely among women. Approximately 24% of the trials had follow-up duration>6 months, whereas the remaining 76% had follow-up duration of

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PMID: 

Helicobacter. 2019 Aug 14:e12655. Epub 2019 Aug 14. PMID: 31411799

Abstract Title: 

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta-analysis.

Abstract: 

BACKGROUND: Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta-analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication.METHODS: Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English-language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1.RESULTS: Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori-positive patients was lower than H pylori-negative (SMD = -0.53 ng/mL, 95% CI = (-0.91, -0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta-analysis results were stable and reliable.CONCLUSIONS: Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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