PMID: 

Shanghai Kou Qiang Yi Xue. 2018 Dec ;27(6):633-636. PMID: 30899946

Abstract Title: 

[The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus].

Abstract: 

PURPOSE: To observe the curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus.METHODS: Fifty patients with severe periodontitis and diabetes mellitus were randomly divided into 2 groups. The patients in the control group were treated with scaling and root planning(SRP); while patients in the experimental group were treated with SRP followed by topical use of rhubarb extract. Periodontal index probing pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were examined before periodontal treatment，6 weeks and 12 weeks after treatment. SPSS 20.0 software package was used for statistical analysis.RESULTS: Significant improvement in periodontal condition was noted in both groups after treatment, and the degree of improvement was greater in the experimental group than in the control group. No adverse event during the entire study was found.CONCLUSIONS: Topical application of rhubarb extract for the treatment of severe periodontitis with diabetes has good clinical efficacy.

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PMID: 

Zhonghua Nan Ke Xue. 2003 Oct ;9(7):494-6, 500. PMID: 14628594

Abstract Title: 

[Evaluation of radiation damage to the sperm DNA of radar operators].

Abstract: 

OBJECTIVE: To evaluate the inflicted by radar electromagnetic radiation to the sperm DNA of radar operators.METHODS: Sperm concentration, viability, motility, sperm abnormality were determined by routine sperm analysis and sperm chromatin structure assay (SCSA) in the highly exposed group(n = 88), lowly exposed group(n = 143) and control group(n = 39).RESULTS: Sperm motility, viability of the highly exposed group reduced compared with that of the lowly exposed group and control group, while sperm abnormality increased. The COMP alpha reduction of the highly exposed group indicated that the highly exposed group had a medium fertility potential. The multifactor variable analysis showed that daily working time was a dangerous factor in sperm abnormality and abstinence time was a dangerous factor in the parameter of SCSA.CONCLUSIONS: Radar radiation inflicts damage to male reproduction system and it is important to take protective measures.

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PMID: 

BMJ. 2012 Mar 8 ;344:e1147. Epub 2012 Mar 8. PMID: 22403263

Abstract Title: 

Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States.

Abstract: 

OBJECTIVE: In view of mobile phone exposure being classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC), we determined the compatibility of two recent reports of glioma risk (forming the basis of the IARC's classification) with observed incidence trends in the United States.DESIGN: Comparison of observed rates with projected rates of glioma incidence for 1997-2008. We estimated projected rates by combining relative risks reported in the 2010 Interphone study and a 2011 Swedish study by Hardell and colleagues with rates adjusted for age, registry, and sex; data for mobile phone use; and various latency periods.SETTING: US population based data for glioma incidence in 1992-2008, from 12 registries in the Surveillance, Epidemiology, and End Results (SEER) programme (Atlanta, Detroit, Los Angeles, San Francisco, San Jose-Monterey, Seattle, rural Georgia, Connecticut, Hawaii, Iowa, New Mexico, and Utah).PARTICIPANTS: Data for 24,813 non-Hispanic white people diagnosed with glioma at age 18 years or older.RESULTS: Age specific incidence rates of glioma remained generally constant in 1992-2008 (-0.02% change per year, 95% confidence interval -0.28% to 0.25%), a period coinciding with a substantial increase in mobile phone use from close to 0% to almost 100% of the US population. If phone use was associated with glioma risk, we expected glioma incidence rates to be higher than those observed, even with a latency period of 10 years and low relative risks (1.5). Based on relative risks of glioma by tumour latency and cumulative hours of phone use in the Swedish study, predicted rates should have been at least 40% higher than observed rates in 2008. However, predicted glioma rates based on the small proportion of highly exposed people in the Interphone study could be consistent with the observed data. Results remained valid if we used either non-regular users or low users of mobile phones as the baseline category, and if we constrained relative risks to be more than 1.CONCLUSIONS: Raised risks of glioma with mobile phone use, as reported by one (Swedish) study forming the basis of the IARC's re-evaluation of mobile phone exposure, are not consistent with observed incidence trends in US population data, although the US data could be consistent with the modest excess risks in the Interphone study.

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PMID: 

Iran J Basic Med Sci. 2019 Mar ;22(3):328-333. PMID: 31156796

Abstract Title: 

Reno-protective effect ofagainst gentamicin-induced nephrotoxicity.

Abstract: 

Objectives: Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract ofwas used against gentamicin- induced nephrotoxicity and its effect against gentamicin-induced nephrotoxicity in rats has been investigated.Materials and Methods: The rats were placed into one of these groups: saline group, gentamicin group that received gentamicin 80 mg/kg/day for six days, and two treatment groups that receivedintraperitoneally at doses of 100 and 200 mg/kg body weight, respectively, 1 hr before gentamicin injections. Urine samples were collected at 24 hr to measure glucose and protein concentration. Blood samples were collected to determine serum urea and creatinine. One kidney was homogenized to measure malondialdehyde and thiol, and the other kidney was kept for pathological studies.Results: Gentamicin increased the level of urinary glucose and protein, and increased malondialdehyde while it decreased thiol in kidney tissue, and increased the concentration of urea and creatinine in the serum. Histopathological pathology revealed renal damage following gentamicin usage; however, the extract was able to improve gentamicin toxicity.Conclusion: has positive effects in the attenuation of gentamicin-induced nephrotoxicity.

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PMID: 

Am J Ind Med. 2001 May ;39(5):499-504. PMID: 11333411

Abstract Title: 

Pregnancy outcome following exposure to shortwaves among female physiotherapists in Israel.

Abstract: 

BACKGROUND: The findings of the few epidemiological studies on the possible association between shortwave diathermy use by pregnant physiotherapists and adverse pregnancy outcome are inconsistent. We investigated such an association among physiotherapists in Israel.METHODS: Individualized data on exposure to shortwaves, ultrasound, and heavy lifting were collected by questionnaires and telephone interviews.RESULTS: The 434 studied women included 930 pregnancies: 175 ended in spontaneous abortions, 45 had fetal malformations, 47 were delivered prematurely, and 33 infants had low birth weight. The remaining 630 normal pregnancies comprised the control group. Univariate analysis showed that exposure to shortwaves was associated with a significantly increased odds ratio (O.R.) for congenital malformations (O.R. 2.24, CI 1.27-4.83, P =.006) and low birth weight (O.R. 2.99, CI 1.32-6,79, P =.006). This effect increased in a dose-related manner. After controlling for potential confounding variables, only low birth weight reached statistical significance (O.R. 2.75, CI 1.07-7.04, P =.03). From the potentially confounding variables tested, febrile disease during pregnancy was found to be significantly associated with low birth weight (O.R. 3.37, CI 1.38-8.25, P =.01).CONCLUSIONS: The findings of our study suggest that shortwaves have potentially harmful effects on pregnancy outcome, specifically low birth weight.

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PMID: 

J Neurooncol. 2011 Feb ;101(3):505-7. Epub 2010 Jun 30. PMID: 20589524

Abstract Title: 

Association between number of cell phone contracts and brain tumor incidence in nineteen U.S. States.

Abstract: 

Some concern has arisen about adverse health effects of cell phones, especially the possibility that the low power microwave-frequency signal transmitted by the antennas on handsets might cause brain tumors or accelerate the growth of subclinical tumors. We analyzed data from the Statistical Report: Primary Brain Tumors in the United States, 2000-2004 and 2007 cell phone subscription data from the Governing State and Local Sourcebook. There was a significant correlation between number of cell phone subscriptions and brain tumors in nineteen US states (r = 0.950, P

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PMID: 

Bioelectromagnetics. 2011 Oct ;32(7):535-42. Epub 2011 Mar 15. PMID: 21412810

Abstract Title: 

Genotoxic effects of 3 T magnetic resonance imaging in cultured human lymphocytes.

Abstract: 

The clinical and preclinical use of high-field intensity (HF, 3 T and above) magnetic resonance imaging (MRI) scanners have significantly increased in the past few years. However, potential health risks are implied in the MRI and especially HF MRI environment due to high-static magnetic fields, fast gradient magnetic fields, and strong radiofrequency electromagnetic fields. In this study, the genotoxic potential of 3 T clinical MRI scans in cultured human lymphocytes in vitro was investigated by analyzing chromosome aberrations (CA), micronuclei (MN), and single-cell gel electrophoresis. Human lymphocytes were exposed to electromagnetic fields generated during MRI scanning (clinical routine brain examination protocols: three-channel head coil) for 22, 45, 67, and 89 min. We observed a significant increase in the frequency of single-strand DNA breaks following exposure to a 3 T MRI. In addition, the frequency of both CAs and MN in exposed cells increased in a time-dependent manner. The frequencies of MN in lymphocytes exposed to complex electromagnetic fields for 0, 22, 45, 67, and 89 min were 9.67, 11.67, 14.67, 18.00, and 20.33 per 1000 cells, respectively. Similarly, the frequencies of CAs in lymphocytes exposed for 0, 45, 67, and 89 min were 1.33, 2.33, 3.67, and 4.67 per 200 cells, respectively. These results suggest that exposure to 3 T MRI induces genotoxic effects in human lymphocytes.

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PMID: 

Pharmacology. 2019 Jul 23:1-11. Epub 2019 Jul 23. PMID: 31336368

Abstract Title: 

The Protective Effect of Aesculus hippocastanum (Venoplant®) Against Concanavalin A-Induced Liver Injury.

Abstract: 

AIM: The present study was performed to investigate the effect of Aesculus hippocastanum (AH; Venoplant®) on concanavalin A (ConA)-induced acute liver injury and explore the mechanism in mice.METHODS: ConA (20 mg/kg) was administered via tail vein injection to induce hepatic damage. The groups of AH (Venoplant®) were given at 65.8, 131.6, and 263.2 mg/kg by oral gavages for 20 days. The serum levels of aspartate transaminase (AST), alanine aminotransferase (ALT), total protein (TP), and albumin (Alb) were determined by automatic biochemical analyzer, and the Alb/globulin (A/G) ratio was calculated. Tumor necrosis factor-α (TNF-α) and IFN-γ levels were assayed by enzyme-linked immunosorbent assay. The liver tissue was attained by hematoxylin and eosin, and the histopathological changes were calculated. The cell apoptosis was assayed by terminal dUTP nick-end labeling. The malondialdehyde (MDA),superoxide dismutase (SOD), and glutathione (GSH) content of liver tissue were assayed by related kits. The activity of caspase-3 was detected by spectrophotometry. The expressions of cytochrome c, Bax, Bcl-2, c-Jun N-terminal kinase (JNK), and p-JNK were detected by western blot.RESULTS: The results showed that the levels of ALT, AST, IFN-γ, and TNF-α in AH (Venoplant®) groups were significantly lower than those in ConA-injured group, while the levels of TP, Alb, and A/G were significantly higher. The SOD and GSH levels were significantly increased, and the MDA level was decreased; liver histopathology was changed consistently with the serological indicators, AH (Venoplant®) treatment significantly reduced the pathological damage and cell apoptosis; while in AH (Venoplant®) group, the expressions of cytochrome c, caspase-3, Bax/Bcl-2 ratio, and p-JNK were significantly decreased.CONCLUSION: AH (Venoplant®) could significantly protect the ConA-induced acute liver injury in mice via inhibition of reactive oxygen species and JNK pathway.

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PMID: 

Br J Cancer. 2011 Sep 27 ;105(7):1069-75. Epub 2011 Sep 6. PMID: 21897393

Abstract Title: 

Incidence trends of vestibular schwannomas in Denmark, Finland, Norway and Sweden in 1987-2007.

Abstract: 

BACKGROUND: The reported incidence rates of vestibular schwannomas (VS) vary substantially, but it is unclear as to what extent the variation reflects differences in risk or recording practices. Our aim was to describe the incidence rates of VS in Denmark, Finland, Norway and Sweden between 1987 and 2007.METHODS: Comprehensive data were available from all registries only for the period from 1987 to 2007. An analysis of a longer time period (1965-2007) was conducted with the Norwegian and Swedish data.RESULTS: The average age-standardised incidence rates during 1987-2007 varied from 6.1 per 1,000,000 person-years (95% confidence interval (CI), 5.4-6.7) among Finnish men to 11.6 (95% CI, 10.4-12.7) in Danish men, and from 6.4 per 1,000,000 person-years (95% CI, 5.7-7.0) among Swedish women to 11.6 (95% CI, 10.5-12.8) among Danish women. An overall annual increase of 3.0% (95% CI 2.1-3.9) was observed when all countries and both sexes were combined, with considerable differences between countries. However, the practices of both reporting and coding VS cases varied markedly between countries and over time, which poses a challenge for interpretation of the results.CONCLUSION: The overall incidence of VS increased in all the four Nordic countries combined between 1987 and 2007, with marked differences between countries. However, the incidence rates more or less stabilised in the late 1990s, showing relatively constant incidence rates and even some decline after 2000.

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PMID: 

J Food Biochem. 2019 Mar ;43(3):e12758. Epub 2019 Jan 3. PMID: 31353546

Abstract Title: 

Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing.

Abstract: 

The effects of aqueous-ethanol extract of Horse chestnut (HCE) on MMP-1 and MMP-9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP-1 and MMP-9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA) levels in wound tissue were measured. Quercetin glucuronide in HCE was identified as main compound using a LC-MS/MS. The hydroxyproline level was significantly increased in the treated group versus control after the 3rd and 7th days (p 

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