PMID: 

Occup Environ Med. 2011 Sep ;68(9):631-40. Epub 2011 Jun 9. PMID: 21659469

Abstract Title: 

Risk of brain tumours in relation to estimated RF dose from mobile phones: results from five Interphone countries.

Abstract: 

OBJECTIVES: The objective of this study was to examine the associations of brain tumours with radio frequency (RF) fields from mobile phones.METHODS: Patients with brain tumour from the Australian, Canadian, French, Israeli and New Zealand components of the Interphone Study, whose tumours were localised by neuroradiologists, were analysed. Controls were matched on age, sex and region and allocated the 'tumour location' of their matched case. Analyses included 553 glioma and 676 meningioma cases and 1762 and 1911 controls, respectively. RF dose was estimated as total cumulative specific energy (TCSE; J/kg) absorbed at the tumour's estimated centre taking into account multiple RF exposure determinants.RESULTS: ORs with ever having been a regular mobile phone user were 0.93 (95% CI 0.73 to 1.18) for glioma and 0.80 (95% CI 0.66 to 0.96) for meningioma. ORs for glioma were below 1 in the first four quintiles of TCSE but above 1 in the highest quintile, 1.35 (95% CI 0.96 to 1.90). The OR increased with increasing TCSE 7+ years before diagnosis (p-trend 0.01; OR 1.91, 95% CI 1.05 to 3.47 in the highest quintile). A complementary analysis in which 44 glioma and 135 meningioma cases in the most exposed area of the brain were compared with gliomas and meningiomas located elsewhere in the brain showed increased ORs for tumours in the most exposed part of the brain in those with 10+ years of mobile phone use (OR 2.80, 95% CI 1.13 to 6.94 for glioma). Patterns for meningioma were similar, but ORs were lower, many below 1.0.CONCLUSIONS: There were suggestions of an increased risk of glioma in long-term mobile phone users with high RF exposure and of similar, but apparently much smaller, increases in meningioma risk. The uncertainty of these results requires that they be replicated before a causal interpretation can be made.

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PMID: 

Endocr Metab Immune Disord Drug Targets. 2019 Apr 15. Epub 2019 Apr 15. PMID: 30987578

Abstract Title: 

Lepidine B&E as new target inhibitors from Lepidium sativum seeds against four enzymes of the pathogen Candida albicans: in vitro and in silico studies.

Abstract: 

BACKGROUND AND OBJECTIVE: The present paper aims to study the inhibition of Candida albicans growth as candidiasis treatment, using seeds of Lepidium sativum as source.METHODS: In vitro assays were carried out on the antifungal activity of three kinds of extracts from L. sativum seeds against four strains of C. albicans, then testing the same phytochemicals on the inhibition of Lipase (LCR). A new in silico study was achieved using molecular docking, with Autodock vina program, to find binding affinity of two important and major lepidine alkaloids (lepidine E and B) towards the four enzymes secreted by C. albicans as target drugs, responsible of vitality and virulence of this yeast cells: Lipase, Serine/threonine phosphatase, Phosphomannose isomerase and Sterol 14-alpha demethylase (CYP51).RESULTS: The results of the microdillution assay show that the hexanic and alkaloidal extracts have an antifungal activity with MICs: 2.25 mg/ml and 4.5mg/ml, respectively. However, Candida rugosa lipase assay gives a remarkable IC50 values for the hexanic extract (1.42± 0.04 mg/ml) followed by 1.7± 0.1 and 2.29 ± 0.09 mg/ml of ethyl acetate and alkaloidal extracts respectively. The molecular docking confirms a significant correlation between C. albicans growth and inhibition of crucial enzymes involved in the invasion mechanism and cellular metabolisms, for the first time there were an interesting and new positive results on binding modes of lepidine E and B on the four studied enzymes.CONCLUSION: Through this work, we propose Lepidine B&E as potent antifungal drugs.

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PMID: 

Wei Sheng Yan Jiu. 2000 Mar 30 ;29(2):102-3. PMID: 12725088

Abstract Title: 

[Effects of electromagnetic radiation from handsets of cellular telephone on neurobehavioral function].

Abstract: 

In order to study the effects of electromagnetic radiation from handsets of cellular telephone on neurobehavioral function, 81 staff with handsets of cellular telephone and 63 staff without handsets of cellular telephone from corporations were selected as the subjects. The subjects were investigated by questionnaire on their general health, lifestyle habit, suppress of spirit, handset using of cellular telephone, environmental exposure, morbidity, and the neurobehavioral core test battery(NCTB). The data was analyzed by chi-square, stepwise regression analysis and covariance statistics. The results showed that the average reaction time in user's group was longer than that in control group (P

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PMID: 

Evid Based Complement Alternat Med. 2019 ;2019:5947234. Epub 2019 Mar 7. PMID: 30984276

Abstract Title: 

Amelioration of CCl-Induced Hepatotoxicity in Rabbits bySeeds.

Abstract: 

The current study aimed to evaluate the probable protective effect ofseeds (LSS) against CClinduced hepatic injury in New-Zealand rabbits. Rabbits were randomly divided into two main groups; group-A (noninjured group, n=15) was divided to subgroups A1 (untreated control) and A2 and A3 which received 200&400 mg/kg bw of LSS, respectively, in their diet daily. Group-B (injured group, n=30) were subcutaneously injected with CCl(0.5 ml/kg bw) starting from day one of the experiment and were equally divided into 3 subgroups: B1 received normal standard diet and B2&B3 received 200&400 mg/kg bw of LSS, respectively, in their diet daily. Five rabbits of all subgroups were decapitated 5 and 10 weeks after experimental running. Biochemical analysis revealed significant decrease in serum levels of transaminases,-GT, ALP, total bilirubin, cholesterol, triglycerides associated with significant increase in the serum levels of T protein and albumin of 200 and 400 mg/kg bw of LSS protected rabbits for 5 and 10 weeks as compared with CCltreated rabbits. Oxidative stress and depressed antioxidant system of the liver tissues were markedly obvious in the CCltreated group. LSS administration reversed these results towards normalization. Histopathological examination of LSS protected rabbits (200 mg/kg bw of LSS for 10 weeks) showed improvement of the histoarchitectural changes of the liver induced by CClto the normal aspect, showing regenerating hepatocytes with no steatosis, discrete chronic venous congestion, and discrete inflammatory infiltrate. The current findings provide new evidence that LSS could reverse the hepatotoxic effects of CCland repair the liver functions.

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PMID: 

Int Arch Occup Environ Health. 2001 Aug ;74(6):443-9. PMID: 11563608

Abstract Title: 

Non-Hodgkin's lymphomas and occupation in Sweden.

Abstract: 

OBJECTIVES: To investigate whether there is a risk excess of non-Hodgkin's lymphoma among Swedish workers associated with particular occupations.METHODS: The base population was made up of Swedish men (1,779,646) and women (1,101,669) who were gainfully employed at the time of the 1970 census, had also been present in the 1960 census and were still alive and older than 24 years as of 1 January, 1971. They were followed up for 19 years until the end of 1989. Age-period standardised incidence ratios were computed in a dataset linking cancer diagnoses from the Swedish national cancer register to occupational and demographic data obtained in the census of 1970. Log-linear Poisson models were fitted, allowing for geographical area. Risk estimators per occupation were also computed for workers reporting the same occupation in 1960 and 1970, a more specifically exposed group.RESULTS: There were 7,610 non-Hodgkin's lymphomas reported in the study cohort, 5,391 cases in men and 2,219 in women. A relative risk of over 1.20 and statistically significant was observed in men among accountants and auditors, secretaries and typists, auctionists, non-specified rail and road transport workers, telecommunications traffic officers, telegraph and radio operators, photographic-laboratory workers and other production and related work. The risk excess was confirmed in men with the same occupation in both censuses. In women, only three occupations achieved statistical significance: metal platers and coaters, truck and conveyor operators and store and warehouse workers.CONCLUSIONS: The risk excess observed in telecommunication and transport workers could be explained by electromagnetic radiation exposure. We did not find a risk excess in agricultural occupations, that has been largely documented by other study groups.

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PMID: 

Dose Response. 2019 Apr-Jun;17(2):1559325819850425. Epub 2019 May 20. PMID: 31191184

Abstract Title: 

Susceptibility Assessment of Methicillin-ResistantStrains toExtract.

Abstract: 

Many plant-derived compounds have been used to treat microbial infections.a common cause of many organ infections, has generated increasing concern due to its resistance to antibacterial drugs. This work was carried out to explore the susceptibility of 6 strains (LN872136, LN872137, LN871238, LN871239, LN872140, and LN871241) of methicillin-resistantto aqueous extract ofseeds in vitro. Various concentrations (5-20 mg/mL) were used to evaluate the effect of the extract on bacteria growth via the assessment of the microbial biomass and the inhibition zone (IZ). The results showed that the plant extract at 15 or 20 mg/mL, significantly decreased the the biomass ofstrains after 24 or 48 hours exposure period.(LN871241) showed the largest IZ at 20 mg/mL and documented by scanning electron microscope. The current work may suggest thatseed extract can be candidate as a promising antimicrobial agent to treat infection with methicillin-resistant.

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PMID: 

Int J Radiat Biol. 2002 Nov ;78(11):1029-36. PMID: 12456290

Abstract Title: 

Melatonin metabolite excretion among cellular telephone users.

Abstract: 

PURPOSE: The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77).MATERIALS AND METHODS: Participants collected urine samples and recorded cellular telephone use over 3 consecutive workdays. Personal 60-Hz magnetic field (MF) and ambient light exposures were characterized on the same days using EMDEX II meters. A repeated measures analysis was used to assess the effects of cellular telephone use, alone and combined with MF exposures, after adjustment for age, participation month and light exposure.RESULTS: No change in 6-OHMS excretion was observed among those with daily cellular telephone use>25 min in Study 1 (5 worker-days). Study 2 workers with>25 min cellular telephone use per day (13 worker-days) had lower creatinine-adjusted mean nocturnal 6-OHMS concentrations (p=0.05) and overnight 6-OHMS excretion (p=0.03) compared with those without cellular telephone use. There was also a linear trend of decreasing mean nocturnal 6-OHMS/creatinine concentrations (p=0.02) and overnight 6-OHMS excretion (p=0.08) across categories of increasing cellular telephone use. A combined effect of cellular telephone use and occupational 60-Hz MF exposure in reducing 6-OHMS excretion was also observed in Study 2.CONCLUSIONS: Exposure-related reductions in 6-OHMS excretion were observed in Study 2, where daily cellular telephone use of>25 min was more prevalent. Prolonged use of cellular telephones may lead to reduced melatonin production, and elevated 60-Hz MF exposures may potentiate the effect.

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PMID: 

Int J Occup Med Environ Health. 2012 Mar ;25(1):31-40. Epub 2012 Jan 5. PMID: 22219055

Abstract Title: 

Subjective complaints of people living near mobile phone base stations in Poland.

Abstract: 

OBJECTIVES: The aim of our study was to assess the health conditions and subjective symptoms of the inhabitants living in the base stations vicinity and to analyse the relationship between the complaints and level of exposure to electromagnetic fields (EMF).MATERIALS AND METHODS: Our study was performed in housing estates located in five regions ofŁódź. The electric field measurements were performed in the buildings located closest to the azimuth of the antennas. Respondents were selected by trained interviewers using an uniform procedure. The number of the households to be examined was set at a minimum of 420. The questionnaire contained:demographic data, occupational and environmental exposure to EMF, health condition, subjective complaints. Results were adjusted for confounders (age, gender, EMF at the workplace and EMF emitted by household equipment) using multiple regression model.RESULTS: 181 men and 319 women from 500 households were examined. Electric field above 0.8 V/m was recorded in 12% of flats. There was no significant correlation between electric field strength and the distance of examined flats from the base stations. To make possible comparison with relevant literature, we analysed also the frequency of the reported symptoms vs. the distance. Headache was declared by 57% people, most frequently (36.4%) living 100-150 m away from the base station compared to people living at longer distances (p = 0.013). 24.4% subjects, mostly living at a distance above 150 m, declared impaired memory. Difference was statistically significant in comparison with people living at other distances (p = 0.004).CONCLUSIONS: The explanation why we did not find any correlation between the electric field strength and frequency of subjective symptoms but found a correlation between subjective symptoms and distance from base station needs further studies. Maybe new metrics of exposure assessment should be adopted for this purpose.

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PMID: 

J Food Biochem. 2019 Mar ;43(3):e12725. Epub 2018 Dec 7. PMID: 31353542

Abstract Title: 

The nutraceutical potential of Lepidium sativum L. seed flavonoid-rich extract in managing metabolic syndrome components.

Abstract: 

The present study aimed to investigate the phytochemical and pharmacological identities of a Lepidium sativum L. (LS) flavonoid-rich extract and its beneficial effects on metabolic, hormonal, and histological status. Chemical screening, as well as high-performance liquid chromatography with diode-array detection (HPLC-DAD) identified high concentrations of the main flavonoid compounds in LS crude extract such as flavonols (quercetin, kaempferol), flavones (luteolin, apigenin), and especially flavanones (naringin, naringenin). Examinations of the biochemical and histopathological aspects showed the curative effects carried by LS flavonoid-rich extracts on high-fat diet-fed Wistar rats. In this study, we propose that these molecules probably exerted the bioactivity observed in the treated group through improving insulin sensitivity, dyslipidemia, inflammation, and pancreasβ cell integrity. PRACTICAL APPLICATIONS: The LS seed is widely used in traditional medicine to treat hyperglycemia and inflammation. During the traditional mixture preparation, the thermal procedures could impair the bioactions of the most interesting group of LS phytoconstituants, flavonoids. Inthe present study, we propose an appropriate procedure to preserve those phytochemicals and suggest them as a substitute for the management of metabolic diseases. The dried LS extract showed an incredible set of effective flavonoids, which revealed hypoglycemic, hypolipidemic, anti-inflammatory, cytoprotective, and antidiabetic activities. Thus, LS flavonoids constitute a remarkable product to consider in pharmaceutical industry targeting diabetes and heart diseases. Due to their enormous antioxidant potential, the LS flavonoids could be also used in food engineering and cosmetic preparations.Their practical applications is however often limited by low solubility and stability in lipophilic media. Therefore, a modification of the flavonoid structure is possibly required.

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PMID: 

Med Pr. 2003 ;54(3):291-7. PMID: 14669585

Abstract Title: 

[Biological effects and health risks of electromagnetic fields at levels classified by INCRIP ans admissible among occupationally exposed workers: a study of the Nofer Institute of Occupational Medicine, Lodz].

Abstract: 

The aim of the study was to evaluate the effect of electromagnetic fields (EMF) on the workers' circulatory system, and to find out to what extent the EMF frequency, short-term (maximum values) and chronic (daily and lifetime doses) exposures influence the type of the observed disorders. The gathered data will help to evaluate whether hygiene standards that limit maximum admissible EMF values (e.g., ICNIRP standards) protect against adverse effects of exposure. The study covered workers employed in transformer and distribution stations, medium wave transmitting stations, radio-service and radio and TV multichannel broadcasting stations. In all the cases, exposure levels were considerably lower than those set as admissible according to the ICNIRP standards. Nevertheless changes in the circulatory system and a significant relationship between blood pressure and neurovegetative regulation disorders and exposure parameters were observed. The frequency of changes in the circulatory system was significantly dependent not only on the maximum EMF value, but also on its dose, which indicates that the hygiene standards for EMF cannot be limited only to short-term exposure maximum values, but they should be supplemented with dose-related standards.

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