PMID: 

J Dermatolog Treat. 2020 Apr 2:1-20. Epub 2020 Apr 2. PMID: 32237947

Abstract Title: 

Intralesional Injection of Vitamin D in Verruca Vulgaris Increases Cathelicidin (LL37) Expression; Therapeutic and Immunohistochemical Study.

Abstract: 

: Despite the promising results of intralesional vitamin D in verruca treatment; its precise mechanism of action is not fully understood.: To investigate immunohistochemical expression of cathelicidin (LL 37) before and after injection of vitamin D in verruca vulgaris and to clarify its possible role in pathogenesis of verruca.This study included 20 patients with multiple verrucae vulgaris. Vitamin D was intralesionally injected every 2 weeks for a maximum of 4 sessions or clearance of verrucae. Skin biopsies were taken from the patients before and at the end of the study and compared to skin samples from ten apparently healthy, age and sex matched individuals for histopathological and immunohistochemical assessment of LL37 expression.Eight (40%) verrucae showed complete response, seven (35%) showed partial response and five (25%) showed no response. Decreased epidermal thickness and reduced density of inflammatory cells in dermis were observed after injection. Significant increase in LL37 intensity of expression was observed after intralesional injection of vitamin D3 ( = 0.003) and in verrucae showing complete clinical response ( = 0.022).: Intralesional injection of vitamin D is effective and safe treatment for verruca vulgaris and causes increase in LL37 expression.

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PMID: 

Endocr Metab Immune Disord Drug Targets. 2020 Apr 2. Epub 2020 Apr 2. PMID: 32238143

Abstract Title: 

Vitamin D levels correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immuomodulatory Effect ofα, 25 Dihydroxyvitamin D3.

Abstract: 

BACKGROUND: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis.OBJECTIVE: The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunemodulatory effects of its active metabolite.METHODS: In this context, we evaluated the vitamin D status by electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and extracellular. Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunmodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-β and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determinated ex-vivo, while iNOS expression was assessed by immunofluorescence staining.RESULTS: Severe vitamin D deficiency was registered in Algerian MetS patients, the deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly,onα-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up regulated with α-25 (OH)2D3.CONCLUSION: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.

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PMID: 

Endocrine. 2020 Apr 1. Epub 2020 Apr 1. PMID: 32239452

Abstract Title: 

Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis.

Abstract: 

PURPOSE: The impact of vitamin D supplementation on thyroid function is not clear and the relationship between hypovitaminosis D and autoimmune thyroiditis (ATD) incidence and evolution is still a matter of debate. The aim of this study was to retrospectively evaluate the impact of vitamin D supplementation on thyroid function in subjects with and without ATD.METHODS: One hundred and ninety-eight euthyroid subjects, with diagnosis of"hypovitaminosis D"(

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PMID: 

Cell Immunol. 2020 Feb 28:104082. Epub 2020 Feb 28. PMID: 32241530

Abstract Title: 

Autophagy efficacy and vitamin D status: Population effects.

Abstract: 

Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D(1,25(OH)D)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are influenced by vitamin D status. Serum 25(OH)Dof healthy South Africans (Black individuals n = 10, White individuals n = 10) was quantified by LC-MS/MS. Primary monocytes-macrophages were supplemented in vitro with 1,25(OH)Dand stimulated with the lipoprotein PamCysSerLys. TLR2, VDR, hCAP18, Beclin1, LC3-IIB, cytokines and CYP24A1 mRNA were quantified by flow cytometry and RT-qPCR, respectively. Black individuals showed significantly lower overall cumulative LC3-IIB (P 

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We’re all in the midst of an epochal, civilization-level shift that is challenging us individually and collectively to our cores. 

In the disturbing video above, Dr. Mike Ryan, the head of the World Health Organization’s Emergencies Program, describes the W.H.O’s egregiously invasive recommendation that health authorities may come into people’s homes and take those suspected to be infected by COVID-19 to be quarantined, tested and presumably medicated against their will. 

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PMID: 

Pol Merkur Lekarski. 2001 Feb ;10(56):122-5. PMID: 11320579

Abstract Title: 

[Vitamin C in treatment of certain cardiovascular diseases].

Abstract: 

The human organism is incapable of producing vitamin C by biosynthesis. We are therefore totally dependent on the presence of this vitamin in our diet. Vitamin C is capable of essentially influencing the course of many metabolic processes, and it is therefore used in the treatment and prophylaxis of many diseases, including those that are a consequence of the activity of the so-called reactive forms of oxygen. The presence of vitamin C in the anti-oxidant protective system is believed to be very important, since it can react with the free radicals of oxygen and other oxidants, and"sweep"them away. Therefore, attention is more and more frequently focused on the possibility of using vitamin C in the treatment of those circulatory diseases that are believed to be associated with the action of free radicals. Routine administration of vitamin C should be therefore recommended in the treatment of patients with coronary arterial disease, treatment of patients after cardiac infarction or cerebral stroke, or in the treatment of arterial hypertension.

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PMID: 

Nutrients. 2018 Jul 27 ;10(8). Epub 2018 Jul 27. PMID: 30060468

Abstract Title: 

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.

Abstract: 

The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C's effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems. This review covers current knowledge about the role of vitamin C in cardiac surgery patients with focus on its influence on organ dysfunctions. The relationships between vitamin C and clinical health outcomes are reviewed with special emphasis on its application in cardiac surgery. Additionally, this review pragmatically discusses evidence on the administration of vitamin C in every day clinical practice, tackling the issues of safety, monitoring, dosage, and appropriate application strategy.

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PMID: 

J Am Heart Assoc. 2013 Nov 27 ;2(6):e000329. Epub 2013 Nov 27. PMID: 24284213

Abstract Title: 

Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies.

Abstract: 

BACKGROUND: Though vitamin C supplementation has shown no observed effects on stroke prevention in several clinical trials, uncertainty remains as to whether long-term, low-dose intake influences the development of stroke among general populations. Furthermore, the association between circulating vitamin C and the risk of stroke is also unclear. For further clarification of these issues, we conducted a meta-analysis of prospective studies.METHODS AND RESULTS: PubMed and EMBASE databases were searched, and the bibliographies of the retrieved articles were also reviewed to identify eligible studies. Summary relative risk (RRs) with corresponding 95% confidence intervals (CIs) were computed with a random-effects model. The summary RR for the high-versus-low categories was 0.81 (95% CI: 0.74 to 0.90) for dietary vitamin C intake (11 studies), and 0.62 (95% CI: 0.49 to 0.79) for circulating vitamin C (6 studies). The summary RR for each 100 mg/day increment in dietary vitamin C was 0.83 (95% CI: 0.75 to 0.93) (10 studies), and for each 20μmol/L increment in circulating vitamin C was 0.81 (95% CI: 0.75 to 0.88) (5 studies). Few studies reported results for vitamin C supplements (RR for high-versus-low intake=0.83, 95% CI: 0.62 to 1.10, 3 studies).CONCLUSIONS: This meta-analysis suggests significant inverse relationships between dietary vitamin C intake, circulating vitamin C, and risk of stroke.

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PMID: 

Curr Opin Clin Nutr Metab Care. 2015 Mar ;18(2):187-92. PMID: 25635597

Abstract Title: 

Vitamin D supplementation in the ICU patient.

Abstract: 

PURPOSE OF REVIEW: Recent findings suggest that vitamin D is a marker for outcomes in critical illness. The purpose of this review is to summarize current biological, observational and interventional evidence in the critically ill.RECENT FINDINGS: Both biological and observational studies support the role of vitamin D deficiency in adverse critical illness outcomes. Interventional trials of critically ill patients show that to improve vitamin D status, high-dose vitamin D3 is required. Critically ill patients have a relatively blunted response to vitamin D supplementation compared to the general outpatient population. Toxicity from high-dose vitamin D in trials in the critically ill has been limited to mild hypercalcemia. Recent evidence suggests that treatment of severely vitamin D-deficient critically ill patients with high-dose vitamin D early in the ICU course may improve mortality.SUMMARY: Vitamin D deficiency is a potentially modifiable marker for adverse outcomes in critical illness and critical illness survivors. Vitamin D supplementation is inexpensive and appears safe in critical illness trials. A well powered interventional trial is required to determine the definitive answer regarding the role of vitamin D supplementation in the improvement of critical care outcomes. Until such data are available, a cautious approach to correction of vitamin D status in the ICU is warranted.

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