PMID: 

Diabetes Metab Syndr. 2020 Jan 8 ;14(2):77-82. Epub 2020 Jan 8. PMID: 31991296

Abstract Title: 

The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptorγ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial.

Abstract: 

BACKGROUND & AIMS: Curcumin is a biologically active phytochemical ingredient found in turmeric and has antioxidant pharmacologic actions that may benefit patients with polycystic ovarian syndrome (PCOS). The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptorγ coactivator 1α (PGC1α) gene expression in PCOS patients.METHODS: Seventy-two patients with PCOS were recruited for this randomized, double-blinded, clinical trial. Thirty-six patients received curcumin, 1500 mg (three times per day), and 36 patients received placebo for 3 months. Gene expression of SIRT1, PGC1α and serum activity of glutathione peroxidase (Gpx) and superoxide dismutase (SOD) enzymes were evaluated at the beginning of trial and at 3-month follow-up.RESULTS: Sixty-seven patients with PCOS completed the trial. Curcumin supplementation significantly increased gene expression of PGC1α (p = 0.011) and activity of the Gpx enzyme (p = 0.045). Curcumin also non-significantly increased gene expression of SIRT1 and activity of the SOD enzyme.CONCLUSIONS: Curcumin seems to be an efficient reducer of oxidative stress related complications in patients with PCOS. Further studies on curcumin should strengthen our findings.

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PMID: 

Ecotoxicol Environ Saf. 2019 Apr 15 ;170:286-292. Epub 2018 Dec 7. PMID: 30530180

Abstract Title: 

Acute effect of ambient air pollution on hospitalization in patients with hypertension: A time-series study in Shijiazhuang, China.

Abstract: 

Although numerous studies have investigated the association between air pollution and hospitalization, few studies have focused on the health effect of air pollution on populations with hypertension. In this study, we conducted a time-series study to investigate the acute adverse effect of six criteria ambient air pollutants (fine particulate matter [PM], inhalable particulate matter [PM], nitrogen dioxide [NO], sulfur dioxide [SO], ozone [O], and carbon monoxide [CO]) on hospitalization of patients for hypertension in Shijiazhuang, China, from 2013 to 2016. An over-dispersed Poisson generalized addictive model adjusting for weather conditions, day of the week, and long-term and seasonal trends was used. In addition, we evaluated the effect of modification by season, sex, and age. A total of 650,550 hospitalization records were retrieved during the study period. A 10 μg/mincrease of PM(lag06), PM(lag06), NO(lag03), O(lag6), and CO (lag04) corresponded to 0.56% (95% confidence interval [CI]: 0.28-0.83%), 0.31% (95% CI: 0.12-0.50%), 1.18% (95% CI: 0.49-1.87%), 0.40% (95% CI: 0.09-0.71%), and 0.03% (95% CI: 0.01-0.05%) increments in hospitalization of patients for hypertension, respectively. We observed statistically significant associations with PM, PM, NO, O, and CO, while positive but insignificant associations with SO. The effects of PM, PM, NO, O, and CO were robust when adjusted for co-pollutants. We found stronger associations in the cool season than in the warm season. Moreover, there were non-significant differences in the associations between air pollution and sex or age group. This study suggests that patients with hypertension had an increased risk of hospital admission when exposed to air pollution.

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PMID: 

Environ Pollut. 2019 Mar ;246:183-189. Epub 2018 Dec 4. PMID: 30543944

Abstract Title: 

Impacts of air pollution on dry eye disease among residents in Hangzhou, China: A case-crossover study.

Abstract: 

The purpose of this study is to investigate the potential associations between air pollution and dry eye disease (DED). Data of outdoor air pollutants and meteorology as well as outpatient visits for DED were collected. A time-stratified case-crossover approach was used to analyze the associations between ambient air pollutants and outpatient visits for DED. Among the 5062 DED patients studied, 65.45% were female and 34.55% were male. In the single-pollutant model, significant associations were observed between an increase of 10 μg/min the concentrations of fine-particulate matter with a median aerometric diameter of less than 10 μm (PM), fine-particulate matter with a median aerometric diameter of less than 2.5 μm (PM), sulfur dioxide (SO), nitrogen dioxide (NO), and carbon monoxide (CO) and outpatient visits for DED. These results were consistent with those of the multipollutant model. The strongest associations between air pollutants and patient visits were observed during the cold season and in patients aged 21-40. The significant association between air pollutants (PM, PM, SO, NO, and CO) and DED outpatient visits indicates the importance of increased environmental protection.

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PMID: 

Sci Rep. 2018 11 27 ;8(1):17411. Epub 2018 Nov 27. PMID: 30479352

Abstract Title: 

Ambient Air Pollution Exposures and Newly Diagnosed Pulmonary Tuberculosis in Jinan, China: A Time Series Study.

Abstract: 

Few epidemiological studies have evaluated the effects of air pollution on the risk of pulmonary tuberculosis (TB). We investigated the associations of ambient air pollutants (particulate matter with aerodynamic diameter

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PMID: 

Ecotoxicol Environ Saf. 2019 Apr 30 ;171:206-210. Epub 2018 Dec 31. PMID: 30605850

Abstract Title: 

Air pollution exposures and blood pressure variation in type-2 diabetes mellitus patients: A retrospective cohort study in China.

Abstract: 

Air pollution exposure has been associated with hypertension, but limited studies have examined the associations in diabetic patients. We aimed to examine the associations of exposure to air pollution with blood pressure in diabetic patients. We identified patients who were previously diagnosed as type-2 diabetes mellitus from hospital records from January 2013 to May 2017. We used generalized linear models to estimate adverse effects of air pollution on systolic/diastolic blood pressure in diabetic patients. A total of 40,125 patients were enrolled in this study. An IQR increase in PM, PM, NO, SO, and Oexposure was associated with an increased risk of higher systolic blood pressure level (β = 0.628 for PM,β = 0.758 for PM,β = 0.766 for NO,β = 0.516 for SO,β = 0.482 for O, all P value 

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PMID: 

Environ Sci Pollut Res Int. 2019 Jun ;26(16):16261-16273. Epub 2019 Apr 11. PMID: 30977004

Abstract Title: 

Ambient air pollution and risk of type 2 diabetes in the Chinese.

Abstract: 

We performed a time series analysis to investigate the potential association between exposure to ambient air pollution and type 2 diabetes (T2D) incidence in the Chinese population. Monthly time series data between 2008 and 2015 on ambient air pollutants and incident T2D (N = 25,130) were obtained from the Environment Monitoring Center of Ningbo and the Chronic Disease Surveillance System of Ningbo. Relative risks (RRs) and 95% confidence intervals (95% CIs) of incident T2D per 10 μg/mincreases in ambient air pollutants were estimated from Poisson generalized additive models. Exposure to particulate matter

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To date, the U.S. has experienced unprecedented outbreaks of e-cigarette or vaping-associated lung injury and new research has linked synthetic vitamin E, used in vaping products, to lung injuries

PMID: 

Medicine (Baltimore). 2019 May ;98(19):e15553. PMID: 31083216

Abstract Title: 

Oseltamivir induced Stevens-Johnson syndrome/toxic epidermal necrolysis-case report.

Abstract: 

RATIONALE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are 2 rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions, and mucous membrane erosions. Drugs are highly suspected to be the causative agents. We report a case of SJS/TEN induced by oseltamivir, which is a very rare event.PATIENT CONCERNS: A 9-year-old girl with upper respiratory tract infections presented with generalized maculopapular rash the second day after taking oseltamivir.DIAGNOSIS: The diagnosis of SJS/TEN was made based on cytotoxic skin lesions and mucous membrane involvement.INTERVENTIONS: After discontinuing of the drug and combination therapy of corticosteroid and human immunoglobulin initiation, the lesions were improved. Human leukocyte antigen (HLA) gene sequencing was done.OUTCOMES: The girl was followed-up for 1 year. The skin and mucous membranes symptoms were relieved.LESSONS: We report this case to attract attention to the rare but serious side effect of this antiviral drug.

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PMID: 

Environ Int. 2019 09 ;130:104882. Epub 2019 Jun 12. PMID: 31202028

Abstract Title: 

Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study.

Abstract: 

BACKGROUND: Experimental studies have indicated that alterations in the gut microbiota might play a role in the pathway of diabetes induction resulting from particulate matter pollution with aerodynamic diameters 

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PMID: 

Environ Int. 2019 12 ;133(Pt A):105110. Epub 2019 Oct 11. PMID: 31610366

Abstract Title: 

Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder.

Abstract: 

BACKGROUND: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied.OBJECTIVE: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk.METHODS: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999-2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O), particulate matter 

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