PMID: 

Toxicol In Vitro. 2019 Dec ;61:104609. Epub 2019 Jul 24. PMID: 31351122

Abstract Title: 

Effects of radiofrequency electromagnetic field exposure on neuronal differentiation and mitochondrial function in SH-SY5Y cells.

Abstract: 

Exposure to radiofrequency electromagnetic fields (RF-EMF) has dramatically increased in the last decades with expanding use of mobile phones worldwide. The aim of this study was to evaluate effects of RF-EMF on neuronal differentiation and underlying signaling pathways involved in neuronal differentiation, neurodegeneration, and mitochondrial function. Differentiation of SH-SY5Y cells was performed using all-trans retinoic acid or staurosporine to obtain cholinergic and dopaminergic neurons. Exposure of SH-SY5Y cells at 935 MHz, 4 W/kg for 24 h did not alter the neuronal phenotypes quantitatively. Markers of the signaling pathways investigated, namely the mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases (Erk) 1 and 2 (p-Erk1/2) and protein kinase B (Akt), glycogen synthase kinase3 β (GSK3β) and Wnt/β-catenin were not significantly affected by RF-EMF compared to sham. RF-EMF-impaired mitochondrial respiration in cells under glucose deprivation, but glutathione levels and mitochondrial fission and fusion markers were not altered. These findings indicate that RF-EMF might lead to an impairment of mitochondrial function that is only manifest at maximal respiration and additional stressors such as glucose deprivation. Further research is needed to investigate the effects of RF-EMF on mitochondrial function in detail because mitochondrial impairment is closely related tothe pathogenesis of neurodegenerative diseases.

read more

PMID: 

J Chem Neuroanat. 2019 Dec ;102:101684. Epub 2019 Sep 22. PMID: 31553920

Abstract Title: 

Mobile phone induced cognitive and neurochemical consequences.

Abstract: 

With the rapid advances in technology, extensive use of mobile phones has increased the risk of health problems. This study was performed to find out the effect of mobile phone frequency on male Wistar rats. Animals were divided into two groups (n = 6 in each group). Group one was considered as control and group two (experimental group) was exposed to microwave radiation (2100 MHz) for 4 hours/day (5 days/week) for 3 months. Exposure of microwave radiation frequency showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. MWR exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration. Histopathological observations clearly depicted the neural degeneration. Thus, it can be concluded that MWR significantly affects the central nervous system and may lead to many severe illnesses. This study may reveal a platform to understand its toxic effect and can further be used for amendment in current guidelines of mobile radiation.

read more

PMID: 

Oncol Lett. 2019 Nov ;18(5):5383-5391. Epub 2019 Sep 20. PMID: 31612047

Abstract Title: 

Radiofrequency radiation from nearby mobile phone base stations-a case comparison of one low and one high exposure apartment.

Abstract: 

Radiofrequency (RF) radiation in the frequency range of 30-300 GHz has, since 2011, been classified as a 'possible' human carcinogen by Group 2B, International Agency for Research on Cancer (IARC) at WHO. This was based on a number of human epidemiology studies on increased risk for glioma and acoustic neuroma. Based on further human epidemiology studies and animal studies, the evidence on RF radiation carcinogenesis has increased since 2011. In previous measurement studies, it has been indicated that high environmental RF radiation levels are present in certain areas of Stockholm Sweden, including in one apartment. Field spatial distribution measurements were performed in the previously measured apartment in Stockholm, which exhibited high RF radiation from nearby base stations. Based on the RF broadband analyzer spot measurements, the maximum indoor E-field topped at 3 V min the bedroom at the 7th floor. The maximum outdoor exposure level of 6 V mwas encountered at the 8th floor balcony, located at the same elevation and only 6.16 m away from the base station antennas. For comparison, a measurement was made in a low exposure apartment in Stockholm. Here, the maximum indoor field 0.52 V mwas measured at the corner window, with direct line of sight to the neighboring house with mobile phone base station antennas. The maximum outdoor field of 0.75 V mwas measured at the balcony facing the same next-door building with mobile phone base station antennas. The minimum field of 0.10 V mwas registered on the apartment area closest to the center of the building, demonstrating the shielding effects of the indoor walls. Good mobile phone reception was achieved in both apartments. Therefore, installation of base stations to risky places cannot be justified using the good reception requirement argument.

read more

PMID: 

Environ Res. 2020 May ;184:109227. Epub 2020 Feb 13. PMID: 32199316

Abstract Title: 

A meta-analysis of in vitro exposures to weak radiofrequency radiation exposure from mobile phones (1990-2015).

Abstract: 

To function, mobile phone systems require transmitters that emit and receive radiofrequency signals over an extended geographical area exposing humans in all stages of development ranging from in-utero, early childhood, adolescents and adults. This study evaluates the question of the impact of radiofrequency radiation on living organisms in vitro studies. In this study, we abstract data from 300 peer-reviewed scientific publications (1990-2015) describing 1127 experimental observations in cell-based in vitro models. Our first analysis of these data found that out of 746 human cell experiments, 45.3% indicated cell changes, whereas 54.7% indicated no changes (p = 0.001). Realizing that there are profound distinctions between cell types in terms of age, rate of proliferation and apoptosis, and other characteristics and that RF signals can be characterized in terms of polarity, information content, frequency, Specific Absorption Rate (SAR) and power, we further refined our analysis to determine if there were some distinct properties of negative and positive findings associated with these specific characteristics. We further analyzed the data taking into account the cumulative effect (SAR× exposure time) to acquire the cumulative energy absorption of experiments due to radiofrequency exposure, which we believe, has not been fully considered previously. When the frequency of signals, length and type of exposure, and maturity, rate of growth (doubling time), apoptosis and other properties of individual cell types are considered, our results identify a number of potential non-thermal effects of radiofrequency fields that are restricted to a subset of specific faster-growing less differentiated cell types such as human spermatozoa (based on 19 reported experiments, p-value = 0.002) and human epithelial cells (based on 89 reported experiments, p-value

read more

PMID: 

Int J Environ Health Res. 2020 Mar 9:1-10. Epub 2020 Mar 9. PMID: 32149530

Abstract Title: 

Evidences of the (400 MHz – 3 GHz) radiofrequency electromagnetic field influence on brain tumor induction.

Abstract: 

Due to the massive increase in non-ionizing radiation emitting devices, the social concern about the possible malignancy to its exposure has increased the research interest. The International Commission on Non-Ionizing Radiation Protection (ICNIRP) included the radiofrequency electromagnetic field (RF-EMF) of mobile phones on the category 2B as 'possibly' carcinogenic to humans. Epidemiological studies noticed a causal association between the exposure to RF-EMF and the incidence of brain neoplasm in different populations, since this is the organ with the highest specific absorption rate. The fact that so many of the ipsilateral tumors found are statistically significant with RF-EMF exposure provides weight suggesting causality. In this way, the higher the exposure (ipsilateralcontralateral), the longer the cumulative exposure (hours of exposure) and the longer the latency (beyond 10 years); the greater the risk. In addition, considering together all of these parameters suggest a strong causality.

read more

PMID: 

J Biomed Phys Eng. 2019 Dec ;9(6):637-646. Epub 2019 Dec 1. PMID: 32039094

Abstract Title: 

Antibacterial Susceptibility Pattern of theandafter Exposure to Electromagnetic Waves Emitted from Mobile Phone Simulator.

Abstract: 

Background: The increasing use of telecommunication devices such as Wi-Fi modems and mobile phones in the recent years can change the cellular structure of microorganisms so the generation of electromagnetic waves has led to concern in the community whenever be exposed to these fields and may have harmful effects on human health.Material and Methods: In this experimental study, standard strains of bacteria were prepared on Mueller-Hinton agar for bacterial growth to obtain 0.5 McFarland turbidity (1.5× 10CFU) of bacteria. Antibiotic susceptibility test using the Kirby-Bauer disk diffusion method was done. Forand, antibiotics susceptibility test was conducted. The test group was exposed to electromagnetic waves emitted by mobile phone simulator with a frequency of 900 MHz and the control group were not exposed.Results: The results revealed that increasing duration of exposure to electromagnetic waves emitted by the mobile simulators with a frequency of 900 MHz especially after 24 h of exposure, can increase bacterial resistance in.Conclusion: Several factors can cause bacterial resistance against antibiotics. One of these factors is the electromagnetic waves emitted from mobile simulator with a frequency of 900 MHz, which can increase the permeability of the cell wall of bacteria.

read more

PMID: 

Am J Reprod Immunol. 2018 11 ;80(5):e13022. Epub 2018 Jul 27. PMID: 30051540

Abstract Title: 

Recurrent pregnancy loss and vitamin D: A review of the literature.

Abstract: 

Recurrent pregnancy loss (RPL) affects approximately 1%-2% of reproductive women. Auto- and cellular immune responses seem to be associated with RPL. Vitamin D (VD) has been shown to play a role in the modulation of the immune system. Effects of VD deficiency (VDD) in pregnancy have been associated with preeclampsia, gestational diabetes, fetal growth restriction, preterm labor, and sporadic spontaneous abortion (SA). We systematically reviewed articles that studied women with 2 or more SA and its association with VD. Eleven studies were included. Studies reported a high prevalence of VD insufficiency (VDI) or VDD in women with RPL and suggested that this could be associated with immunological dysregulation and consequently with RPL. Immunological benefits were reported in the peripheral blood of women with RPL after VD exposure. Thus, it is possible to speculate a beneficial role for VD supplementation in RPL. It seems that there are not differences in the vitamin D receptor (VDR) and CYP27B1 expression in endometrium of women with RPL but, in villous and decidual tissues, RPL women seem to have a decreased expression of VDR and, perhaps, a decreased expression of CYP27B1. Further randomized controlled studies are required to investigate the association between VDD or VDI and RPL.

read more

A study reveals that grape seed extract may be an effective natural therapy in lowering the blood pressure of men with prehypertension

Sipping on traditional kava tea may reduce tension while kava extract has been linked to increased cheerful mood, anxiety relief and more

PMID: 

Carbohydr Polym. 2016 Jun 25 ;144:382-9. Epub 2015 Dec 30. PMID: 27083830

Abstract Title: 

Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71.

Abstract: 

A novel heteropolysaccharide from Grifola frondosa mycelia was extracted and purified using DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance ((1)H NMR and (13)C NMR) spectroscopy were used to decipher the structure of the purified G. frondosa polysaccharide (GFP1). Chemical and spectral analysis revealed that GFP1, with an average molecular weight of 40.5kDa, possessed a 1,6-β-d-glucan backbone with a single 1,3-α-d-fucopyranosyl side-branching unit. Enterovirus 71 (EV71) is the causative pathogen of hand-foot-and-mouth disease. GFP1 was tested for its anti-EV71 activity in cultured cells, which showed that EV71 viral replication was blocked and viral VP1 protein expression and genomic RNA synthesis were suppressed. Moreover, GFP1 exhibited apoptotic and other activities by suppressing the EV71-induced caspase-3 cleavage and IκBα down regulation. Our results demonstrate that the novel G. frondosa polysaccharide has antiviral activity, which could be valuable as a potentially new anti-EV71 therapeutic compound.

read more