PMID: 

Clin Neurol Neurosurg. 2016 May ;144:126-8. Epub 2016 Mar 29. PMID: 27046292

Abstract Title: 

Recurrent optic neuritis and neuromyelitis optica-IgG following first and second human papillomavirus vaccinations.

Abstract: 

Human papillomavirus (HPV) vaccine is widely used to prevent cervical cancer caused by certain types of HPV in girls and young women. Demyelinating disorders within months following HPV innoculation have been reported, but the causal link between HPV vaccination and the onset of demyelinating disorders have not been certain. We report a case of neuromyelitis optica spectrum disorder (NMOSD) that was noteworthy because optic neuritis (ON) occurred in a very close temporal association with both the first and second HPV vaccinations, which might suggest an association between HPV vaccination and the development of NMO-IgG and recurrent ON. This emphasizes the necessity for continuing surveillance for adverse events after HPV vaccination.

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PMID: 

J AAPOS. 2009 Jun ;13(3):317-8. Epub 2009 Mar 14. PMID: 19285888

Abstract Title: 

Recurrent isolated sixth nerve palsy after consecutive annual influenza vaccinations in a child.

Abstract: 

Recurrent sixth nerve palsy in children in the absence of structural or other neurological abnormality is a rare occurrence. We report the case of recurrent isolated sixth (abducens) nerve palsy after consecutive annual influenza vaccinations in an otherwise-healthy 2-year-old boy. Investigations including magnetic resonance imaging of the brain and orbits after each episode failed to reveal any abnormality. The temporal relation to the immunizations supports but does not prove that the influenza immunization regimen was responsible.

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PMID: 

Clin Neurol Neurosurg. 2017 Sep ;160:116-118. Epub 2017 Jul 11. PMID: 28719871

Abstract Title: 

Optic neuritis in pregnancy after Tdap vaccination: Report of two cases.

Abstract: 

Two pregnant women developed one-eye blurring vision within three weeks after Tdap vaccination. Neurophtalmologic and MR examination confirmed an unilateral optic neuritis without evidence of underlying disease. Both patients had a full recovery, one after intravenous metilprednisolone. This is the first report of optic neuritis related with Tdap vaccination in pregnancy.

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PMID: 

Am J Ophthalmol. 1978 Oct ;86(4):544-7. PMID: 707601

Abstract Title: 

Optic neuritis complicating measles, mumps, and rubella vaccination.

Abstract: 

A 6-year-old boy developed bilateral optic neuritis with decreasing visual acuity 18 days after administration of live attenuated trivalent measles, mumps, and rubella vaccine. The patient was treated with oral corticosteroids. The optic neuritis resolved within several weeks and normal vision returned. An afferent pupillary defect persistent in the more severely involved eye for 14 months following vaccination.

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PMID: 

Am J Ophthalmol. 1997 Nov ;124(5):703-4. PMID: 9372734

Abstract Title: 

Optic neuritis after influenza vaccination.

Abstract: 

PURPOSE: To present evidence for a causal relation between optic neuritis and influenza vaccination.METHODS: Case report. In a 59-year-old woman with bilateral optic neuritis, neuro-ophthalmologic examination, magnetic resonance imaging, fluorescent treponemal antibody absorption test, antinuclear antibodies, and complete blood cell count and chemistry were performed.RESULTS: Our patient developed bilateral optic neuritis on two occasions, 1 year apart. No evidence of neuroretinitis, syphilis, or systemic lupus erythematosus was identified. Influenza vaccination was given 2 weeks before the onset of each episode.CONCLUSION: This case provides compelling clinical evidence that implicates influenza vaccination as a cause of optic neuritis.

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PMID: 

Mil Med. 2011 Jun ;176(6):699-701. PMID: 21702392

Abstract Title: 

Ocular vaccinia: a consequence of unrecognized contact transmission.

Abstract: 

A patient developed severe ocular vaccinia via autoinoculation after acquiring unrecognized contact-transmitted vaccinia from wrestling with vaccinated members of his unit. This case highlights both the need to reinforce infection-control measures among vaccinees and the need for providers to be familiar with the identification and treatment of cutaneous and ocular vaccinia infection.

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PMID: 

Klin Monbl Augenheilkd. 2001 Oct ;218(10):688-90. PMID: 11706386

Abstract Title: 

[Neuritis of the optic nerve after vaccinations against hepatitis A, hepatitis B and yellow fever].

Abstract: 

BACKGROUND: Vaccinations are preventive measures against serious infections. In relation to the number of vaccinations per year, the incidence of severe complications is extremely low.PATIENT: Two weeks after vaccinations against hepatitis A, hepatitis B and yellow fever in preparation for a trip to Africa a 21-year-old woman experienced an acute and irreversible loss of vision to 0,05 and nasal visual field defect in the left eye. Whereas vision acuity did not recover the scotoma disappeared within 6 weeks. Cerebrospinal fluid showed a lymphocytic pleocytosis. Oligoglonale bands were absent. Pathological parameters were not presented in the serum. The MRI showed a hyperintense thickening of optic nerve,as well as a hyperintense focus in right temporal side using the T(2)W-Sequence.CONCLUSION: Only few cases have been reported with neurological complications, such as encephalitis, following vaccinations each of the above mentioned. As no other causes for the inflammation were found, the optic nerve involvement must have been caused by the vaccination. Which of the three vaccinations caused encephalitis can not be classified.

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PMID: 

Am J Ophthalmol. 1996 Sep ;122(3):431-2. PMID: 8794720

Abstract Title: 

Multiple evanescent white dot syndrome after hepatitis B vaccine.

Abstract: 

PURPOSE: Hepatitis B vaccine has become an effective means of preventing complications of hepatitis B. However, it occasionally induces serious side effects. We report a case of multiple evanescent white dot syndrome (MEWDS) that occurred following hepatitis B vaccination.METHODS: A 23-year-old woman with a one-week history of progressive loss of vision in the left eye and bilateral photopsia was referred for examination. Her symptoms appeared 24 hours after a booster intramuscular injection of hepatitis B vaccine.RESULTS: Clinical examination, fluorescein angiography, and the course of events were typical of MEWDS.CONCLUSIONS: This case demonstrates the occasional occurrence of MEWDS after hepatitis B vaccine and suggests that hepatitis B virus immunization may be a risk factor for this retinal condition.

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PMID: 

Cornea. 2014 Sep ;33(9):988-9. PMID: 25062334

Abstract Title: 

Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient.

Abstract: 

PURPOSE: In this study, the case of a healthy pediatric patient who presented with herpes zoster (HZ) stromal keratitis after vaccination with live attenuated varicella vaccine (Varivax) and subsequent booster is described.METHOD: This is a retrospective case review.RESULTS: A 6-year-old girl with no medical history presented with HZ ophthalmicus and stromal keratitis. She had received the original Varivax vaccine at 1 year of age and a booster 1 year before presentation. Topical prednisolone acetate was started with subsequent improvement in inflammation and visual acuity. However, the patient was unable to be completely tapered off the steroids because of reactivation.CONCLUSIONS: HZ ophthalmicus with stromal keratitis is a rare but potentially damaging manifestation of the varicella zoster virus in the pediatric population. Long-term data regarding reactivation rates in the post-vaccination era are still limited. Close follow-up is needed to ensure resolution of the infiltrates, and reactivation may require long-term steroid therapy.

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PMID: 

Vaccine. 2004 Sep 3 ;22(25-26):3240-2. PMID: 15308345

Abstract Title: 

The first rapid onset optic neuritis after measles-rubella vaccination: case report.

Abstract: 

During the largest mass campaign for measles-rubella (MR) vaccination 33,000,000 people with an age range of 5-25 years were vaccinated in Iran. Some complications were encountered, including a rare case of optic neuritis. In the past 30 years of medical literature, five cases of optic neuritis have been reported but all of them were developed at least 8 days after vaccination. We are supposed to report the first case of rapid onset optic neuritis in which the complication came out just in few hours in a 16 years old boy.

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