Propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage.

PMID: 

J Vet Res. 2019 Sep ;63(3):423-431. Epub 2019 Sep 13. PMID: 31572824

Abstract Title: 

Protective Role of Propolis on Low and High Dose Furan-induced Hepatotoxicity and Oxidative Stress in Rats.

Abstract: 

Introduction: The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver.Material and Methods: Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups.Results: While MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p

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Propolis reduces the expression of autophagy-related proteins in chondrocytes under interleukin-1β stimulus.

PMID: 

Int J Mol Sci. 2019 Aug 1 ;20(15). Epub 2019 Aug 1. PMID: 31374866

Abstract Title: 

Propolis Reduces the Expression of Autophagy-Related Proteins in Chondrocytes under Interleukin-1β Stimulus.

Abstract: 

BACKGROUND: Osteoarthritis (OA) is a progressive and multifactorial disease that is associated with aging. A number of changes occur in aged cartilage, such as increased oxidative stress, decreased markers of healthy cartilage, and alterations in the autophagy pathway. Propolis extracts contain a mixture of polyphenols and it has been proved that they have high antioxidant capacity and could regulate the autophagic pathway. Our objective was to evaluate the effect of ethanolic extract of propolis (EEP) on chondrocytes that were stimulated with IL-1β.METHODS: Rabbit chondrocytes were isolated and stimulated with IL-1β and treated with EEP. We evaluated cell viability, nitric oxide production, healthy cartilage, and OA markers, and the expression of three proteins associated with the autophagy pathway LC3, ATG5, and AKT1.RESULTS: The EEP treatment reduces the expression of LC3, ATG5, and AKT1, reduces the production of nitric oxide, increases the expression of healthy markers, and reduces OA markers.CONCLUSIONS: These results suggest that treatment with EEP in chondrocytes that were stimulated with IL-1β has beneficial effects, such as a decrease in the expression of proteins associated with autophagy, MMP13, and production of nitric oxide, and also increased collagen II.

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Zataria multiflora has anti-amnesic effect and might improve memory deficit through anticholinesterase activity.

PMID: 

Avicenna J Phytomed. 2019 Nov-Dec;9(6):587-596. PMID: 31763217

Abstract Title: 

Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats.

Abstract: 

Objective: () has been proposed for memory enhancing in Persian traditional medicine; but to now, no study has been carried out in this field yet. The aim of this research was to study the plant effect on spatial memory in scopolamine-induced amnesia and investigateanticholinesterase effect of.Material and Methods: Aerial parts of the plant were extracted with methanol and standardized on the basis of rutin content. Male rats received three doses ofextract (100, 200 and 400 mg/kg, intraperitoneal (ip) for 7 days) and 30 min after the latest dose, scopolamine (1 mg/kg) was administered to animals. Learning capacity and spatial memory were studied using morris water maze (MWM) and passive avoidance test (PAT) methods. Anticholinesterase activity was studied using Ellman's method. Physostigmine (0.3 mg/kg) and piracetam (200 mg/kg) were used as positive controls.Results: All doses ofextract significantly decreased the distance and time spent to find the platform in MWM and increased the time latency in PAT test. In both MWM and PAT tests, the highest effect ofwas observed at 200 mg/kg which was in accordance with AChE inhibitory effect of the plant.Conclusion: Our findings indicate thathas anti-amnesic effect and might improve memory deficit through anticholinesterase activity.

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Propolis mouthwash was more efficient against the studied oral bacteria compared to chlorhexidine and listerine.

PMID: 

Front Dent. 2019 Jan-Feb;16(1):1-12. Epub 2019 Jan 20. PMID: 31608331

Abstract Title: 

Evaluation of Antibacterial Effect of Propolis and its Application in Mouthwash Production.

Abstract: 

Objectives: Our purpose was to determine the antibacterial properties of propolis and to evaluate its use as an antibacterial mouthwash with minimal complications.Materials and Methods: In this experimental laboratory study, an alcoholic propolis extract was prepared. The minimum inhibitory concentration (MIC) was calculated for four bacterial species including(),(),(), and() using agar dilution. According to the MIC, a propolis antibacterial mouthwash was produced and compared to water, chlorhexidine (CHX), and Listerine using laboratory rats for clinical examination. Salivary specimens of rats were collected at 12 hours, 1 week, and 2 weeks after using the mouthwash and examined by real-time polymerase chain reaction (RT-PCR). Data were analyzed using one-way analysis of variance (ANOVA) and repeated measures ANOVA (α=0.05).Results: The results of agar dilution by the number of colony-forming units showed the lowest MIC forand the highest for. Our RT-PCR findings indicated that water alone had no effect on the level of oral bacteria. Propolis mouthwash showed a significant difference with CHX and Listerine (P

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One third of physicians surveyed reported little or no confidence in pre-licensure vaccine studies.

PMID: 

Prev Med. 2013 Mar ;56(3-4):231-3. Epub 2013 Jan 15. PMID: 23333206

Abstract Title: 

Physicians' confidence in vaccine safety studies.

Abstract: 

OBJECTIVES: To ascertain, through two separate surveys among nationally representative networks of pediatricians (Peds) and family physicians (FM): 1) physicians' reported level of confidence in pre- and post-licensure vaccine safety studies; and 2) changes in reported level of confidence from 2007 to 2010/11.METHODS: Two surveys were conducted in August to October 2007 and in November 2010 to January 2011. The survey response rates were 81% (FM, 79%, Peds, 84%, p=0.07) for the 2007 survey (691/848) and 66% (FM, 61%, Peds, 70%, p=0.003) for the 2010/11 survey (532/811).RESULTS: One in three family physicians compared to one in ten pediatricians in both surveys reported little or no confidence in pre-licensure vaccine safety studies (p

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Propolis as an adjuvant in the healing of human diabetic foot wounds.

PMID: 

J Diabetes Res. 2019 ;2019:2507578. Epub 2019 Sep 12. PMID: 31612147

Abstract Title: 

Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca.

Abstract: 

Objective: Diabetic foot wounds are a relevant diabetes complication and a major health problem. It has been described that propolis has health benefits due to its anti-inflammatory, antioxidant, and support in the healing process. The current study assessed the effect of propolis as an adjuvant in the healing of human diabetic foot ulcers. This was evaluated in a randomized placebo-controlled study of subjects receiving care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca, Chile.Research Design and Methods: Randomized subjects received ambulatory healing treatment for diabetes foot wounds with propolis spray (3%), which was applied to cover the entire wound surface each time it was dressed from week 0 until cicatrization or 8 weeks as a maximum. Two serum samples were taken (day 0 and end of the study) for cytokine and oxidative stress analyses. Also, macro- and microscopy were analyzed in the process of wound healing.Results: The study comprised 31 subjects with type 2 diabetes in treatment for diabetic foot wounds in the Diagnostic and Treatment Centre from the Regional Hospital of Talca. Propolis promotes a reduction of the wound's area by an average of 4 cm, related to an increase in the connective tissue deposit compared to the control. Also, propolis increased the glutathione (GSH) and GSH/glutathione disulfide (GSSG) ratio (

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Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition.

PMID: 

Nat Prod Res. 2019 Nov 8:1-5. Epub 2019 Nov 8. PMID: 31698954

Abstract Title: 

Nigerian propolis: chemical composition, antioxidant activity andα-amylase and α-glucosidase inhibition.

Abstract: 

Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (,), one diarylpropane () and one prenylated flavanone () by the combination of chromatographic and spectroscopic techniques. Compounds,andwere found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibitedfree radical scavenging activity together with a promising antidiabetic effect againstα-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition ofgrowth. These results suggested that NP could be a good candidate in nutraceuticals and food products.

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Individuals receiving the HepB-CpG vaccine were twice as likely to experience a cardiovascular event than individuals receiving the Engerix-B vaccination.

PMID: 

MMWR Morb Mortal Wkly Rep. 2018 Apr 20 ;67(15):455-458. Epub 2018 Apr 20. PMID: 29672472

Abstract Title: 

Recommendations of the Advisory Committee on Immunization Practices for Use of a Hepatitis B Vaccine with a Novel Adjuvant.

Abstract: 

Hepatitis B (HepB) vaccination is the primary means of preventing infections and complications caused by hepatitis B virus (HBV). On February 21, 2018, the Advisory Committee on Immunization Practices (ACIP) recommended Heplisav-B (HepB-CpG), a yeast-derived vaccine prepared with a novel adjuvant, administered as a 2-dose series (0, 1 month) for use in persons aged≥18 years. The ACIP Hepatitis Vaccines Work Group conducted a systematic review of the evidence, including data from four randomized controlled trials assessing prevention of HBV infection and six randomized controlled trials assessing adverse events in adults. Seroprotective antibody to hepatitisB surface antigen (anti-HBs) levels were achieved in 90.0%-100.0% of subjects receiving HepB-CpG (Dynavax Technologies Corporation), compared with 70.5%-90.2% of subjects receiving Engerix-B (GlaxoSmithKline Biologicals). The benefits of protection with 2 doses administered over 1 month make HepB-CpG an important option for prevention of HBV.

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