PMID: 

Evid Based Complement Alternat Med. 2018 ;2018:5765047. Epub 2018 May 13. PMID: 29861773

Abstract Title: 

The Flavonoid Jaceosidin fromInduces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells.

Abstract: 

Jaceosidin is a single compound from the Japanese mugwort, which is used as a food and a traditional medicinal herb.extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC= 82.1 M in HSC-3 cells and 97.5 M in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle. In addition, jaceosidin increased cleavage of caspase-9 and caspase-3 in OSCC cells, although caspase-8 was not detected. In further experiments, jaceosidin downregulated Akt phosphorylation and ectopic activation of Akt blocked the antiproliferative effects of jaceosidin. Finally, we showed that jaceosidin has no effects on HaCaT normal epithelial cell viability, indicating selective chemotherapeutic potential of jaceosidin and that tumour-specific downregulation of Akt increases apoptosis and inhibits growth in OSCC cells.

read more

PMID: 

Mediators Inflamm. 2018 ;2018:6054069. Epub 2018 Mar 4. PMID: 29686531

Abstract Title: 

Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation.

Abstract: 

var.(Asteraceae,) is a well-known traditional medicinal herb used for treating various inflammatory disorders in Korea, Japan, China, and other Asian countries. In the present study, we investigated the effects ofextract (APO) on interleukin- (IL-) 1regulation and inflammasome activation in bone marrow-derived macrophages (BMDMs) and monosodium urate- (MSU-) induced peritonitis mouse model. The APO treatment to BMDMs primed with lipopolysaccharide (LPS) attenuated the NLRP3 and AIM2 inflammasome activation induced by danger signals, such as ATP, nigericin, silica crystals, and poly (dA:dT), respectively. Mechanistic study revealed that APO suppressed the ASC oligomerization and speck formation, which are required for inflammasome activation. APO treatment also reduced the ASC phosphorylation induced by the combination of LPS and a tyrosine phosphatase inhibitor.evaluation revealed that intraperitoneal administration of APO reduced IL-1levels, significantly (

read more

PMID: 

J Nutr Health Aging. 2016 ;20(5):533-9. PMID: 27102792

Abstract Title: 

Effects of Artemisia Princeps Supplementation on Bone Metabolism in Ovariectomized Rats.

Abstract: 

The aim of this study was to investigate the effects of Artemisia princeps (AP) extract on bone metabolism and its potential role in the prevention of osteoporosis in ovariectomized rats. Twenty-six female Sprague-Dawley rats were divided into five groups and treated as follows: sham-operated control group (SHAM); ovariectomized control group (OVX), ovariectomized group treated by gavage with 10 mg/kg/day alendronate (ALEN); ovariectomized group treated by gavage with 100 mg/kg/day Artemisia princeps (AP100); ovariectomized group treated by gavage with 300 mg/kg/day Artemisia princeps (AP300). Treatment of ovariectomized rats with AP extracts for 15 weeks prevented the reduction in bone thickness and trabecular bone mineral density caused by urinary Ca and Cr excretion, and also prevented the increase in bone turnover by maintaining the serum Ca/P ratio. As a result, the microarchitecture of the trabecular bone and cortical bone after ovariectomy was markedly improved by administration of AP extracts. In conclusion, AP prevented bone loss and osteoclast activity associated with high bone turnover in ovariectomized rats by controlling the serum Ca/P ratio and through anti-inflammatory and anti-oxidant properties. Our data implicate AP as a promising therapeutic option for the improvement of postmenopausal osteoporosis.

read more

PMID: 

J Med Food. 2019 Jun ;22(6):623-630. Epub 2019 Apr 25. PMID: 31021282

Abstract Title: 

Inhibits Growth, Biofilm Formation, and Virulence Factor Expression of.

Abstract: 

This study was designed to determine whether the ethanol extract ofcould inhibit the cariogenic activity of. The increase in acid production and biofilm formation bywere evaluated. The expression levels of virulence factor genes were determined by performing the real-time polymerase chain reaction (PCR). The bactericidal effect was tested by confocal laser scanning microscopy. Theextract was observed to inhibit the growth ofat concentrations>0.05 mg/mL ( 0.05 mg/mL. These experimental results were similar to that observed with the scanning electron microscopy. The results of the confocal microscopy revealed that theextract at high concentrations of 0.4-3.2 mg/mL showed a bactericidal effect in a concentration-dependent manner. According to the results of the real-time PCR analysis, it was observed that theextract inhibited the expression of virulence factor genes. These results suggest thatmay inhibit the cariogenic activity of, and may be useful as an anticariogenic agent.

read more

PMID: 

Biomed Res Int. 2015 ;2015:239519. Epub 2015 Jul 12. PMID: 26247012

Abstract Title: 

Artemisia princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria.

Abstract: 

In this study, we used ethanol extract of A. princeps and investigated its antibacterial effects against MRSA. Ethanol extract of A. princeps significantly inhibited MRSA growth and organic acid production during glucose metabolism at concentrations greater than 1 mg/mL (P 

read more

n/a

PMID: 

Food Sci Biotechnol. 2017 ;26(5):1457-1461. Epub 2017 Aug 28. PMID: 30263682

Abstract Title: 

Antiviral activities ofvar.essential oil and itsα-thujone against norovirus surrogates.

Abstract: 

var.is a well-known medicinal food, which has been used for the treatment of several diseases including bacterial infection. We examined the antiviral effects of the essential oil fromvar.and its compounds, borneol,α-thujone and camphor, against murine norovirus-1 (MNV-1) and feline calicivirus-F9 (FCV-F9). The time-of-addition plaque assays were used to determine the ability of essential oil to interfere with viral infection. The maximum activities, following the pretreatment of FCV-F9 and MNV-1, reached 48%inhibition on FCV-F9 and 64% inhibition on MNV-1 at 0.1 and 0.01% of the essential oil, respectively. Neither borneol nor camphor exhibited an antiviral activity, whereas α-thujone, a major compound of the essential oil, showed strong inhibition on FCV-F9 and MNV-1.

PMID: 

J Agric Food Chem. 2011 Nov 9 ;59(21):11367-84. Epub 2011 Oct 13. PMID: 21942448

Abstract Title: 

Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety.

Abstract: 

Artemisia dracunculus L. (tarragon) has a long history of use as a spice and remedy. Two well-described"cultivars"(Russian and French) are used widely and differ in ploidy level, morphology, and chemistry. Key biologically active secondary metabolites are essential oils (0.15-3.1%), coumarins (>1%), flavonoids, and phenolcarbonic acids. In vivo studies mainly in rodents, particularly from Russian sources, highlight potential anti-inflammatory, hepatoprotective, and antihyperglycemic effects. Despite concerns about the toxic effects of two of its main constituents, estragole (up to 82%) and methyleugenol (up to 39%), no acute toxicity or mutagenic activity has been reported at doses relevant for human consumption. Water extracts of A. dracunculus contain very low amounts of estragole and methyleugenol and, therefore, are considered to pose a very limited risk. Overall, a stronger focus on clinical studies and precise taxonomic and phytochemical definition of the source material will be essential for future research efforts.

read more

If you’re struggling with heartburn, constipation or other uncomfortable symptoms of gastroesophageal reflux disease (GERD), adding fiber to your diet, in the form of psyllium seed, may help

PMID: 

Nutr Neurosci. 2019 Oct 31:1-7. Epub 2019 Oct 31. PMID: 31665978

Abstract Title: 

Lmodulates the immune system in a multiple sclerosis mouse model.

Abstract: 

: Multiple sclerosis along with its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory and degenerative diseases of the central nervous system (CNS). Due to the unknown cause of the disease, the most common treatments of MS are targeted for the reduction of inflammation and the repairment of CNS tissue damage, especially myelin restoration. Due to the immune protective nature of herbs, it may be useful to evaluate the impact of herbs in the diet regimen of MS patients along with their immune-mediated effects. The purpose of this study was to investigate the effect of an aqueous extract of(Tarragon) on the treatment of EAE in C57BL/6 mice.In this experimental study, mice were divided into the following control, untreated EAE, andtreated EAE groups. EAE was induced by myelin oligodendrocyte glycoprotein (MOG35-55) in female C57BL/6 mice. The symptoms of the disease and the weight of the mice were recorded daily. On day 33 after EAE induction, the mice were sacrificed and the specimens were collected. Cell proliferation and cytokine release (TGF-β, IL-17 and IL-23) from mice cultured spleen cells was measured by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and ELISA respectively.Administration of the extract ofmitigated EAE symptoms (

read more

Cannabinoids and where it is legal, THC are trending this Thanksgiving. People all over the country are praising the benefits of CBD, so it is no surprise to see it on the dinner table Thursday.

Kiva Confections launched a cannabis-infused gravy available for a limited time this holiday season. The gravy comes as a powder containing 10mg of THC and is made with turkey stock, salt, onion, and garlic. To prepare, heat to a boil in a saucepan and stir with a whisk.

While cannabis is not legal everywhere or either medical or recreational use, there are plenty of ways to incorporate the benefits of cannabis with CBD.

Adding CBD to food is a fun, easy, and tasty way to take your daily dose, and share with family and friends. A survey conducted by the American Psychological Association revealed 38 percent of respondents experience increase stress during the holidays. Reduce stress this Thanksgiving by adding some CBD to your favorite holiday dishes. Here are a few ideas to get your CBD fix, relax, and have your turkey dinner.

Gravy and Sauces

If you can’t legally purchase the now Internet famous cannabis gravy, try adding CBD to yours. The oils and fats in gravy help CBD distribute evenly. CBD has a low boiling point, and gravies and sauces are not cooked on high heats making them the perfect dish to add CBD to.

Oils and Fats

CBD is best used when added to oils and fats. A popular way to cook with CBD is by making CBD butter. This quick and easy recipe can be used in a variety of dishes, including on your Thanksgiving turkey!

Beverages

Perhaps the easiest and most effective way to add CBD to food is with a beverage. Add CBD to your coffee after dinner with some pumpkin pie, or try this CBD-infused apple cider.

Baked Goods

What could be better than sweets and CBD? Check out our post Baking With CBD.