PMID: 

Evid Based Complement Alternat Med. 2018 ;2018:4341961. Epub 2018 Sep 19. PMID: 30327679

Abstract Title: 

Clinical Investigations of the Effect ofPeel Pellet on Obesity and Lipid Profile.

Abstract: 

Objectives: Several experimental studies have reported antiobesity and lipid-improving effects of. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact ofpeel pellet (CUPP) on obesity and lipid profile.Methods: For 118 patients with body mass index (BMI)>23 who tookpeel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed.Results: Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (

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PMID: 

Phytother Res. 2019 Sep 4. Epub 2019 Sep 4. PMID: 31486124

Abstract Title: 

Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo.

Abstract: 

The peel of Citrus unshiu Marcow. fruits (CU) has long been used as a traditional medicine that has therapeutic effects against pathogenic diseases, including asthma, vomiting, dyspepsia, blood circulation disorders, and various types of cancer. In this study, we investigated the effect of CU peel on metastatic melanoma, a highly aggressive skin cancer, in B16F10 melanoma cells, and in B16F10 cells inoculated-C57BL/6 mice. Our results show that ethanol extracts of CU (EECU) inhibited cell growth and increased the apoptotic cells in B16F10 cells. EECU also stimulated the induction of mitochondria-mediated intrinsic pathway, with reduced mitochondrial membrane potential and increased generation of intracellular reactive oxygen species. Furthermore, EECU suppressed the migration, invasion, and colony formation of B16F10 cells. In addition, the oral administration of EECU reduced serum lactate dehydrogenase activity without weight loss, hepatotoxicity, nor nephrotoxicity in B16F10 cell-inoculated mice. Moreover, EECU markedly suppressed lung hypertrophy, the number and expression of metastatic tumor nodules, and the expression of inflammatory tumor necrosis factor-alpha in lung tissue. In conclusion, our findings suggest that the inhibitory effect of EECU on the metastasis of melanoma indicates that it may be regarded as a potential therapeutic herbal drug for melanoma.

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PMID: 

Gut Pathog. 2018 ;10:16. Epub 2018 May 21. PMID: 29942354

Abstract Title: 

Key lime () inhibits the growth of triple drug resistant.

Abstract: 

Background: Eradication rate for() has decreased due to antibiotic resistance. Therefore, new strategies are needed to enhanceeradication, especially forwith high antibiotic resistance. The objective of this study was to evaluate anti-activities of constituents from key lime () and their possible inhibitory effects on urease activity ofMethods: strain ATCC 43526 and triple drug resistant (TDR)strains were used in this study. Urease activities ofstrains were measured by ammonia colorimetrical quantification using ELISA reader. Minimum inhibitory concentrations were determined by agar dilution method for antibiotics and by modified media dilution method for each constituent of().Results: extract decreased the number of colonies ofstrain ATCC 43526 and TDR. An increasing concentration ofextract attenuated urease activities ofstrain ATCC 43526 and TDRstrains. Among constituents of, citral and 4-hexen-3-one were found to be able to inhibit the growth ofstrain ATCC 43526 and TDRstrains. Furthermore, citral and 4-hexen-3-one inhibited urease activities ofstrain ATCC 43526 and TDRstrains in a dose-dependent manner.Conclusion: has antimicrobial effect on TDRstrains, suggesting thatmight have therapeutic potential to control antibiotic-resistantstrains that cause eradication failure using other antibiotics.

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PMID: 

Toxicol Rep. 2019 ;6:1091-1096. Epub 2019 Oct 14. PMID: 31687359

Abstract Title: 

Insecticidal activities ofessential oil against(Diptera: Culicidae).

Abstract: 

Background: In the recent time, global attention for the control of vectors has shifted from chemical insecticides to botanicals. In the present investigation, authors attempted to evaluate the efficacy of peel and leaf essential oil (EO) ofagainst.Results: The results revealed that both the oils possess more ovicidal activity (LC50 value of 5.26 ppm and 17.71 ppm for leaf and peel oil respectively at 72 h) than larvicidal activity. As larvicide, the essential oil from the peel ofshowed rapid effect with LC50 value of 128.81 ppm at 24 h which reduced to 106.77 ppm at 72 h while the leaf oil showed slow effect with LC50 value of 188.59 ppm, 107.37 ppm and 104.59 ppm at 24 h, 48 h and 72 h respectively. Again, the two essential oils did not show significant adulticidal activity. GC-MS analysis of boththe oils recorded presence of different compounds. As a major constituent compound of the leaf EO of, citral was tested for their ovicidal, larvicidal and adulticidal activities against. The result showed highest ovicidal activities (LC50 value of 4.84 ppm at 72 h) of citral followed by larvicidal (LC50 value of 87.02 ppm at 24 h) and adulticidal (LC50 value of 103.88 ppm at 24 h) activities.Conclusion: From this study, it can be concluded that the essential oil extracted from the leaf and peel ofand one of its major constituent compound citral can be included in the mosquito control programme of.

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PMID: 

Exp Gerontol. 2019 Nov 21:110786. Epub 2019 Nov 21. PMID: 31760082

Abstract Title: 

Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.

Abstract: 

Citrus is a group of popular fruit that includes oranges, lemons, limes and grapefruit but research of its peel on hyperlipidemia and its mechanism is rare reported. We examined the effect of pure total flavonoids from peel of Citrus (PTFC), an extract from the peel of Citrus Changshan-huyou which is a popular fruit in China, on hamsters with hyperlipoidemia induced by high-fat diet (HFD). We found that PTFC significantly reduced levels of serum cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-c) and improved levels of alanine transaminase (ALT), aspartate transaminase (AST) and Alkaline phosphatase (ALP) which associated with liver function in golden hamsters. Liver pathological results confirmed that the liver pathological section of golden hamster treated with PTFC was significantly improved compared with that of HFD group. The content of main cholesterol metabolic enzymes Cholesterol 7a-hydroxylase (CYP7A1) in liver was obviously recovered with PTFC treatment. Further studies shown that PTFC attenuated oxidative stress and free radical damage through superoxide dismutase (SOD) and malonyldialdehyde (MDA) tests and inflammatory injury by levels of Tumor Necrosis Factor-alpha (TNF-α) and interleukin-6 (IL-6) both in serum and hepatocyte of golden hamsters. Moreover, PTFC increased levels of RNA and protein expression of Peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ in liver, fat and skeletal muscle of hyperlipidemia golden hamster, significantly. Our results suggested that PTFC could play a hypolipidemic role through improvement of liver function by antioxidant and anti-inflammatory effects in hyperlipoidemia hamsters, its mechanism of action may through activating of PPARα and PPARγ.

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PMID: 

Prev Nutr Food Sci. 2019 Jun ;24(2):165-170. Epub 2019 Jun 30. PMID: 31328121

Abstract Title: 

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice.

Abstract: 

This study was performed to investigate the effect of aged black garlic ethyl acetate extract on scopolamine-induced cognitive impairment in mice. Aged garlic ethyl acetate extract (BG) was administrated at a dose of 25 or 50 mg/ kg in scopolamine-induced mice. Cognitive ability was evaluated using a Morris water maze test and a passive avoidance test. BGs (50 mg/kg) shortened the latency time that was increased by scopolamine and increased the platform crossing numbers that was significantly shortened by scopolamine after 5 days training in the Morris water maze test (

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PMID: 

J Int Soc Sports Nutr. 2015 ;12:40. Epub 2015 Oct 20. PMID: 26500463

Abstract Title: 

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.

Abstract: 

BACKGROUND: Zeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance.METHODS: In a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20-50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO2max and maximum performance wereevaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used.RESULTS: At baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p 

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PMID: 

Vaccine. 2015 Oct 5 ;33(41):5470-5474. Epub 2015 Aug 12. PMID: 26275478

Abstract Title: 

Management and outcome of Bacille Calmette-Guérin vaccine adverse reactions.

Abstract: 

BACKGROUND: Bacille Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines globally. Management of local BCG complications (injection site reactions and suppurative or non-suppurative lymphadenitis) varies between clinicians, and the optimal approach remains uncertain.AIM: To determine the clinical features, management and outcome of BCG complications at two large acute hospitals in London, United Kingdom.METHODS: All children presenting with complications of BCG vaccination between January 2008 and December 2013 were included in this observational study. Medical and electronic laboratory records were reviewed to determine clinical features, treatment and outcome.RESULTS: Sixty children presented with adverse reactions. Two-thirds (65%) presented with BCG lymphadenitis, one-third (30%) presented with injection site complications and two children (3%) presented with both injection site reaction and lymphadenitis; only one child (2%) had disseminated BCG disease. The majority (88%) of children with injection site reactions were managed conservatively; overall, 95% showed complete resolution within 6 months. Among children with lymphadenitis, 46% were managed conservatively, whilst 54% had anti-tuberculous therapy and/or a procedure (aspiration mostly, or surgery); complete resolution was seen in 59% of cases.CONCLUSIONS: Injection site reactions and non-suppurative lymphadenitis were generally managed conservatively, with good outcomes. There was more variation in management and outcome of suppurative lymphadenitis and the optimal approach remains uncertain.

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PMID: 

Ann Med. 2012 Jun ;44(4):404. Epub 2012 Apr 2. PMID: 22462602

Abstract Title: 

Human papillomavirus (HPV) vaccine policy and evidence-based medicine: are they at odds?

Abstract: 

[n/a]

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PMID: 

Infect Agent Cancer. 2013 Feb 1 ;8(1):6. Epub 2013 Feb 1. PMID: 23369430

Abstract Title: 

HPV vaccines and cancer prevention, science versus activism.

Abstract: 

The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in order to decrease the burden of cervical cancer. Careful analysis of HPV vaccine pre- and post-licensure data shows however that both of these premises are at odds with factual evidence and are largely derived from significant misinterpretation of available data.

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