PMID: 

Urol Nefrol (Mosk). 1989 Jul-Aug(4):12-6. PMID: 2800070

Abstract Title: 

[The use of ultraviolet-irradiated blood plasma in the treatment of pyelonephritis patients].

Abstract: 

Transfusions of ultraviolet-irradiated plasma were carried out in 30 pyelonephritis patients. Subjective sense of improvement, and relief of fever and intoxication were noted. The administration of ultraviolet-irradiated plasma had a controlling effect on lipid peroxidation and blood cortisol, aldosterone and insulin levels, contributed to the normalization of corticosteroid catabolism and stimulated energy metabolism and the antioxidant system. Products of plasma photochemical reaction to ultraviolet irradiation have immunomodulating effects. Treatment of pyelonephritis patients by ultraviolet-irradiated plasma transfusions has shortened the time of hospital stay.

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PMID: 

Khirurgiia (Mosk). 1997(4):44-7. PMID: 9297003

Abstract Title: 

[Ultraviolet autoblood irradiation in multimodal treatment of patients with diffuse peritonitis].

Abstract: 

The influence of ultraviolet autoblood irradiation (UV-ABI) on the treatment of patients with disseminated peritonitis has been studied. 109 UVABI procedures in 35 patients have been done. The general blood toxicity, plasma toxicity, sugar, creatinine and urea blood concentrations have decreased after the UVABI. Positive changes of immune system were detected: an increase of the T-lymphocytes number (60%), B-lymphocytes number (10%), and M.G.A immunoglobulins. The number of the circulating immunocomplexes has decreased by 36.5%. The UVABI is recommended for clinical use as an effective method of detoxication and immunocorrection.

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PMID: 

Vestn Khir Im I I Grek. 1990 Feb ;144(2):87-9. PMID: 2165696

Abstract Title: 

[Possibilities of using UV-irradiated blood in the prevention of serum hepatitis after blood transfusions during surgery].

Abstract: 

It was shown in 31 samples of donor blood containing HBsAg that independent of the irradiation dose HBsAg was not detected in 66.7% of the photomodified blood when using short wave UV radiation. Long-wave UV radiation provides disappearance of HBsAg in 50%. A conclusion is made on expedience of irradiation of the donor blood with ultraviolet rays before transfusion.

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PMID: 

Folia Haematol Int Mag Klin Morphol Blutforsch. 1988 ;115(5):669-87. PMID: 2465248

Abstract Title: 

[Effect of ultraviolet irradiation of autologous blood on cell volumes, cell adhesion and phagocytosis in normal probands and patients with multiple sclerosis].

Abstract: 

UVB induced changes of blood cell properties were investigated in 12 MS patients and in 10 healthy volunteers serving as normal controls. The mean cell volume (MCV) was determined by electronic sizing, the granulocyte and lymphocyte adherence was estimated in a capillary assay, and the phagocytic activity of granulocytes was measured in a test system based on the incorporation of opsonized baker's yeast (Saccharomyces cerevisiae). In MS patients the MCV of red cells and lymphocytes decreased rapidly within 6 UVB treatments. In contrast, the reduction of the granulocyte volume was delayed (between the 6th and 12th UVB). In the control group the mean value of the red cell and lymphocyte MCV remained rather unaffected. There was a slight rise of the granulocyte volume after the 6th UVB. The only significant change of adherence was an increase of granulocyte adherence in MS patients. Untreated patients had a significantly enhanced phagocytic activity in comparison to the control group. 6 UVB treatments included a significant reduction of the phagocytic activity in MS patients. However, subsequently the percentage of phagocytizing cells increased again, whereas the particle uptake per cell continued to decrease. In the control group only minor UVB induced changes of phagocytosis were observed. The in vitro UV irradiation caused an enhanced phagocytosis in the majority of cases in both controls and MS patients. In general, under the UVB treatment all parameters examined changed in the sense of a normalisation, in that the measured values reached a new level lying between the extreme pretreatment values accompanied by a reduced standard deviation. The effect of UVB was more pronounced in MS patients when compared with normal controls. This could result from an enhanced sensitivity to the influence of UVB of pathologically altered cells in MS patients. The monitoring of the MCV of red cells and lymphocytes as well as the repeated testing of granulocyte phagocytosis are recommended for supportion of therapy planning and follow-up of MS patients.

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PMID: 

Probl Tuberk. 1995(3):20-2. PMID: 7617626

Abstract Title: 

[Effectiveness of chemotherapy in combination with electrophoresis and ultraviolet irradiation of blood in newly diagnosed patients with destructive pulmonary tuberculosis].

Abstract: 

Efficacy of inpatient treatment was compared for 222 new-onset cases of destructive tuberculosis of the lungs. 86 patients received chemotherapy plus electrophoresis and UV blood irradiation (group 1), 136 patients received chemotherapy alone (group 2). Group 1 patients benefitted more; bacterial discharge ceased in 100%, destruction in 89% of patients within 3 months against 59% and 38%, respectively, in controls. Combined therapy prevents toxic allergic reactions and shortens hospital stay by 48 days.

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PMID: 

Vrach Delo. 1990 Jan(1):42-3. PMID: 2330708

Abstract Title: 

[Treatment via autotransfusion of UV-irradiated blood in patients with nonspecific lung diseases].

Abstract: 

An analysis of 53 patients with unspecific pulmonary diseases revealed changes of the main immunity values that were more pronounced in the older age groups. It was established that autotransfusion of UV-irradiated blood produced a normalizing effect on immunity values. The authors recommend this method in the clinical practice of unspecific pulmonary diseases, in particular, of the older age groups and intolerance of drug therapy.

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PMID: 

Vopr Kurortol Fizioter Lech Fiz Kult. 2001 Jul-Aug(4):13-7. PMID: 11561295

Abstract Title: 

[Ultraviolet irradiation of blood and peloid therapy (standard- and short-course) of patients with chronic bronchitis].

Abstract: 

Clinical symptoms, clinico-biochemical picture, immunograms and external respiration function were studied in 43 patients with chronic bronchitis undergoing UV blood radiation and peloid therapy. This treatment had a corrective effect on chronic bronchitis pathogenesis. Short courses of photon-peloid therapy showed the same effectiveness as routine ones at lower risk of side effects and higher cost efficiency.

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PMID: 

Zh Vopr Neirokhir Im N N Burdenko. 1990 May-Jun(3):11-4. PMID: 2168643

Abstract Title: 

[The ultraviolet irradiation of autologous blood and endolymphatic antibiotic therapy in treating pneumonia in patients with craniocerebral trauma].

Abstract: 

On the basis of analysis of 50 cases of craniocerebral injury complicated by pneumonia, the authors prove the efficacy of including ultraviolet irradiation of autologous blood and endolymphatic antibiotic therapy in the complex of therapeutic measures. The mortality and the period of in-hospital treatment of this group of patients reduced.

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PMID: 

Anesteziol Reanimatol. 1989 Jul-Aug(4):31-5. PMID: 2817495

Abstract Title: 

[Ultraviolet irradiation of the blood in the intensive treatment of acute exogenous poisoning].

Abstract: 

The application of ultraviolet blood irradiation with a MD73M"Izolda"apparatus (the optimal dose of UV irradiation was 100-150 J, the volume of irradiated blood, 180-6000 ml) to 221 patients with various intoxications demonstrated that the method considerably increased the efficiency of therapy both at the toxicogenic (in blood poison circulation) and somatogenic (following the body's detoxification) stages by showing less intoxication and diminished severity and probability of complication development. Stimulation of a cellular link of immunity is major in the mechanism of a therapeutic effect displayed by UV irradiation.

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PMID: 

Blood. 1986 Feb ;67(2):537-9. PMID: 3510683

Abstract Title: 

Ultraviolet irradiation of blood prevents transfusion-induced sensitization and marrow graft rejection in dogs.

Abstract: 

In a canine model using DLA-identical littermate pairs, we have shown that a regimen of three transfusions of donor blood given 24, 17, and 10 days before transplant uniformly leads to marrow graft rejection, presumably due to sensitization to minor (non-DLA) histocompatibility antigens. Untransfused dogs uniformly achieve sustained engraftment. In the present study, we investigated whether the exposure of blood to ultraviolet (UV) light (220-300 nm) prior to transfusion prevented sensitization of the recipient and allowed for successful marrow engraftment. Ten dogs were each given three pretransplant transfusions from the marrow donor. Each transfusion consisted of 50 mL of whole blood exposed in vitro to UV light for a total of 1.35 J/cm2. All ten dogs achieved engraftment. In contrast, all four dogs that had received sham-exposed transfusions rejected their grafts. In vitro studies revealed that although cell viability was not affected, leukocytes contained in UV-exposed blood were unable to function as stimulator cells in mixed leukocyte cultures or as accessory cells in mitogen-stimulated cultures. These data are consistent with the hypothesis that accessory cells are involved in transfusion-induced sensitization. We conclude that in vitro exposure of blood to UV light before transfusion prevents sensitization and allows for subsequent marrow engraftment.

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