PMID: 

Radiats Biol Radioecol. 1999 Mar-Jun;39(2-3):287-92. PMID: 10366956

Abstract Title: 

[Therapeutic effect of ultraviolet irradiation of autologous blood in early period of acute radiation sickness].

Abstract: 

In experiments with dogs the acute radiation sickness was caused by common relatively uniform 3.5 Gy dose gamma-irradiation. Reinfusion of UV-irradiated autologous blood induced undoubted curative effect, which manifested itself in increased mean life, reduced mortality, more full restoring of blood-formation.

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PMID: 

Vestn Khir Im I I Grek. 1987 Jan ;138(1):66-7. PMID: 3590539

Abstract Title: 

[Ultraviolet irradiation of the blood].

Abstract: 

An analysis of the experience with using the method of ultraviolet irradiation of blood in 85 patients with different surgical diseases has shown the method to be simple, available and highly clinically effective.

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PMID: 

Chin Med J (Engl). 2000 Nov ;113(11):991-5. PMID: 11776133

Abstract Title: 

Ultraviolet blood irradiation and oxygenation affects free radicals and antioxidase after rabbit spinal cord injury.

Abstract: 

OBJECTIVE: To investigate the effects of ultraviolet blood irradiation and oxygenation (UBIO) on free radicals and antioxidase after spinal cord injury in rabbits.METHODS: Totally, 186 rabbits were used and divided randomly into four experimental groups: control (n = 6), blood transfusion (n = 24), injured (n = 96) and treatment (n = 60) groups. The relative intensity of free radical (FR) signals, malondialdehyde (MDA) content, as well as the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were compared among the four groups at 6, 24, 48, and 72 hours and 6 days after injury.RESULTS: The relative intensity of FR signals in spinal cord tissue in the injured group increased at 48 hours and showed a striking difference compared with the control group; in the treatment group, it decreased and showed a striking difference compared with the injured group. MDA content in blood in the injured group increased and showed a striking difference at 6, 24 and 48 hours and showed a significant difference at 72 hours and 6 days after injury compared with the control group. In the treatment group, MDA content in blood decreased and showed a significant difference at 48 hours compared with the injured group. MDA content in spinal cord tissue increased in the injured group and showed a striking difference compared with the control group; in the treatment group, it decreased and showed a striking difference compared with the injured group at the corresponding times. The activity of SOD in blood and spinal cord tissue decreased in the injured group and showed a striking difference compared with the control group; in the treatment group, it increased and showed a striking difference compared with the injured group at the corresponding times. The changes in activity of GSH-PX in blood and spinal cord tissue were similar to that in SOD. No significant difference was observed between the blood transfusion and control groups.CONCLUSION: UBIO can ease free radical damages and elevate the activity of antioxidases after spinal cord injury in rabbits.

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PMID: 

Vestn Khir Im I I Grek. 1992 Jul-Aug;149(7-8):84-8. PMID: 1341376

Abstract Title: 

[The efficacy of the ultraviolet irradiation of the blood in the combined treatment of erysipelatous inflammation].

Abstract: 

An experience with treatment of 1527 patients with different forms of erysipelas is analyzed. Under study were clinical data, nonspecific resistance parameters, peripheral and central hemodynamics and viscosity of blood. Ultraviolet irradiation of blood is an effective method of pathogenetical treatment of erysipelas which results in rapid arrest of local and general symptoms of the disease. The number of complications and recurrences was reduced.

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PMID: 

Expert Rev Anti Infect Ther. 2012 Feb ;10(2):185-95. PMID: 22339192

Abstract Title: 

Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections?

Abstract: 

This review discusses the potential of ultraviolet C (UVC) irradiation as an alternative approach to current methods used to treat localized infections. It has been reported that multidrug-resistant microorganisms are equally sensitive to UVC irradiation as their wild-type counterparts. With appropriate doses, UVC may selectively inactivate microorganisms while preserving viability of mammalian cells and, moreover, is reported to promote wound healing. UVC is also found in animal studies to be less damaging to tissue than UVB. Even though UVC may produce DNA damage in mammalian cells, it can be rapidly repaired by DNA repair enzymes. If UVC irradiation is repeated excessively, resistance of microorganisms to UVC inactivation may develop. In summary, UVC should be investigated as an alternative approach to current methods used to treat localized infections, especially those caused by multidrug-resistant microorganisms. UVC should be used in a manner such that the side effects would be minimized and resistance of microorganisms to UVC would be avoided.

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PMID: 

Int J Infect Dis. 2015 Aug ;37:58-63. Epub 2015 Jun 17. PMID: 26092299

Abstract Title: 

The treatment of infectious disease with a medical device: results of a clinical trial of ultraviolet blood irradiation (UVBI) in patients with hepatitis C infection.

Abstract: 

OBJECTIVES: Prior to the advent of therapies with sustained virological response rates of 94%, this study was conducted for the US Food and Drug Administration (FDA) to assess the safety and efficacy of ultraviolet blood irradiation (UVBI) for the treatment of hepatitis C virus (HCV) infection.METHODS: Nine patients received 15 UVBI treatments over the course of 22 weeks with the AVIcure Hemo-modulator, which was modified from the original Knott Hemo-irradiator. The patients' viral loads and liver function tests were obtained periodically during the study and analyzed during the course of the trial.RESULTS: At the end of the study, the overall mean reduction in HCV viral load was 21.5% (p = 0.023); on day 140, direct bilirubin declined by 41.1% (p=0.0059), aspartate aminotransferase declined by 15.2% (p=0.0069), and alanine aminotransferase declined by 19.3% (p=0.0031). The nadir of the mean and median viral load occurred on day 259, and it corresponded to a mean viral load reduction of 44.9% (p=0.0048). During the course of the study, three patients had a greater than 0.5 log reduction in viral load (patient 1, 0.56 log reduction on day 259; patient 4, 0.69 log reduction at the end of the study; patient 11, 0.91 log reduction on day 259). Two patients showed marked improvement in their concurrent psoriasis at the conclusion of the trial.CONCLUSIONS: In this study, UVBI was safe and had a beneficial effect in the treatment of HCV. This device should be studied for use in psoriasis and in infectious diseases that have few treatment options. This article describes a prospective, controlled, phase II clinical trial submitted to the FDA of this device used for the treatment of HCV infection (Investigational Device Exemption (IDE) #G030242).

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Despite decades of development, genetically engineered Golden Rice hasn’t yet been approved for commercial sale

Benign thyroid nodules are one of the most common endocrine disorders and may respond to a combination of natural extracts including spirulina, curcumin and Boswellia

You’re likely already aware that global plastic pollution has reached an all-time high, but did you know you’re eating it, too?

PMID: 

Int Immunopharmacol. 2018 Sep ;62:251-260. Epub 2018 Jul 20. PMID: 30032050

Abstract Title: 

1, 25-dihydroxyvitamin Ddownregulates cytotoxic effector response in pulmonary tuberculosis.

Abstract: 

1,25-dihydroxyvitaminD[1,25(OH)D] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)Don cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (PBMCs) from 45 healthy controls (HCs) and 45 pulmonary tuberculosis (PTB) patients were cultured with Mtb in the absence or presence of 1,25(OH)Dfor 72 h. The percentage of perforin, granulysin, and granzyme-B positive cells were estimated by flow cytometry. 1,25(OH)Dsignificantly decreased the percentage of cytolytic molecules in total, CD4+, CD8+ and CD56+ cells in HCs and PTB patients (p 

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